Controlled-release biodegradable nanoparticles: From preparation to vaginal applications

Martínez-Pérez, Beatriz; Quintanar‐Guerrero, David; Tapia-Tapia, Melina; Tamayo, R. Cisneros; Zambrano-Zaragoza, María L.; Alcalá-Alcalá, Sergio; Mendoza‐Muñoz, Néstor; Piñón-Segundo, Elizabeth

doi:10.1016/j.ejps.2017.11.029

Cited by 57 publications

(25 citation statements)

References 56 publications

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“…Positively charged NPs can in fact more efficiently interact with negatively charged cellular membranes triggering cell uptake [ 5 , 6 , 7 , 8 ]. From this perspective, the coating with chitosan is in many cases a first choice for its low cost, good biocompatibility, and interesting biological properties such as mucoadhesion [ 9 ], that in turn can support the efficiency of nanosystems for mucosal vaccination [ 10 , 11 ]. Moreover, chitosan coated PLGA NPs are described as useful tools to improve transfection in nucleic acids delivery [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Chitosan Oleate Salt as an Amphiphilic Polymer for the Surface Modification of Poly-Lactic-Glycolic Acid (PLGA) Nanoparticles. Preliminary Studies of Mucoadhesion and Cell Interaction Properties

et al. 2018

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Most of the methods of poly-lactic-glycolic acid (PLGA) preparation involve the passage through the emulsification of a PLGA organic solution in water followed by solvent evaporation or extraction. The choice of the droplet stabilizer during the emulsion step is critical for the dimensions and the surface characteristics of the nanoparticles (NPs). In the present work, a recently described ionic amphiphilic chitosan derivative, chitosan oleate salt (CS-OA), was proposed for the first time to prepare PLGA NPs. A full factorial design was used to understand the effect of some formulation and preparation parameters on the NP dimensions and on encapsulation efficiency (EE%) of Nile red, used as a tracer. On the basis of the DoE study, curcumin loaded NPs were prepared, having 329 ± 42 nm dimensions and 68.75% EE%. The presence of a chitosan coating at the surface was confirmed by positive zeta potential and resulted in mucoadhesion behavior. The expected improvement of the interaction of the chitosan surface modified nanoparticles with cell membrane surface was confirmed in Caco-2 cell culture by the internalization of the loaded curcumin.

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Section: Introductionmentioning

confidence: 99%

Chitosan Oleate Salt as an Amphiphilic Polymer for the Surface Modification of Poly-Lactic-Glycolic Acid (PLGA) Nanoparticles. Preliminary Studies of Mucoadhesion and Cell Interaction Properties

et al. 2018

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“…Exogenous stimuli (electric pulse, temperature, ultrasound, magnetic field, etc) and Endogenous stimuli (hormone level, pH alterations, enzyme concentration, small biomolecules, glucose etc). 9 Due to its specific action, smart drug delivery system has many applications in the treatment of cancer, cardiovascular diseases, diabetes, tumors and intestinal inflammation. It has also proved to be beneficial in colon specific smart drug delivery system.…”

Section: Review Articlementioning

confidence: 99%

Stimuli-Responsive Polymeric Nanosystem for Colon Specific Drug Delivery

2019

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An ideal colon specific drug delivery system needs to perform multiple functions like greater bio availability, less toxicity and higher therapeutic efficacy, all of which require high degree of smartness. This article focuses on the overview of the stimuli-responsive polymers and various nanodrug delivery systems which have found applications in colon specific delivery of drugs as this system provide a link between therapeutic need and drug delivery. These polymers exhibit a non-linear response to a small stimulus leading to a macroscopic alteration in their structure/properties. Stimuli responsive polymers display a significant physio chemical change in response to small changes in their environment (temperature, pH, light etc.). Colonic drug delivery has gained increased importance in treating diseases like Crohn’s disease, ulcerative colitis, colon cancer etc. The expansion in the development of polymers based system with greater flexibility, versatility and unexplored potential enables new opportunities for them in uplifting bio medicine. Applying the concepts of smartness in the context of clinically relevant therapeutic and diagnostic systems, it can prelude in a new era of ‘smart’ therapeutics that can improve the health care fields. In particular, due to its high sensitivity to the stimuli, this system has been identified as a sensible platform for releasing drug at suitable site and at appropriate time.

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“…In our research group, PLGA nanoparticles were recently developed with chitosan surface modification in order to control vaginal clotrimazole delivery for the treatment of vaginal infections generated by Candida albicans [ 42 ]. Microbiological studies indicated that clotrimazole (at a level of 10 µg/mL) increased its effectiveness against C. albicans by four-fold when incorporated into PLGA-chitosan nanoparticles.…”

Section: Synthetic and Biodegradable Polymer-based Nanoparticlesmentioning

confidence: 99%

Approaches in Polymeric Nanoparticles for Vaginal Drug Delivery: A Review of the State of the Art

Leyva-Gómez

Piñón-Segundo

Mendoza‐Muñoz

et al. 2018

IJMS

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The vagina is a region of administration with a high contact surface to obtain local or systemic effects. This anatomical area represents special interest for government health systems for different sexually transmitted infections. However, the chemical changes of the vagina, as well as its abundant mucus in continuous exchange, act as a barrier and a challenge for the development of new drugs. For these purposes, the development of new pharmaceutical forms based on nanoparticles has been shown to offer various advantages, such as bioadhesion, easy penetration of the mucosa, and controlled release, in addition to decreasing the adverse effects of conventional pharmaceutical forms. In order to obtain nanoparticles for vaginal administration, the use of polymers of natural and synthetic origin including biodegradable and non-biodegradable systems have gained great interest both in nanospheres and in nanocapsules. The main aim of this review is to provide an overview of the development of nanotechnology for vaginal drug release, analyzing the different compositions of polymeric nanoparticles, and emphasizing new trends in each of the sections presented. At the end of this review, a section analyzes the properties of the vehicles employed for the administration of nanoparticles and discusses how to take advantage of the properties that they offer. This review aims to be a reference guide for new formulators interested in the vaginal route.

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Controlled-release biodegradable nanoparticles: From preparation to vaginal applications

Cited by 57 publications

References 56 publications

Chitosan Oleate Salt as an Amphiphilic Polymer for the Surface Modification of Poly-Lactic-Glycolic Acid (PLGA) Nanoparticles. Preliminary Studies of Mucoadhesion and Cell Interaction Properties

Chitosan Oleate Salt as an Amphiphilic Polymer for the Surface Modification of Poly-Lactic-Glycolic Acid (PLGA) Nanoparticles. Preliminary Studies of Mucoadhesion and Cell Interaction Properties

Stimuli-Responsive Polymeric Nanosystem for Colon Specific Drug Delivery

Approaches in Polymeric Nanoparticles for Vaginal Drug Delivery: A Review of the State of the Art

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