Controlled insulin release from glucose-sensitive self-assembled multilayer films based on 21-arm star polymer

Chen, Xingyu; Wu, Wei; Guo, Zhizhang; Xin, Jianyu; Li, Jianshu

doi:10.1016/j.biomaterials.2010.11.002

Cited by 126 publications

(111 citation statements)

References 40 publications

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“…In the second strategy, drugs are integrated into the macroscopic planar LbL films. They are released via diffusion 13,14 or the degradation of one of the film components. 15−17 For example, LbL films have been fabricated from siRNA (drug) and degradable poly(β-amino ester)s. siRNA was released upon the degradation of poly(β-amino ester).…”

Section: ■ Introductionmentioning

confidence: 99%

Release of Polyphenolic Drugs from Dynamically Bonded Layer-by-Layer Films

Zhou

Chen

Tian

et al. 2013

ACS Appl. Mater. Interfaces

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Layer-by-layer (LbL) assembled films have been exploited for surface-mediated drug delivery. The drugs loaded in the films were usually released via diffusion or the degradation of one of the film components. Here we demonstrate that drug release can also be achieved by exploiting the dynamic nature of hydrogen-bonded LbL films. The films were fabricated from tannic acid (TA), a model polyphenolic drug, and poly(vinyl pyrrolidone) (PVPON). The driving force for the film buildup is the hydrogen bonding between the two components, which was confirmed by Fourier transform infrared (FTIR) spectra. The film growth is linear, and the growth rate of the film decreases with increasing assembly temperature. Because of the reversible/dynamic nature of hydrogen bonding, when soaked in aqueous solutions, the PVPON/TA films disassemble gradually and thus release TA to the media. The release rate of TA increases with increasing pH and temperature but decreases with increasing ionic strength. Scanning electron microscopy (SEM) studies on the surface morphology of the film during TA release reveal that the film surface becomes smoother and then rougher again because of the dewetting of the film. The released TA can scavenge ABTS +• cation radicals, indicating it retains its antioxidant activity, a major biological activity of polyphenols.

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Section: ■ Introductionmentioning

confidence: 99%

Release of Polyphenolic Drugs from Dynamically Bonded Layer-by-Layer Films

Zhou

Chen

Tian

et al. 2013

ACS Appl. Mater. Interfaces

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“…Considering the structure PDMAEMA, the tertiary amine group PDMAEMA a weak electrolyte. Since PDMAEMA is a weak polyelectrolyte, the charge of the molecules depends highly on the pH of the 03001-p.2 polymer solution [5]. In contrast to PAA, PDMAEMA becomes charged at a lower pH environment.…”

Section: Ph Responsiveness Of the Selected Polymersmentioning

confidence: 99%

“…Films were fabricated using layer-by-layer deposition [5,6]. For drug release studies, deposition was done on glass substrates.…”

Section: Fabrication Of Glucose-sensitive Insulinloaded Filmsmentioning

confidence: 99%

Fabrication of Glucose-Sensitive Layer-by-Layer Films for Potential Controlled Insulin Release Applications

Talusan

Usman

Payawan

2015

MATEC Web of Conferences

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Abstract. Self-regulated drug delivery systems (DDS) are potential alternative to the conventional method of introducing insulin to the body due to their controlled drug release mechanism. In this study, Layer-by-Layer technique was utlized to manufacture drug loaded, pH responsive thin films. Insulin was alternated with pH-sensitive, [2-(dimethyl amino) ethyl aminoacrylate] (PDMAEMA) and topped of with polymer/glucose oxidase (GOD) layers. Similarly, films using a different polymer, namely Poly(Acrylic Acid) (PAA) were also fabricated. Exposure of the films to glucose solutions resulted to the production of gluconic acid causing a polymer conformation change due to protonation, thus releasing the embedded insulin. The insulin release was monitored by subjecting the dipping glucose solutions to Bradford Assay. Films exhibited a reversal in drug release profile in the presence of glucose as compared to without glucose. PAA films were also found out to release more insulin compared to that of the PDMAEMA films.The difference in the profile of the two films were due to different polymer-GOD interactions, since both films exhibited almost identical profiles when embedded with Poly(sodium 4-styrenesulfonate) (PSS) instead of GOD.

