Controlled Penicillin Anaphylaxis Leading to Desensitization

Allopurinol Sensitivity in a Patient With Chronic Tophaceous Gout: Success of Intravenous Desensitization After Failure of Oral Desensitization

“…The intravenous method of drug desensitization has been used with some success in the past, primarily in patients with penicillin allergy (10)(11)(12). The intravenous route, however, has largely been replaced by oral desensitization, which is generally more effective and less likely to produce serious reactions (10).…”

Immediate hypersensitivity reactions to penicillin and related antibiotics

“…Review ofthe literature has suggested that parenteral desensitization results in a higher rate of acute allergic reactions [52]. Nevertheless, most patients can also be safely desensitized by the parenteral route, as indicated by the experience of Graybill et al, [56]. Recently, successful intravenous desensitization in 12 patients was reported [57].…”

Desensitization with Antibiotics

“…Penicillin desensitization was first reported in 1946 [10] and in the ensuing three decades there were a number of additional published case reports [11][12][13][14][15] . Most of these procedures involved parenteral administration of the antibiotic and were associated with significant allergic reactions either during or immediately after the procedure.…”

“…In order to maintain the desensitized state, patients must continue treatment with penicillin. Unless a long-acting preparation (such as benzathine penicillin G) is used, this typically translates to oral penicillin taken 2-3 times daily [4,10,13,[17][18][19] . Discontinuation of penicillin treatment following successful desensitization causes a reversal of the state of tolerance and again places the patient at risk of penicillin-induced anaphylaxis.…”