Controlled release of mitomycin C from PHEMAH–Cu(II) cryogel membranes

Bakhshpour, Monireh; Yavuz, Handan; Deni̇zli̇, Adil

doi:10.1080/21691401.2018.1439840

Cited by 42 publications

(30 citation statements)

References 44 publications

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“…The imprinted polymer exhibited an IF of 2.7, with a maximum absorption capacity of 6.74 µmol·g −1 , the payload being released in a sustained manner within five days. A steeper release profile can be observed in the case of 5-FU [78] and MMC [81] imprinted DDS, nearly 80% of drug being released in just several hours, after reaching the plateau.…”

Section: Metal Ion-mediated Imprintingmentioning

confidence: 91%

“…The other listed metals are essential trace elements and they are generally required as cofactors for enzymatic reactions; in relatively large amounts however, they are harmful or toxic. To the best of our knowledge, the only metal ion used in DDS synthesis designed for cancer treatment is Cu(II) [78,80,81]. The Cu(II) release from the polymeric matrices as a result of the cleavage of coordination bonds could be however the cause of copper-related toxicity.…”

Section: Metal Ion-mediated Imprintingmentioning

confidence: 99%

“…In all reported studies, the imprinted polymers contained Cu(II) amounts much lower than the UL. In two studies, a polymerizable derivative of L-histidine, namely N-methacryloyl-(L)-histidine methyl ester (MAH), was used as functional monomer and metal-chelating ligand for the interaction with the template, represented by the 5-FU [78] or mitomycin C (MMC) [81] via Cu(II)-mediated coordination. Testing in various receiving media (pH 4.0-7.4) at 37 • C no copper leakage from the imprinted polymers has been detected by graphite furnace atomic absorption spectroscopy, suggesting that Cu(II) ions are strongly chelated to MAH ( Figure 4) in tridentate manner through the imidazole ring -N, amino -N, and deprotonated carboxylato -O atoms [78].…”

Section: Metal Ion-mediated Imprintingmentioning

confidence: 99%

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Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

2019

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Despite the considerable effort made in the past decades, multiple aspects of cancer management remain a challenge for the scientific community. The severe toxicity and poor bioavailability of conventional chemotherapeutics, and the multidrug resistance have turned the attention of researchers towards the quest of drug carriers engineered to offer an efficient, localized, temporized, and doze-controlled delivery of antitumor agents of proven clinical value. Molecular imprinting of chemotherapeutics is very appealing in the design of drug delivery systems since the specific and selective binding sites created within the polymeric matrix turn these complex structures into value-added carriers with tunable features, notably high loading capacity, and a good control of payload release. Our work aims to summarize the present state-of-the art of molecularly imprinted polymer-based drug delivery systems developed for anticancer therapy, with emphasis on the particularities of the chemotherapeutics' release and with a critical assessment of the current challenges and future perspectives of these unique drug carriers.Polymers 2019, 11, 2085 2 of 33 normal and abnormal cells, the severe toxicity and poor bioavailability of conventional drugs, and the multidrug resistance are issues that still need to be addressed by the scientific community.Polymers 2019, 11, x FOR PEER REVIEW 2 of 34 of both normal and abnormal cells, the severe toxicity and poor bioavailability of conventional drugs, and the multidrug resistance are issues that still need to be addressed by the scientific community.

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Section: Metal Ion-mediated Imprintingmentioning

confidence: 91%

Section: Metal Ion-mediated Imprintingmentioning

confidence: 99%

Section: Metal Ion-mediated Imprintingmentioning

confidence: 99%

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Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

2019

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“…In a study, 2-hydroxyethyl methacrylate (HEMA)-based cryogel membranes were prepared at different polymerization temperature to observe the effect on the pore size of membranes. They reported smaller pore size formation at lower cryogelation temperature [19].…”

Section: Factors Affecting Properties Of Cryogelsmentioning

confidence: 97%

“…Stimuli-responsive cryogels have attracted a great deal of attention of researchers because of their sensitive response to a variety of physical and chemical changes. The structure of cryogels has been defined as smart DDs to fulfill the desired drug release profiles [19].…”

Section: Controlled Drug Deliverymentioning

confidence: 99%

Biomedical Applications of Polymeric Cryogels

et al. 2019

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The application of interconnected supermacroporous cryogels as support matrices for the purification, separation and immobilization of whole cells and different biological macromolecules has been well reported in literature. Cryogels have advantages over traditional gel carriers in the field of biochromatography and related biomedical applications. These matrices nearly mimic the three-dimensional structure of native tissue extracellular matrix. In addition, mechanical, osmotic and chemical stability of cryogels make them attractive polymeric materials for the construction of scaffolds in tissue engineering applications and in vitro cell culture, separation materials for many different processes such as immobilization of biomolecules, capturing of target molecules, and controlled drug delivery. The low mass transfer resistance of cryogel matrices makes them useful in chromatographic applications with the immobilization of different affinity ligands to these materials. Cryogels have been introduced as gel matrices prepared using partially frozen monomer or polymer solutions at temperature below zero. These materials can be produced with different shapes and are of interest in the therapeutic area. This review highlights the recent advances in cryogelation technologies by emphasizing their biomedical applications to supply an overview of their rising stars day to day.

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