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“…In this investigation, bovine insulin was non-covalently bound to detonated nanodiamonds via physical adsorption in an aqueous solution, which demonstrated pH-dependent desorption and significant insulin release in alkaline environments of sodium hydroxide. In another investigation (Chen et al, 2011), controlled release, glucose responsive, self-assembled multilayer films of insulin have developed for installation beneath the skin. This multilayer film showed continuous release of insulin in vivo after being subcutaneously implanted in streptozotocin-induced diabetic rats and reduced blood glucose level for at least two weeks.…”

Section: Miscellaneous Systemsmentioning

confidence: 99%

“…Proved as an ideal alternative to the injectables (Rastogi et al, 2010b), Controlled release for at least 8 h (Rastogi et al, 2010a) Glimiperide Enhanced in vivo hypoglycemic efficacy (Ahmed et al, 2014) Implant Insulin Sustained effect for at least 15 days (Kofuji et al, 2005;Chen et al, 2011) Individuals may face discomfort and sometime rejection by body defence mechanism (Coelho et al, 2010) Requires specific medical expertise for implantation Usually preferred where long term therapy is required Nanodiamond Insulin Improved systemic availability (Shimkunas et al, 2009) Chemical mediated desorption is required to bring the drug in active form (Shimkunas et al, 2009). Microgel beads Insulin Sustained release (Nishimura et al, 2012) - …”

Section: Insulinmentioning

confidence: 99%

Novel drug delivery system: an immense hope for diabetics

et al. 2014

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Context: Existing medication systems for the treatment of diabetes mellitus (DM) are inconvenient and troublesome for effective and safe delivery of drugs to the specific site. Therefore, investigations are desired to deliver antidiabetics using novel delivery approaches followed by their commercialization. Objective: The present review aims to provide a compilation on the latest development in the field of novel drug delivery systems (NDDSs) for antidiabetics with special emphasis on particulate, vesicular and miscellaneous systems. Methods: Review of literature (restricted to English language only) was done using electronic databases like Pubmed Õ and Scirus, i.e. published during [2005][2006][2007][2008][2009][2010][2011][2012][2013]. The CIMS/MIMS India Medical Drug Information eBook was used regarding available marketed formulation of antidiabetic drugs. Keywords used were ''nanoparticle'', ''microparticle'', ''liposomes'', ''niosomes'', ''transdermal systems'', ''insulin'', ''antidiabetic drugs'' and ''novel drug delivery systems''. Single inclusion was made for one article. If in vivo study was not done then article was seldom included in the manuscript. Results: The curiosity to develop NDDSs of antidiabetic drugs with special attention to the nanoparticulate system followed by microparticulate and lipid-based system is found to emerge gradually to overcome the problems associated with the conventional dosage forms and to win the confidence of end users towards the higher acceptability. Conclusion: In the current scientific panorama when the area of novel drug delivery system has been recognized for its palpable benefits, unique potential of providing physical stability, sustained and site-specific drug delivery for a scheduled period of time can open new vistas for precise, safe and quality treatment of DM.

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Controlled insulin release from glucose-sensitive self-assembled multilayer films based on 21-arm star polymer

Cited by 126 publications

References 40 publications

Release of Polyphenolic Drugs from Dynamically Bonded Layer-by-Layer Films

Release of Polyphenolic Drugs from Dynamically Bonded Layer-by-Layer Films

Fabrication of Glucose-Sensitive Layer-by-Layer Films for Potential Controlled Insulin Release Applications

Novel drug delivery system: an immense hope for diabetics

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