Controlled release of doxorubicin from electrospun PEO/chitosan/graphene oxide nanocomposite nanofibrous scaffolds

Ardeshirzadeh, Behnaz; Anaraki, Nadia Aboutalebi; Irani, Mohammad; Rad, Leila Roshanfekr; Shamshiri, Soodeh

doi:10.1016/j.msec.2014.12.039

Cited by 159 publications

(79 citation statements)

References 29 publications

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“…When the concentration of DOX was 1.2 mg mL −1 , the DLC values of GO, GO‐CO and GO‐CO‐ γ ‐PGA were approximately 0.8915, 0.8534 and 1.1883 mg mg −1 , respectively. Therefore, after the modification of GO with CO and γ ‐PGA, loading capacity of the nanocarrier showed significant enhancement and became higher than those of reported drug vehicles such as PEO/CS/GO and CS/PLA/GO/TiO 2 . Notably, the UV‐Vis absorption spectra (Figure S4b) shows that GO‐CO‐ γ ‐PGA‐DOX contained the characteristic peaks of GO‐CO‐ γ ‐PGA and DOX.…”

Section: Resultsmentioning

confidence: 99%

Fabrication and Antitumor Mechanism of a Nanoparticle Drug Delivery System: Graphene Oxide/Chitosan Oligosaccharide/γ‐Polyglutamic Acid Composites for Anticancer Drug Delivery

et al. 2019

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This study focused on the design of a novel pH responsive nanoparticle drug delivery system (NDDS) with high biocompatibility and water solubility. The designed system was used for doxorubicin (DOX) delivery at tumor sites in a controlled manner. These innovative nanoparticles are soluble in physiological solutions besides water. In this study, pretreated γ‐polyglutamic acid (γ‐PGA) aqueous solutions were loaded into composites of graphene oxide (GO) covalently linked with chitosan oligosaccharide (CO) to fabricate GO‐CO‐γ‐PGA via amidation. The characterizations of the synthesized samples were carried out by using fourier transform infrared spectrometer (FTIR), X‐ray photoelectron spectrometer (XPS), ultraviolet– visible spectrophotometer (UV‐Vis), transmission electron microscopy (TEM), atomic force microscope (AFM) and zeta potential. Furthermore, drug loading and release behaviors from GO‐CO‐γ‐PGA were studied. The DOX loading in the constructed nanocarriers (GO‐CO‐γ‐PGA‐DOX) resulted in controlled and sustained release. The results of cell experiments revealed that the synthesized composites, which were easily transferred into cells, showed low toxicity and exhibited excellent antitumor effect due to its good connection with DOX. In addition, the composite nanoparticles caused the cell cycle arrest of Hela cells at the G2/M phase. Western blot results indicated that GO‐CO‐γ‐PGA‐DOX downregulated the expression of Bcl‐2 protein but upregulated Bax protein expression, which triggered the release of cytochrome C (Cytc). This condition further activated caspase‐3, cleaved the substrate of poly ADP‐ribose polymerase (PARP), and caused cell apoptosis. These results demonstrated that GO‐CO‐γ‐PGA‐DOX induces apoptosis via the intrinsic mitochondrial apoptotic pathway. Hence GO‐CO‐γ‐PGA composites have promising application in the field of biomedicine.

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Section: Resultsmentioning

confidence: 99%

Fabrication and Antitumor Mechanism of a Nanoparticle Drug Delivery System: Graphene Oxide/Chitosan Oligosaccharide/γ‐Polyglutamic Acid Composites for Anticancer Drug Delivery

et al. 2019

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“…They reduce the exposure of normal cells to the anticancer drugs. From our study, the approved anticancer drugs such as Doxorubicin [36,37,38,40,46,51,57,60], Paclitaxel [34,39,44],5-Fluorouracil [35,52,61], Daunorubicin [47,48], Oxaliplatin [40], Cispaltin [50] have been extensively explored.…”

