Controlled release of protein from magnetite–chitosan nanoparticles exposed to an alternating magnetic field

Abstract

In this research, the controlled release of proteins from magnetite (Fe3O4)–chitosan (CS) nanoparticles exposed to an alternating magnetic field is reported. Fe3O4–CS nanoparticles were synthesized with sodium tripolyphosphate (TPP) molecules as a crosslinking reagent. Bovine serum albumin (BSA) was used as a model protein, and its controlled release studied through the variation of the frequency of an alternating magnetic field. The results show the successful coating of CS and BSA on the Fe3O4 nanoparticles with an average diameter of 50 nm. Intermolecular interactions of TPP with CS and BSA were confirmed by Fourier transform infrared spectroscopy. The application of low‐frequency alternating magnetic fields to such magnetic CS nanoparticles enhanced the protein release properties, in which the external magnetic fields could switch on the unloading of these nanoparticles. We concluded that enhanced BSA release from nanoparticles exposed to an alternating magnetic field is a promising method for achieving both the targeted delivery and controlled release of proteins. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43335.

Design of Immobilized Enzyme Biocatalysts: Drawbacks and Opportunities

“…This high level of concern about this substance is caused by its high magnetic saturation, low cytotoxicity, good biocompatibility and stability in a variety of physiological conditions. [183][184][185] Magnetite has recently been commonly combined with natural polymers or with other materials such as graphene, graphene oxide or carbon nanotubes as well as poly (3-thiophene acetic acid), L-carnosine and alginic acid to produce functional hybrid nanomaterials or nanocomposites 183,[186][187][188][189][190] as shown in Figure 1 (H).…”

Biocompatible superparamagnetic nanoparticles with ibuprofen as potential drug carriers

“…Furthermore, NPs covering with biocompatible biopolymers such as chitosan, a cationic biopolymer at lower pHs, has attracted particular attention since it presents low toxicity, mucoadhesive properties, a flexible structure, and hydroxyl and amino groups with strongly affinity with water [19,[30][31][32]. Chitosan (CS), has been extensively researched in recent years as a primary material in the formation of carriers for therapeutic proteins and as non-viral gene-carrying vehicles [33][34][35], being therefore used in several pharmaceutical applications [33].…”

Synthesis of thermoresponsive copolymer/silica‐coated magnetite nanoparticle composite and its application for heavy metal ion recovery

“…Recently, the synthesis of polymer/magnetite nanoparticle composites has been reported 18–25 . Bhaumik et al reported that polypyrrole was immobilized on MNPs for the removal of fluoride from aqueous solution 21 .…”

“…16,17 Recently, the synthesis of polymer/magnetite nanoparticle composites has been reported. [18][19][20][21][22][23][24][25] Bhaumik et al reported that polypyrrole was immobilized on MNPs for the removal of fluoride from aqueous solution. 21 Cabrera et al reported the synthesis of magnetic biocatalysts by immobilizing polyaniline on MNPs.…”