Controlled release of moxifloxacin from intraocular lenses modified by Ar plasma-assisted grafting with AMPS or SBMA: An in vitro study

Pimenta, Andreia; Vieira, Ana Paula; Colaço, R.; Saramago, Benilde; Gil, M.H.; Coimbra, Patrícia; Alves, Patrícia; Bozukova, Dimitriya; Correia, Tiago Ruivo; Correia, Ilídio J.; Guiomar, A. Jorge; Serro, Ana Paula

doi:10.1016/j.colsurfb.2017.04.060

Cited by 22 publications

(10 citation statements)

References 31 publications

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“…Previous studies introduced medium renovation in the in vitro release tests from IOLs to simulate the aqueous humor renovation [ 12 ]. More complex systems, such as microfluidic chambers [ 13 ], have also been suggested to simulate the renovation rate. The use of mathematical and numerical simulations has gained interest as a fast and accurate solution for the estimation of the drug release from ocular implants or intraocular injections in vivo [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Asymmetry in Drug Permeability through the Cornea

et al. 2021

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The permeability through the cornea determines the ability of a drug or any topically applied compound to cross the tissue and reach the intraocular area. Most of the permeability values found in the literature are obtained considering topical drug formulations, and therefore, refer to the drug permeability inward the eye. However, due to the asymmetry of the corneal tissue, outward drug permeability constitutes a more meaningful parameter when dealing with intraocular drug-delivery systems (i.e., drug-loaded intraocular lenses, intraocular implants or injections). Herein, the permeability coefficients of two commonly administered anti-inflammatory drugs (i.e., bromfenac sodium and dexamethasone sodium) were determined ex vivo using Franz diffusion cells and porcine corneas in both inward and outward configurations. A significantly higher drug accumulation in the cornea was detected in the outward direction, which is consistent with the different characteristics of the corneal layers. Coherently, a higher permeability coefficient was obtained for bromfenac sodium in the outward direction, but no differences were detected for dexamethasone sodium in the two directions. Drug accumulation in the cornea can prolong the therapeutic effect of intraocular drug-release systems.

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Section: Introductionmentioning

confidence: 99%

Asymmetry in Drug Permeability through the Cornea

et al. 2021

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“…LbL coatings were tested as barriers to the release of diclofenac, moxifloxacin, ketorolac, or chlorhexidine [70], but only diclofenac evidenced a slower release after the modification. Plasma-assisted grafting with HEMA [71] or 2-acrylamido-2-methylpropane sulfonic acid [66] in the presence of moxifloxacin resulted in a 15-day drug release above the therapeutic concentration, which is comparable to the common duration of the prophylactic treatment that is required after surgery. The incorporation of drug reservoirs in the implanted IOL was first suggested between 2006 and 2008 [27,117].…”

Section: Cataractmentioning

confidence: 93%

“…Several methods have been suggested to produce coatings on drug-eluting biomedical devices (e.g., layer-by-layer deposition, spray coating, dip coating, plasma-assisted grafting) with the purpose of implementing drug-eluting reservoirs [64][65][66][67][68][69][70][71][72][73]. Besides, these coatings may be used in order to increase the hydrophilicity of the device surface [74] and, also, as diffusion barriers to drug release [75][76][77].…”

Section: Coatingmentioning

confidence: 99%

Therapeutic Ophthalmic Lenses: A Review

2020

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An increasing incidence of eye diseases has been registered in the last decades in developed countries due to the ageing of population, changes in lifestyle, environmental factors, and the presence of concomitant medical conditions. The increase of public awareness on ocular conditions leads to an early diagnosis and treatment, as well as an increased demand for more effective and minimally invasive solutions for the treatment of both the anterior and posterior segments of the eye. Despite being the most common route of ophthalmic drug administration, eye drops are associated with compliance issues, drug wastage by lacrimation, and low bioavailability due to the ocular barriers. In order to overcome these problems, the design of drug-eluting ophthalmic lenses constitutes a non-invasive and patient-friendly approach for the sustained drug delivery to the eye. Several examples of therapeutic contact lenses and intraocular lenses have been developed, by means of different strategies of drug loading, leading to promising results. This review aims to report the recent advances in the development of therapeutic ophthalmic lenses for the treatment and/or prophylaxis of eye pathologies (i.e., glaucoma, cataract, corneal diseases, or posterior segment diseases) and it gives an overview of the future perspectives and challenges in the field.

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“…Finally, it is expected that a significant part of the population will have intraocular lenses (IOLs) implanted in the near future based on aging and extended life expectancies. So far, only few attempts have been made to use IOLs as drug delivery agents to prevent postoperative infection (Bouledjouidja et al, 2016;Mehta et al, 2015;Pimenta et al, 2017;Vieira et al, 2017) and inflammation (Bouledjouidja et al, 2016) or posterior capsule opacification, the most frequent complication of cataract surgery (Huang et al, 2013;Wertheimer et al, 2017). As far as we know, this has not resulted in commercial applications.…”

Section: Other Devicesmentioning

confidence: 99%

“…Furthermore, pharmacokinetics can be altered due to eye rotations (Bonfiglio et al, 2015;Stocchino et al, 2007), ocular diseases (Guo et al, 2017;Ho et al, 2014;Li et al, 2016), ocular surgery (Cantor et al, 2007) and coating and modification of IOL materials (Bouledjouidja et al, 2016;Huang et al, 2013;Mehta et al, 2015;Pimenta et al, 2017;Wertheimer et al, 2017).…”

Section: Challenges In Pharmacokineticsmentioning

confidence: 99%