Controlled Production of Emulsions Using a Crossflow Membrane

Peng, S. J.; Williams, Richard A

doi:10.1002/(sici)1521-4117(199802)15:1<21::aid-ppsc21>3.0.co;2-t

Cited by 34 publications

(22 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The transmembrane pressure controls the size of the droplet formed in membrane emulsification process. With the increase in transmembrane pressure, several researchers (Katoh et al, 1996;Peng and Williams, 1998;Schröder and Schubert, 1999) have observed the increase in droplet diameter while others (Abrahamse et al, 2002;Vladisavljevic and Schubert, 2003;Vladisavljevic et al, 2004) have observed the decrease in droplet diameter. The variation in droplet diameter with transmembrane pressure results the wide range of droplet size distribution (Abrahamse et al, 2002;Vladisavljevic et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Numerical Simulation of Droplet Dynamics in Membrane Emulsification Systems

Pathak¹

2012

Numerical Simulation - From Theory to Industry

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Numerical Simulation of Droplet Dynamics in Membrane Emulsification Systems

Pathak¹

2012

Numerical Simulation - From Theory to Industry

View full text Add to dashboard Cite

“…Shear induced droplet formation describes the condition where the shear stress affects the size and distribution of the droplets. It has been modelled using an algebraic torque balance equation (TBE) and a force balance (FBE) along the droplet contact line located around the membrane pore border [12][13][14][15]. During the detachment process, a number of forces have been identified; it has been shown that for micron scale droplets the inertia and buoyancy forces are approximately 9 and 6 orders of magnitude smaller, respectively, than the drag due to shear at the membrane surface and therefore can be neglected in the force balance type models [12,14].…”

Section: Introductionmentioning

confidence: 99%

Membrane emulsification using membranes of regular pore spacing: Droplet size and uniformity in the presence of surface shear

Egidi

Gasparini

Holdich

et al. 2008

Journal of Membrane Science

View full text Add to dashboard Cite

During membrane emulsification it is shown that the size of the drops formed at the membrane surface may increase with increasing dispersed phase injection rate through the membrane, or it may decrease, depending on the prevailing conditions. This is illustrated using a stirrer positioned above a flat disc membrane with a regular array of pores of 20 μm diameter and a spacing between the pores of 80 μm and another membrane of 200 μm pore spacing. In the former case an additional mechanism for drop detachment is the push-off force, which is determined by the geometry of the drops as they deform at the membrane surface. In the force balance, the push-off force may be added to the shear-drag force to cause drop detachment. In the case of the 200 μm pore spaced membrane this force is much less prominent. The capillary-shear model has been modified to include this push-off force. The study required the use of very low dispersed phase injection rates and very high rates.Hence, two different types of pumps were used to provide these: a peristaltic and syringe pumps. A small study comparing the drop size, and size distributions, showed that the pump type did not influence the drops produced by the membrane emulsification process. keywords emulsification, stirred cell, sieve-membrane, force balance, push-off force 2

show abstract

“…However, the use of such microfluidic devices is limited by the low flow rates applied generating only very small quantities of particles and with limited scale up possibilities. Another approach, membrane emulsification [16] overcomes some of these limitations by offering the possibility of generating higher quantities of particles, while still maintaining a high control over process parameters, and generating monodispersed emulsions. Several devices coupled with membrane emulsification have been employed for the production of monodispersed microspheres using gas pressure, usually nitrogen, to disperse an aqueous phase into the oil phase [17][18][19].…”

Section: +mentioning

confidence: 99%

Membrane emulsification for the production of uniform poly-N-isopropylacrylamide-coated alginate particles using internal gelation

Hanga¹,

Holdich²

2014

Chemical Engineering Research and Design

View full text Add to dashboard Cite

Alginate particles, crosslinked by calcium ions, have a number of potential biopharmaceutical industry applications due to the biocompatibility of the materials used and formed. One such use is as microcarriers for cell attachment, growth and then detachment without the use of proteolytic enzymes. A straightforward and reproducible method for producing uniform calcium alginate particles with controllable median diameters which employs membrane emulsification and internal gelation (solid particles contained in the dispersed phase) is demonstrated, as well as functionalization of the resulting beads with amine terminated poly N-isopropylacrylamide (pNIPAM) to form temperature responsive particles, by taking advantage of the electrostatic interaction between the carboxyl groups of the alginate and amino groups of the modified pNIPAM. Cell attachment, growth and detachment capabilities of these core-shell structures were assessed and successfully demonstrated by using phase contrast microscopy and fluorescent staining with calcein-AM and ethidium homodimer-1. *Manuscript Click here to view linked ReferencesPage 2 of 40The formulation used for the alginate particles avoided non-GRAS chemicals by only using food grade and pharmaceutical grade reagents. The median particle size was controllable within the range between 55 µm to 690 µm and the size distributions produced were very narrow: 'span' values as low as 0.2. When using a membrane pore size of 20 µm no membrane blockage by the suspended calcium carbonate necessary for internal gelation of the alginate particles was observed. Membrane pore openings with diameters of 5 and 10 µm were also tested, but blocked with the 2.3 µm median diameter calcium carbonate solids.

show abstract

Controlled Production of Emulsions Using a Crossflow Membrane

Cited by 34 publications

References 3 publications

Numerical Simulation of Droplet Dynamics in Membrane Emulsification Systems

Numerical Simulation of Droplet Dynamics in Membrane Emulsification Systems

Membrane emulsification using membranes of regular pore spacing: Droplet size and uniformity in the presence of surface shear

Membrane emulsification for the production of uniform poly-N-isopropylacrylamide-coated alginate particles using internal gelation

Contact Info

Product

Resources

About