Controlled Release of Albumin from Chitosan-Alginate Microcapsules

Semi-permeable nanocapsules of konjac glucomannan–chitosan for enzyme immobilization

“…To the best of our knowledge, this is the first study to date to investigate the application of CKGM in enzyme immobilization. Chitosan is another natural polymer, which is cationic and produced by N-deacetylation of chitin, has attracted many attentions in protein drugs, drug delivery and controlled release (Carrara and Rubiolo, 1994;Huguet et al, 1994;Itoyama et al, 1994;Polk et al, 1994;Gaserod et al, 1999;Albarghouthi et al, 2000). It is an aminopolysaccharide and can gelate with CKGM to form nanocapsules due to electrostatic complexation.…”

Effect of Solvent Type and Drying Method on Protein Retention in Chitosan-Alginate Microcapsules

“…The choice of solvent in the preparation of coating solution is of particular importance because it affects the physicochemical characteristics of the encapsulating membrane and hence the final drug product. Polymer membrane parameters such as permeability, solubility and stability 3 as well as microcapsule properties such as size, swelling and drug release profile 5 have been reported to be influenced by the nature of the solvent used. Among the solvent properties that play a role in this regard are: viscosity, dielectric constant, polarity and pH 3, 5 & 6 .…”

“…Furthermore, because it is easily biodegradable, biocompatible and has great ease of chemical modification 7 , it has found a wide range of applications in pharmacy and medicine such as inhibition of tumor cells, acceleration of wound healing and reduction of blood cholesterol level 8 . It has also been investigated as a suitable polymer coating for oral delivery of proteins/peptide drugs 2,[4][5][6] as well as immobilization/delivery of living cells 9 & 10 . Chitosan is insoluble in aqueous, alkali and organic solvents.…”

“…However, it is soluble in acid solutions when the pH is less than 6.0. Acetic acid and to a lesser extent, formic acid, are often commonly used for preparing chitosan solutions for encapsulation processes [5][6][7] .…”

The Effects of Poly(Ethyleneimine) (PEI) Molecular Weight on Reinforcement of Alginate Hydrogels

“…Examples of this apHydrogel-based materials have found broad application as cell encapsulation matrices, drug delivery devices, proach are alginate hydrogels stabilized with chitosan (14), polylysine (8), gelatin (9), or poly(ethyleneimine) (PEI) (7). and three-dimensional cell transplantation vehicles, due to their many advantageous features (i.e., good biocomIn these examples, a polyelectrolyte complex is formed between the two oppositely charged polymers.…”