Controlled Release of Phenytoin from Nanostructured TiO<SUB>2</SUB> Reservoirs

Influence of Water/Alkoxide Ratio in the Synthesis of Nanosized Sol−Gel Titania on the Release of Phenytoin

“…The primary particles almost immediately aggregate, forming the primary aggregates of about 50 nm size. 13 The primary aggregates almost do not have porosity as one can see from TEM micrographs discussed below. Thus, slitlike micropores of 2.5 nm are most likely the result of aggregation of the primary aggregates with the formation of the secondary aggregates.…”

“…10,[13][14][15][16] Since the majority of these factors may be controlled by the parameters of the sol-gel synthesis, the drug release kinetics, therefore, may be tuned by tailoring the processing parameters during the sol-gel reaction. [17][18][19][20][21][22][23] One of the parameters to control is the water/alkoxide ratio r w .…”

Effect of Thermal Treatment of Sol‐Gel Titania Reservoirs on Release Kinetics of Phenytoin

“…Indeed, it was shown that the hydrothermal treatment of titania during the sol-gel synthesis resulted in different particle sizes of titania, which was reflected later in different release rates of phenytoin. 10 However, in that case phenytoin was incorporated by adsorption after the temperature treatment, which is less effective than its incorporation during the synthesis. The main problem of calcination of the matrix with an encapsulated drug is the thermal lability of many drugs.…”

Glass fibers templated preparation of TiO2 microtubes assembled from nano/micro hierarchical TiO2 crystals

“…Recently the hierarchical structures based on the assembly of nanoscale building blocks absorb our attention. For instance, hierarchically structured nanowires or nanorods made of TiO 2 [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28], ZnO [29][30][31][32], SnO 2 [33], ZnO/TiO 2 [34], SnO 2 /Fe 2 O 3 [35], and V 2 O 5 /TiO 2 [36] have been prepared via various routes. No doubt that abundant voids deriving from the stacking or parallel growth of the building blocks increase the specific surface area to a large extent.…”