Controlled release of insulin from pH/temperature-sensitive injectable pentablock copolymer hydrogel

Huynh, Dai Phu; Im, Guang Jin; Chae, Su Young; Lee, Kang Choon; Lee, Sang Soo

doi:10.1016/j.jconrel.2009.02.021

Cited by 141 publications

(82 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PLGA Chondrocyte MPEG-PCL rBMSC, dexamethasone [104] FITC-BSA, BSA [105,106] Cholesterol end-capped star PEG-PLLA L929 cells [46] PEG/PPG/PHB BSA [48] Polyphosphazenes FITC-dextran, HSA [107] Doxorubicin, paclitaxel [108,112] FITC-albumin [109] Pancreatic islets, hepatocytes [110,111] C/GP Camptothecin, insulin [113,114] Bovine chondrocytes [115] pH/temperature-sensitive OSM-PCLA-PEG-PCLA-OSM Paclitaxel [116] hMSCs [117] PAE-PCL-PEG-PCL-PAE Insulin [82,118] (PCL-PEG-PCL-PAU) n Paclitaxel [86] (PEG-PAU) m Chlorambucil [87] PAA-PEG-PAA Flurbiprofen [90] PAE-PEG-PAE Lidocaine [89] matrices or cell growth depots. Table 1 summarizes the biomedical applications of the biodegradable injectable hydrogels.…”

Section: Hydrogel Types Polymer Delivery/applications Referencesmentioning

confidence: 99%

“…The physiological effects of pentablock copolymer/insulin injection were investigated in diabetic rats. [118] After a single injection into a diabetic rat, steady blood glucose levels were maintained for more than one week, without a decrease in body weight. The blood glucose levels and body weight showed a dose dependence of insulin loaded into the polymer.…”

Section: Ph/temperature-sensitive Block Copolymer Hydrogelsmentioning

confidence: 99%

See 1 more Smart Citation

Injectable Biodegradable Hydrogels

Nguyen

Lee

2010

Macromolecular Bioscience

Self Cite

409

341

View full text Add to dashboard Cite

Injectable biodegradable copolymer hydrogels, which exhibit a sol–gel phase transition in response to external stimuli, such as temperature changes or both pH and temperature (pH/temperature) alterations, have found a number of uses in biomedical and pharmaceutical applications, such as drug delivery, cell growth, and tissue engineering. These hydrogels can be used in simple pharmaceutical formulations that can be prepared by mixing the hydrogel with drugs, proteins, or cells. Such formulations are administered in a straightforward manner, through site‐specific control of release behavior, and the hydrogels are compatible with biological systems. This review will provide a summary of recent progress in biodegradable temperature‐sensitive polymers including polyesters, polyphosphazenes, polypeptides, and chitosan, and pH/temperature‐sensitive polymers such as sulfamethazine‐, poly(β‐amino ester)‐, poly(amino urethane)‐, and poly(amidoamine)‐based polymers. The advantages of pH/temperature‐sensitive polymers over simple temperature‐sensitive polymers are also discussed. A perspective on the future of injectable biodegradable hydrogels is offered.magnified image

show abstract

Section: Hydrogel Types Polymer Delivery/applications Referencesmentioning

confidence: 99%

Section: Ph/temperature-sensitive Block Copolymer Hydrogelsmentioning

confidence: 99%

Injectable Biodegradable Hydrogels

Nguyen

Lee

2010

Macromolecular Bioscience

Self Cite

409

341

View full text Add to dashboard Cite

show abstract

“…Such polymer solutions can be mixed with water-soluble bioactive reagents such as proteins, peptides, or living cells before injection, and form a hydrogel entrapping these reagents at the injection site in the body. If the polymer can be hydrolyzed to low-molecular-weight compounds that can be metabolized or excreted from the body, such biodegradable IP systems could potentially act as implantable minimally invasive sustained drug release systems [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation

Takata¹,

Takai²,

Yoshizaki

et al. 2017

Gels

View full text Add to dashboard Cite

Abstract:We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to the covalent bond formation through a thiol-ene reaction. In vitro sustained release of GLP-1 from an irreversible IP formulation (F(P1/D+PA 40 )) was observed compared with a reversible (physical gelation) IP formulation (F(P1)). Moreover, pharmaceutically active levels of GLP-1 were maintained in blood after subcutaneous injection of the irreversible IP formulation into rats. This system should be useful for the minimally invasive sustained drug release of peptide drugs and other water-soluble bioactive reagents.

show abstract

“…Huynh et al 75 developed a pH and temperature-sensitive hydrogel as a sustained injectable insulin delivery system. The in vivo release behavior indicated that insulin was maintained at a constant steady-state level for 15 days through a subcutaneously injection to male Sprague-Dawley rats.…”

Section: In Situ Forming Formulationsmentioning

confidence: 99%

Untitled

2012

IJPSR

View full text Add to dashboard Cite

show abstract

Controlled release of insulin from pH/temperature-sensitive injectable pentablock copolymer hydrogel

Cited by 141 publications

References 19 publications

Injectable Biodegradable Hydrogels

Injectable Biodegradable Hydrogels

Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation

Untitled

Contact Info

Product

Resources

About