Controlled release of atenolol from the ethylene-vinyl acetate matrix

Effect of Polyunsaturated Fatty Acids and Some Conventional Penetration Enhancers on Transdermal Delivery of Atenolol

“…Chromatography was performed following a method reported by Kim and Shin (2004) and using a Jupiter Phenomenex C 18 R.P. (particle size 5 µm; 25 cm × 4.6 mm i.d; Phenomenex, Torrance, CA, USA).…”

Preparation, characterization and properties of partially hydrolyzed ethylene vinyl acetate copolymer films for controlled drug release

“…Previous studies have shown that the release of drugs from EVA films can be regulated by changing the vinyl acetate content (VAc) and drug loading dose (Arnold et al, 2008;Cho et al, 2005;Guo et al, 2007a;Kim and Shin, 2004;Shin and Lee, 2002). Furthermore, adding PEG to EVA films (Fishbein et al, 2001) and coating EVA films with polymer materials (Lesser et al, 1996;Tallury et al, 2007) can effectively increase and decrease the rate of drug release, respectively.…”

Formulation and optimization of controlled release mucoadhesive tablets of atenolol using response surface methodology

“…7,8 Accordingly, studies have been reported on regulation of drug release by formulating its diverse CR systems such as hydrophilic matrices, 9-11 osmotic pumps, 7,8,12,13 and transdermal drug delivery systems. 14 Response surface methodology (RSM) is a widely practiced approach in the development and optimization of drug delivery devices. [15][16][17][18][19][20] Based on the principal of design of experiments (DoE), the methodology encompasses the use of various types of experimental designs, generation of polynomial equations, and mapping of the response over the experimental domain to determine the optimum formulation(s).…”