Controlled generation of single microbubbles

Kim, Yeo Cheon; Dang, Bac Van; Taylor, Robert A.; Barber, Tracie

doi:10.1007/s00348-021-03324-2

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…In some practical applications, an additional droplet generation function is needed in a fabricated microfluidic chip without redesigning or fabricating a new chip for the application convenience. For example, a droplet generation function is needed in the downstream operations for multiple-functional chips or organs-on-chips with complex microchannel structures. , To visualize the flow field, Kim et al designed a coflow device by using an inserted micropipette to generate microbubbles, which size can be controlled by adjusting the gas injection pressure. Moreover, the dynamic evolution behaviors of the two-phase interface during droplet formation and the droplet generation mechanism should be further studied. ,,− Inspired by previous studies, − in this study, we examined the feasibility of an easy method for droplet generation by inserting a glass capillary into a microchannel from the vertical direction of a fabricated poly(dimethylsiloxanes) (PDMS) microfluidic chip.…”

Section: Introductionmentioning

confidence: 99%

“…For example, a droplet generation function is needed in the downstream operations for multiplefunctional chips or organs-on-chips with complex microchannel structures. 44,45 To visualize the flow field, Kim et al 46 designed a coflow device by using an inserted micro-pipette to generate microbubbles, which size can be controlled by adjusting the gas injection pressure. Moreover, the dynamic evolution behaviors of the two-phase interface during droplet formation and the droplet generation mechanism should be further studied.…”

Section: Introductionmentioning

confidence: 99%

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Easy Generation of Droplets in a Capillary Inserted Microchannel

Shen,

Chen,

et al. 2024

Ind. Eng. Chem. Res.

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Droplet microfluidics has received increasing attention over the past decade. This study proposes an easy method for droplet generation in microchannels by inserting a glass capillary into a microfluidic chip at required positions. The influences of the capillary insertion depth (0, 60, and 120 μm), capillary inner diameter (50, 75, and 100 μm), and two-phase flow rate ratios (2–12) on the generated droplet length were investigated. The evolution of the two-phase interface during droplet formation is observed in detail, which undergoes three successive stages: head formation, head filling, and neck breakage. Three neck breakage modes were identified as the squeezing, transition, and dripping modes, and the forces acting on the droplets were analyzed. The results show that the proposed capillary-based method can facilitate the generation of droplets in fabricated microfluidic chips over a wide range of two-phase flow rate ratios.

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