Controlled release of anticancer drug Paclitaxel using nano-structured amphiphilic star-hyperbranched block copolymers

Abstract

In the present study, two amphiphilic star-hyperbranched copolymers, poly(methyl methacrylate)-b-poly(2-hydroxyethyl methacrylate) (PMMA-b-PHEMA), with different hydrophilic PHEMA segment content (PMMA-b-PHEMA-1, and PMMA-b-PHEMA-2) were synthesized and their drug loading and release profiles were examined by using paclitaxel (PTX) as a model drug. Drug loading capacity and encapsulation efficiency were found to be similar in both polymers. Encapsulation efficiency found to be prominent with 98% and 98.5% for PMMA-b-PHEMA-1 and PMMA-b-PHEMA-2, respectively. On the other hand, drug release behaviors were varied in favor of the block copolymer comprising shorter PHEMA chains (PMMAb-PHEMA-1). Additionally, to assess biological effects of PTX-loaded polymers, human non-small cell lung carcinoma (A549) cells were used. Cell viability and cell cycle analysis showed that both polymers were not toxic to the cells. Cytotoxic effects of PTX-loaded PMMA-b-PHEMA-1 on A 549 cells were higher (66.49% cell viability at 5.0 ng/mL PTX) than that of PMMA-b-PHEMA-2 (72.47% cell viability at 5.0 ng/mL PTX) consistent with the drug release experiments.

Hyperbranched Polymers by Light‐Induced Self‐Condensing Vinyl Polymerization

“…This way, amphiphilic star‐hyperbranched poly(methyl methacrylate)‐ block ‐poly(2‐hydroxyethyl methacrylate) (PMMA ‐b ‐PHEMA) possessing hydrophobic hyperbranched core and hydrophilic chains were obtained, which were used for drug delivery systems ( Scheme ) …”

Functional Surfaces Constructed with Hyperbranched Copolymers as Optical Imaging and Electrochemical Cell Sensing Platforms

“…The method is based on the reactivity difference of the photochemically generated radicals toward double and triple bonds . In another work, we have shown that hyperbranched poly(methyl methacrylate) (PMMA)‐ co ‐poly(2‐bromoethyl methacrylate) copolymers can be prepared by using Mn 2 (CO) 10 photochemistry which were further shown to be suitable materials for drug delivery systems …”

Controlled and sustained release of a corticosteroid drug from block copolymers synthetized by ATRP

“…In the literature, among the poly(methyl methacrylate)‐ b ‐poly(2‐hydroxyethyl methacrylate) (PMMA‐ b ‐PHEMA) copolymers‐based DDS, star‐shaped systems were synthesized by radical polymerization and tested for the release of anticancer drugs. Geyik et al used amphiphilic star‐hyperbranched copolymers based on PMMA‐ b ‐PHEMA to release paclitaxel, a chemotherapeutic agent . Seleci et al evaluated a nanostructured amphiphilic star‐hyperbranched PMMA‐ b ‐PHEMA block copolymer as DDS of the anticancer drug doxorobucin .…”