In this paper, we introduce controlled frames in Hilbert C *modules and we show that they share many useful properties with their corresponding notions in Hilbert space. Next, we give a characterization of controlled frames in Hilbert C * -module. Also multiplier operators for controlled frames in Hilbert C * -modules will be defined and some of its properties will be shown. Finally, we investigate weighted frames in Hilbert C * -modules and verify their relations to controlled frames and multiplier operators.2010 Mathematics Subject Classification. Primary 42C15; Secondary 46L08, 42C40, 47A05.