Section: Resultsmentioning

confidence: 99%

“…The Doxorubicin-loaded PEO/CS/ GO nanofibers exhibited obvious cytotoxicity against A549 cells for longer time than free DOX due to its slower release. This promoted the electrospun PEO/CS/GO/ Doxorubicin nanofibrous in lung cancer treatment [37].…”

Section: Targeted Drug Deliverymentioning

confidence: 96%

Overview on in vitro and in vivo investigations of nanocomposite based cancer diagnosis and therapeutics

2015

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Cancer is the second leading cause of mortality around the globe, despite the various advancements in science. The success of the cancer treatment lies within early diagnosis and effective therapy making them inseparable. In recent years, there has been an extraordinary development in the field of nanomedicine with the development of new nanoparticles for the diagnosis and treatment of cancer. These researches are generally focused on creating novel nanocomposites for combating cancer. This review will serve as a one-stop arrangement for collating and providing future perspectives about the various nanocomposites based in vitro and in vivo investigations for cancer diagnosis and treatment. From our study, it is revealed that nanocomposite based diagnosis engrosses nanosensors for detection and conjugation of biomarkers, quantum dots, radiolabeling, delivery of contrast agent for better imaging of cancer development. In cancer therapeutics, nanocomposites hold enormous potential in maximizing the benefits of both targeted chemotherapy and photodynamic therapy. This review will encourage the need of in-depth molecular level examination in relation to the cytotoxicity and bio-distribution of the developed nanocomposite should be evaluated in the clinical setting for better understanding. These supplementary researches on nanoncology would help in personalizing cancer theranostics making nanooncology as the future trend.

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“…In the electric field, spherical drops within a needle become cones, and then fiber filaments extend from the cone tip. Electrospinning is a simple, effective, and widely available new processing technology for synthesizing nanofibers, in which a polymer fluid atomized by static electricity is moved a long distance, and finally stretched into fiber [31][32][33][34][35].…”

Section: Electrospinningmentioning

confidence: 99%

“…These fibers are promising for drug delivery systems, tissue engineering, and wound healing. Ardeshirzadeh et al [34] prepared a polyoxyethylene/CS/graphene nanofiber scaffold able to control the release of adriamycin. The nanofibers, obtained by electrospinning, had good stability and demonstrated drug transportation, and they also eliminated previous shortcomings, such as low solubility, stability, and poor mechanical properties, of electrospun CS.…”

Section: Electrospinningmentioning

confidence: 99%

A review: synthesis and applications of graphene/chitosan nanocomposites

Yuan¹,

Meng²,

Park³

2016

Carbon letters

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Recently, with continuous developments in the field of materials science, graphene oxide (GO) has emerged as a promising material with excellent electrical, thermal, mechanical, and optical properties, which play important roles in most fields. Researchers have achieved considerable progress with graphene. Chitosan (CS) is a natural polymer that has been studied intensively owing to its specific formation, high chemical resistance, and excellent physical properties. These outstanding properties have led to its universal use in applications such as textile fabrics, tissue engineering, medicine and health, coatings, and paints. By combining the advantages of GO and CS, different types of promising materials can be obtained. This review discusses the preparation of GO-CS fibers, hydrogel and aerogel, and the applications of GO-CS nanocomposites. In addition, directions for future research on graphene material composites are discussed.

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Controlled release of doxorubicin from electrospun PEO/chitosan/graphene oxide nanocomposite nanofibrous scaffolds

Cited by 159 publications

References 29 publications

Fabrication and Antitumor Mechanism of a Nanoparticle Drug Delivery System: Graphene Oxide/Chitosan Oligosaccharide/γ‐Polyglutamic Acid Composites for Anticancer Drug Delivery

Fabrication and Antitumor Mechanism of a Nanoparticle Drug Delivery System: Graphene Oxide/Chitosan Oligosaccharide/γ‐Polyglutamic Acid Composites for Anticancer Drug Delivery

Overview on in vitro and in vivo investigations of nanocomposite based cancer diagnosis and therapeutics

A review: synthesis and applications of graphene/chitosan nanocomposites

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