Controlled release of protein from gelatin/chitosan hydrogel containing platelet-rich fibrin encapsulated in chitosan nanoparticles for accelerated wound healing in an animal model

Mirjalili, Fatemeh; Mahmoodi, Mahboobeh

doi:10.1016/j.ijbiomac.2022.11.117

Cited by 16 publications

(8 citation statements)

References 105 publications

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“…Due to its internal cross-linked sparseness, the water retention of the CO gel was poor, maintaining only 19.3% of the original amount after 36 h (Figure d). However, compared with the commercial alginate dressing (Biatain Alginate), the hydrogel groups exhibited satisfactory WVTR behavior (Figure e), which is in line with the natural skin tissue permeability range …”

Section: Resultssupporting

confidence: 63%

Self-Healing Conductive Hydrogels with Dynamic Dual Network Structure Accelerate Infected Wound Healing via Photothermal Antimicrobial and Regulating Inflammatory Response

Liu,

Wang,

Cheng

et al. 2024

ACS Appl. Mater. Interfaces

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Wound infections are an escalating clinical challenge with continuous inflammatory response and the threat of drugresistant bacteria. Herein, a series of self-healing conductive hydrogels were designed based on carboxymethyl chitosan/ oxidized sodium alginate/polymerized gallic acid/Fe 3+ (CMC/ OSA/pGA/Fe 3+ , COGFe) for promoting infected wound healing. The Schiff base and catechol−Fe 3+ chelation in the dynamical dual network structure of the hydrogels endowed dressings with good toughness, conductivity, adhesion, and self-healing properties, thus flexibly adapting to the deformation of skin wounds. In terms of ultraviolet (UV) resistance and scavenging of reactive oxygen species (ROS), the hydrogels significantly reduced oxidative stress at the wound site. Additionally, the hydrogels with photothermal therapy (PTT) achieved a 95% bactericidal rate in 5 min of near-infrared (NIR) light radiation by disrupting the bacterial cell membrane structure through elevated temperature. Meanwhile, the inherent antimicrobial properties of GA could reduce healthy tissue damage caused by excessive heat. The composite hydrogels could effectively promote the proliferation and migration of fibroblasts and possess good biocompatibility and hemostatic effect. In full-thickness infected wound repair experiments in rats, the COGFe5 hydrogel combined with NIR effectively killed bacteria, modulated macrophage polarization (M1 to M2 phenotype) to improve the immune microenvironment of the wound, and shortened the repair time by accelerating the expression of collagen deposition (TGF-β) and vascular factors (CD31). This combined therapy might provide a prospective strategy for infectious wound treatment.

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Section: Resultssupporting

confidence: 63%

Self-Healing Conductive Hydrogels with Dynamic Dual Network Structure Accelerate Infected Wound Healing via Photothermal Antimicrobial and Regulating Inflammatory Response

Liu,

Wang,

Cheng

et al. 2024

ACS Appl. Mater. Interfaces

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“…From developing a simple treatment to formulating a vaccine, chemically modified polysaccharides have the potential to revolutionize the landscape of drug delivery in coming time. " swelling behaviour Rapid wound closure Sustained protein release from wounds [132] Chitosan/hyaluronan Methotrexate, 5 amino levulinic acid Nanogels # Proinflammatory cytokines: TNF-α, IL-17A in imiquimodinduced psoriatic mice " Transdermal drug penetration&retention in vivo&in vitro " Apoptosis in lipopolysaccharide-irritated HaCaT cells Effective against psoriasis [133] Thiolated chitosan Paclitaxel Nanoparticle 98.27 % drug encapsulation " cytotoxicity against breast carcinoma cell lines( NIH 3T3,T47D No cytotoxicity against colon cancer cell lines (HT29, Caco2) [134] Pectin with hydroxy propyl β cyclodextrin Honokiol Self assembled Nanoparticle " Enhanced cytotoxicity in HepG2 cells " Apoptosis Enhanced drug release [135] Pectin chitosan conjugate Cetuximab Nanoparticle Effective against colorectal cancer [136] (NA: Not available) ChemistrySelect…”

Section: Discussionmentioning

confidence: 99%

Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

et al. 2023

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The pressing need for the development of diversified and non‐toxic biomaterials in recent decades has led to the emergence of novel and valuable structural modifications in polysaccharides to broaden their spectrum of applications. Polysaccharides are macromolecules with multifaceted diverse structures and exhibit wide range of pharmacological and biological activities. Naturally occurring polysaccharides such as starch, chitosan, alginate, acetalated dextran and pectin could potentially negate major concerns associated with the selection of suitable polysaccharides without compromising their unique bioactive nature. Chemical modification of polysaccharides offers distinctive benefits such as improved biocompatibility, stability, solubility, and functionality making them more valuable for a variety of biomedical applications such as drug delivery, gene delivery, cell culture technology and tissue engineering. The present review is a compendium of relevant chemically modified polysaccharides and discusses their role in diverse fields of pharmacy and medicine.

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“…The DPPH radical scavenging activity of SA/CS/Zn 2+ PDH was measured using the technique reported before [53]. The detailed steps of which can be found in the supplementary material.…”

Section: Antioxidant Activity Of Sa/cs/zn 2+ Pdh In Vitromentioning

confidence: 99%

Double Network Physical Crosslinked Hydrogel for Healing Skin Wounds: New Formulation Based on Polysaccharides and Zn2+

Cui,

Yang,

et al. 2023

IJMS

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Developing convenient, efficient, and natural wound dressings remain the foremost strategy for treating skin wounds. Thus, we innovatively combined the semi-dissolved acidified sol-gel conversion method with the internal gelation method to fabricate SA (sodium alginate)/CS (chitosan)/Zn2+ physically cross-linked double network hydrogel and named it SA/CS/Zn2+ PDH. The characterization results demonstrated that increased Zn2+ content led to hydrogels with improved physical and chemical properties, such as rheology, water retention, and swelling capacity. Moreover, the hydrogels exhibited favorable antibacterial properties and biocompatibility. Notably, the establishment of an in vitro pro-healing wound model further confirmed that the hydrogel had a superior ability to repair wounds and promote skin regeneration. In future, as a natural biomaterial with antimicrobial properties, it has the potential to promote wound healing.

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Controlled release of protein from gelatin/chitosan hydrogel containing platelet-rich fibrin encapsulated in chitosan nanoparticles for accelerated wound healing in an animal model

Cited by 16 publications

References 105 publications

Self-Healing Conductive Hydrogels with Dynamic Dual Network Structure Accelerate Infected Wound Healing via Photothermal Antimicrobial and Regulating Inflammatory Response

Self-Healing Conductive Hydrogels with Dynamic Dual Network Structure Accelerate Infected Wound Healing via Photothermal Antimicrobial and Regulating Inflammatory Response

Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

Double Network Physical Crosslinked Hydrogel for Healing Skin Wounds: New Formulation Based on Polysaccharides and Zn2+

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