Controlled Release of Interleukin-2 from Chitosan Microspheres

Özbaş-Turan, Suna; Akbuğa, Jülide; Aral, Cenk

doi:10.1002/jps.10122

Cited by 71 publications

(39 citation statements)

References 19 publications

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“…An initial burst release was observed for both kinds of nanoparticles, which is a common phenomenon for many drug release systems. 23,24 However, the initial burst release is not severe compared with other systems. 12,25,26 The burst release is known as the result of quick release of the surface adsorbed drugs.…”

Section: Loading and Release Of Toothpaste Activesmentioning

confidence: 97%

Chitosan nanoparticles for loading of toothpaste actives and adhesion on tooth analogs

Liu

Chen

Mao

et al. 2007

J of Applied Polymer Sci

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Delivery and sustained release of toothpaste actives is an important but unexplored area. In this work, chitosan nanoparticles were prepared by a water-inoil emulsion/glutaraldehyde crosslinking method. The typical number average diameter of chitosan and toothpaste active (cetylpyridiniumchloride and NaF) nanoparticles was within the range of 100-500 nm. The particles increased their size at higher pH value. The morphology, adherence, and stability of these nanoparticles were investigated by scanning electron microscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy. The size of the chitosan/NaF nanoparticles was doubled after they were stored at 48C for 20 days, and then kept constant till 251 days, the examined time so far. These particles showed good stability in toothpaste lixivium after incubated at 608C for 30 days too. By contrast, the chitosan/cetylpyridiniumchloride nanoparticles were easy to form floccules in the toothpaste lixivium. The loaded toothpaste actives showed a sustained released behavior for at least 10 h. All the particles could adhere onto the tooth analogs such as hydroxyapatite discs and glass slides in a simulated brushing and rinsing process. In vitro cell culture did not find any cytotoxicity of the as-prepared chitosan nanoparticles.

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Section: Loading and Release Of Toothpaste Activesmentioning

confidence: 97%

Chitosan nanoparticles for loading of toothpaste actives and adhesion on tooth analogs

Liu

Chen

Mao

et al. 2007

J of Applied Polymer Sci

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“…As a result, chitosan was precipitated and recombinant human interleukin-2 was incorporated when CMs were formed. 63 Of note, this method is devoid of any crosslinking agent. …”

Section: Precipitation or Coacervation Methodsmentioning

confidence: 99%

Design and application of chitosan microspheres as oral and nasal vaccine carriers: an updated review

Islam¹,

Firdous²,

Choi³

et al. 2012

IJN

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Chitosan, a natural biodegradable polymer, is of great interest in biomedical research due to its excellent properties including bioavailability, nontoxicity, high charge density, and mucoadhesivity, which creates immense potential for various pharmaceutical applications. It has gelling properties when it interacts with counterions such as sulfates or polyphosphates and when it crosslinks with glutaraldehyde. This characteristic facilitates its usefulness in the coating or entrapment of biochemicals, drugs, antigenic molecules as a vaccine candidate, and microorganisms. Therefore, chitosan together with the advance of nanotechnology can be effectively applied as a carrier system for vaccine delivery. In fact, chitosan microspheres have been studied as a promising carrier system for mucosal vaccination, especially via the oral and nasal route to induce enhanced immune responses. Moreover, the thiolated form of chitosan is of considerable interest due to its improved mucoadhesivity, permeability, stability, and controlled/extended release profile. This review describes the various methods used to design and synthesize chitosan microspheres and recent updates on their potential applications for oral and nasal delivery of vaccines. The potential use of thiolated chitosan microspheres as next-generation mucosal vaccine carriers is also discussed.

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“…84 Delivery of growth factors, plasmids, and adenoviral vectors has also been reported. 84,[108][109][110][111][112][113][114][115][116][117][118][119][120][121][122][123][124][125] In contrast, hyaluronan HGs made by physical preparation only have been less extensively studied due to suboptimal mechanical properties, so that a mild chemical crosslinking step was added at the end of the preparation procedure. 84 However, physical gelation with/in presence of collagen, alginate, polylactide-based microspheres, copper ions, and applied for the restoration of vocal fold lamina propria, cartilage TE, and induction of neovascolarization have been reported.…”

Section: Ionic Interactionsmentioning

confidence: 99%