Controlled Release of Linalool Using Nanofibrous Membranes of Poly(lactic acid) Obtained by Electrospinning and Solution Blow Spinning: A Comparative Study

Abstract

The controlled-release of natural plant oils such as linalool is of interest in therapeutics, cosmetics, and antimicrobial and larvicidal products. The present study reports the release characteristics of linalool encapsulated at three concentrations (10, 15 and 20 wt.%) in poly(lactic acid) nanofibrous membranes produced by electrospinning and solution blow spinning (SBS) as well as the effect of linalool on fiber morphology and structural properties. PLA nanofibrous membranes were characterized by Scanning Electron Microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and contact angle measurements. The average diameters of the electrospun and solution blow spun nanofibers were similar, ranging from 176 to 240 nm. Linalool behaved as a plasticizer to PLA decreasing the glass transition temperature (Tg), melting point (Tm) and crystallization temperature (TC) of PLA. Curves of the release of linalool at 35 °C were non-linear, showing a clear biphasic pattern consistent with one or more Fickian release components. The time required to release 50% of linalool (t1/2) decreased with increasing linalool concentration. The range in t1/2 values for SBS nanofibers was higher (291-1645s) than the t1/2 values for electrospun fibers (76-575s).

Ions-modified nanoparticles affect functional remineralization and energy dissipation through the resin-dentin interface

“…These materials should ideally be able to provide calcium and phosphate ions for improving tooth remineralization, and nanosize will permit these materials to enter through tooth tissue porosities (Souza et al, 2015). This effect may also be facilitated by the ability of these NPs to inhibit dentin metalloproteinases (Osorio et al, 2014), enzymes implicated in dentinal carious process (Tjäderhane et al, 2015).…”

In vitro antimicrobial activity of solution blow spun poly(lactic acid)/polyvinylpyrrolidone nanofibers loaded with Copaiba (Copaifera sp.) oil

“…Fiber bundles are jettisoned from the nozzle tip in the SBS process towards a collector placed at a fixed working distance [31][32][33]. SBS has been successfully used in a series of controlled release studies including progesterone and linalool [34,35].…”

Cork ‐ a natural material for linalool controlled release

“…Since linalool is a well‐known natural insecticide and larvicide the research for materials to release linalool is not a novelty. Souza et al . reports the release characteristics of linalool encapsulated at three concentrations in Polylactic acid (PLA) nanofibrous membranes, as well as the effect of linalool on fiber morphology and structural properties.…”

“…reports the release characteristics of linalool encapsulated at three concentrations in Polylactic acid (PLA) nanofibrous membranes, as well as the effect of linalool on fiber morphology and structural properties. Further development of PLA membranes encapsulated with linalool oil was considered useful, in creating commercial markets for PLA/linalool composite materials with potential applications in controlled‐release devices …”

“…The means of effectively releasing volatile compounds often requires development of new delivery systems . In fact, there are several patents on essential oils release for indoor and closet use.…”