Controlled Propulsion and Cargo Transport of Rotating Nickel Nanowires near a Patterned Solid Surface

Zhang, Zifeng; Petit, Tristan; Lü, Yang; Kratochvil, Bradley E.; Peyer, Kathrin E.; Pei, R.; Lou, Jun; Nelson, Bradley J.

doi:10.1021/nn101861n

Cited by 259 publications

(249 citation statements)

References 30 publications

Supporting

Mentioning

243

Contrasting

Order By: Relevance

“…(iii) Exploiting novel magnetic materials whose magnetic properties are superior to those of iron-oxide superparamagnetic nanoparticles (104). The hurdle in this approach is testing and ensuring the biocompatibility of these material as well as developing high yield fabrication techniques.…”

Section: Discussionmentioning

confidence: 99%

MRI-Guided Nanorobotic Systems for Therapeutic and Diagnostic Applications

Vartholomeos

Fruchard

Ferreira

et al. 2011

Annu. Rev. Biomed. Eng.

View full text Add to dashboard Cite

International audienceThis review presents the state of the art of magnetic resonance imaging(MRI)-guided nanorobotic systems that can perform diagnostic, curative,and reconstructive treatments in the human body at the cellular and subcellular levels in a controllable manner. The concept of an MRI-guided nanorobotic system is based on the use of an MRI scanner to induce the required external driving forces to propel magnetic nanocapsules to a specific target. It is an active targeting mechanism that provides simultaneous propulsion and imaging capabilities, which allow the implementation of real-time feedback control of the targeting process. The architecture of the system comprises four main modules: (a) the nanocapsules, (b) the MRI propulsion module, (c) theMRI trackingmodule (for image processing), and (d ) the controller module. A key concept is the nanocapsule technology, which is based on carriers such as liposomes, polymermicelles, gold nanoparticles, quantum dots, metallic nanoshells, and carbon nanotubes. Descriptions of the significant challenges faced by theMRI-guided nanorobotic system are presented, and promising solutions proposed by the involved research community are discussed. Emphasis is placed on reviewing the limitations imposed by the scaling effects that dominate within the blood vessels and also on reviewing the control algorithms and computational tools that have been developed for real-time propulsion and tracking of the nanocapsules

show abstract

Section: Discussionmentioning

confidence: 99%

MRI-Guided Nanorobotic Systems for Therapeutic and Diagnostic Applications

Vartholomeos

Fruchard

Ferreira

et al. 2011

Annu. Rev. Biomed. Eng.

View full text Add to dashboard Cite

show abstract

“…Besides cell manipulation, targeted drug delivery is a potential application that is being extensively studied: it has been reported Ni NWs are capable of transporting colloidal cargo when under a uniform rotating magnetic field (Zhang et al 2010). Further, studies on destruction of living cells have paved the way for possible cancer treatment therapies.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and intracellular dissolution of nickel nanowires

Perez

Contreras²,

Vilanova

et al. 2016

Nanotoxicology

View full text Add to dashboard Cite

The assessment of cytotoxicity of nanostructures is a fundamental step for their development as biomedical tools. As widely used nanostructures, nickel nanowires (Ni NWs) seem promising candidates for such applications. In this work, Ni NWs were synthesized and then characterized using vibrating sample magnetometry, energy dispersive X-Ray analysis and electron microscopy. After exposure to the NWs, cytotoxicity was evaluated in terms of cell viability, cell membrane damage and induced apoptosis/necrosis on the model human cell line HCT 116. The influence of NW to cell ratio (10:1 to 1000:1) and exposure times up to 72 hours was analyzed for Ni NWs of 5.4 µm in length, as well as for Ni ions. The results show that cytotoxicity markedly increases past 24 hours of incubation. Cellular uptake of NWs takes place through the phagocytosis pathway, with a fraction of the dose of NWs dissolved inside the cells. Cell death results from a combination of apoptosis and necrosis, where the latter is the outcome of the secondary necrosis pathway. The cytotoxicity of Ni ions and Ni NWs dissolution studies suggest a synergistic toxicity between NW aspect ratio and dissolved Ni, with the cytotoxic effects markedly increasing after 24 hours of incubation.Just Accepted by Nanotoxicology © 2015 Taylor & Francis. This provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon.DISCLAIMER: The ideas and opinions expressed in the journal's Just Accepted articles do not necessarily reflect those of Taylor & Francis (the Publisher), the Editors or the journal. The Publisher does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of the material contained in these articles. The reader is advised to check the appropriate medical literature and the product information currently provided by the manufacturer of each drug to be administered to verify the dosages, the method and duration of administration, and contraindications. It is the responsibility of the treating physician or other health care professional, relying on his or her independent experience and knowledge of the patient, to determine drug dosages and the best treatment for the patient. Just Accepted articles have undergone full scientific review but none of the additional editorial preparation, such as copyediting, typesetting, and proofreading, as have articles published in the traditional manner. There may, therefore, be errors in Just Accepted articles that will be corrected in the final print and final online version of the article. Any use of the Just Accepted articles is subject to the express understanding that the papers have not yet gone through the full quality control process prior to publication. Cytotoxicity and intracellular dissolution of nickel nanowiresJose E. Perez 1, 2 , Maria F. Contreras 1 , Enrique Vilanova 2 , Laura P. Felix 1, 2 , Michael B.

show abstract

“…The driving force that propels the rod-shaped particles arises from diffusiophoresis or self-electrophoresis by a catalytic reaction with a chemical composition gradient along a particle. [7][8][9][10] Since then, several research groups have attempted to prepare nano/microsized motors that exhibit regulated motion (e.g., translation, spin, and rotation) by other mechanisms such as microbubble, [11][12][13][14] magnetic, 15,16 and ultrasound 17 propulsions. Because these minute systems have ultralow Reynolds numbers (Re 1), they need a continuous driving force or torque to maintain their motions.…”

Section: Introductionmentioning

confidence: 99%

Catalytic micromotor generating self-propelled regular motion through random fluctuation

Yamamoto

Mukai

Okita

et al. 2013

The Journal of Chemical Physics

View full text Add to dashboard Cite

Most of the current studies on nano/microscale motors to generate regular motion have adapted the strategy to fabricate a composite with different materials. In this paper, we report that a simple object solely made of platinum generates regular motion driven by a catalytic chemical reaction with hydrogen peroxide. Depending on the morphological symmetry of the catalytic particles, a rich variety of random and regular motions are observed. The experimental trend is well reproduced by a simple theoretical model by taking into account of the anisotropic viscous effect on the self-propelled active Brownian fluctuation.

show abstract

Controlled Propulsion and Cargo Transport of Rotating Nickel Nanowires near a Patterned Solid Surface

Cited by 259 publications

References 30 publications

MRI-Guided Nanorobotic Systems for Therapeutic and Diagnostic Applications

MRI-Guided Nanorobotic Systems for Therapeutic and Diagnostic Applications

Cytotoxicity and intracellular dissolution of nickel nanowires

Catalytic micromotor generating self-propelled regular motion through random fluctuation

Contact Info

Product

Resources

About