Controlled release of low-molecular weight, polymer-free corticosteroid coatings suppresses fibrotic encapsulation of implanted medical devices

Pakshir, Pardis; Younesi, Fereshteh; Wootton, Kelli-Anne; Battiston, Kyle G.; Whitton, Greg; Ilagan, Bernadette; Louka, Dimitra; Statham, Matthew; Mackey, Gillian; Daley, Adam B.; Parrag, Ian; Naimark, Wendy; Hinz, Boris

doi:10.1016/j.biomaterials.2022.121586

Cited by 12 publications

(11 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[25] The simple strategies, such as loading anti-inflammatory molecules and drugs can suppress FBR only for several days and weeks, that is definitely not qualified for many implant therapy because FBR is a long-term pathological process. [32] The "fingerprint" of an implant material is generated by its energy, chemistry, topography, roughness, and other properties.…”

Section: Physiochemical Property Forms the Protein "Fingerprint" Of I...mentioning

confidence: 99%

Decoding the “Fingerprint” of Implant Materials: Insights into the Foreign Body Reaction

Chen,

Luo,

Meng

et al. 2024

Small

View full text Add to dashboard Cite

Foreign body reaction (FBR) is a prevalent yet often overlooked pathological phenomenon, particularly within the field of biomedical implantation. The presence of FBR poses a heavy burden on both the medical and socioeconomic systems. This review seeks to elucidate the protein “fingerprint” of implant materials, which is generated by the physiochemical properties of the implant materials themselves. In this review, the activity of macrophages, the formation of foreign body giant cells (FBGCs), and the development of fibrosis capsules in the context of FBR are introduced. Additionally, the relationship between various implant materials and FBR is elucidated in detail, as is an overview of the existing approaches and technologies employed to alleviate FBR. Finally, the significance of implant components (metallic materials and non‐metallic materials), surface CHEMISTRY (charge and wettability), and physical characteristics (topography, roughness, and stiffness) in establishing the protein “fingerprint” of implant materials is also well documented. In conclusion, this review aims to emphasize the importance of FBR on implant materials and provides the current perspectives and approaches in developing implant materials with anti‐FBR properties.

show abstract

Section: Physiochemical Property Forms the Protein "Fingerprint" Of I...mentioning

confidence: 99%

Decoding the “Fingerprint” of Implant Materials: Insights into the Foreign Body Reaction

Chen,

Luo,

Meng

et al. 2024

Small

View full text Add to dashboard Cite

show abstract

“…Then, preventing the crosstalk, i.e., intercepting the messenger, early in the pathogenic process may be a useful strategy. For example, by pre-coating implants using potent anti-inflammatory drugs like steroids, fibrotic encapsulation could be prevented ( 122 , 123 ), although the use of corticoids may increase the risk of infections. In addition, this strategy can only be applied in situations when the time of initiation of the fibrotic cascade is known.…”

Section: Fibroblasts In Health and Diseasementioning

confidence: 99%

Melanocortin therapies to resolve fibroblast-mediated diseases

et al. 2023

View full text Add to dashboard Cite

Stromal cells have emerged as central drivers in multiple and diverse diseases, and consequently, as potential new cellular targets for the development of novel therapeutic strategies. In this review we revise the main roles of fibroblasts, not only as structural cells but also as players and regulators of immune responses. Important aspects like fibroblast heterogeneity, functional specialization and cellular plasticity are also discussed as well as the implications that these aspects may have in disease and in the design of novel therapeutics. An extensive revision of the actions of fibroblasts on different conditions uncovers the existence of numerous diseases in which this cell type plays a pathogenic role, either due to an exacerbation of their 'structural' side, or a dysregulation of their 'immune side'. In both cases, opportunities for the development of innovative therapeutic approaches exist. In this regard, here we revise the existing evidence pointing at the melanocortin pathway as a potential new strategy for the treatment and management of diseases mediated by aberrantly activated fibroblasts, including scleroderma or rheumatoid arthritis. This evidence derives from studies involving models of in vitro primary fibroblasts, in vivo models of disease as well as ongoing human clinical trials. Melanocortin drugs, which are pro-resolving mediators, have shown ability to reduce collagen deposition, activation of myofibroblasts, reduction of pro-inflammatory mediators and reduced scar formation. Here we also discuss existing challenges, both in approaching fibroblasts as therapeutic targets, and in the development of novel melanocortin drug candidates, that may help advance the field and deliver new medicines for the management of diseases with high medical needs.

show abstract

“…Dexamethasone (DEX) is a potent corticosteroid with safe systemic immunosuppressive effects [ 64 ]. DEX has a positive effect on the formation of fibrotic scars caused by implants, inhibiting the formation of collagen layers and the expression of fibrotic proteins and cellular markers on the implant surface [ 65 ]. However, systemic injections of DEX have well-documented side effects and are unsuitable for long-term systemic therapy [ 66 ].…”

Section: Drug Delivery Systemmentioning

confidence: 99%

Latest advances: Improving the anti-inflammatory and immunomodulatory properties of PEEK materials

Zhang

Zheng

et al. 2023

Materials Today Bio

View full text Add to dashboard Cite

Controlled release of low-molecular weight, polymer-free corticosteroid coatings suppresses fibrotic encapsulation of implanted medical devices

Cited by 12 publications

References 80 publications

Decoding the “Fingerprint” of Implant Materials: Insights into the Foreign Body Reaction

Decoding the “Fingerprint” of Implant Materials: Insights into the Foreign Body Reaction

Melanocortin therapies to resolve fibroblast-mediated diseases

Latest advances: Improving the anti-inflammatory and immunomodulatory properties of PEEK materials

Contact Info

Product

Resources

About