Controlled electrochemical synthesis of new rare earth metal lutetium hexacyanoferrate on reduced graphene oxide and its application as a salicylic acid sensor

Devadas, Balamurugan; Madhu, Rajesh; Chen, Shen‐Ming; Yeh, Huai-Tse

doi:10.1039/c4tb01325e

Cited by 15 publications

(8 citation statements)

References 60 publications

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“…As can be seen in this figure, a large cathodic peak is located between −1.0 and −1.5 V, disappearing after several cycles. This peak can be attributed to the electrochemical reduction of the functional groups, mainly oxygenated groups which are present at the GO basal plane [ 24 , 25 , 26 , 27 ]. Therefore, after a few CV cycles, GO was reduced, rGO was obtained, and subsequently, the electric properties improved [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

Detection of a Double-Stranded MGMT Gene Using Electrochemically Reduced Graphene Oxide (ErGO) Electrodes Decorated with AuNPs and Peptide Nucleic Acids (PNA)

Safarzadeh

Pan

2022

Biosensors

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The ability to detect double-stranded DNA (dsDNA) as a biomarker without denaturing it to single-stranded DNA (ss-DNA) continues to be a major challenge. In this work, we report a sandwich biosensor for the detection of the ds-methylated MGMT gene, a potential biomarker for brain tumors and breast cancer. The purpose of this biosensor is to achieve simultaneous recognition of the gene sequence, as well as the presence of methylation. The biosensor is based on reduced graphene oxide (rGO) electrodes decorated with gold nanoparticles (AuNPs) and uses Peptide Nucleic Acid (PNA) that binds to the ds-MGMT gene. The reduction of GO was performed in two ways: electrochemically (ErGO) and thermally (TrGO). XPS and Raman spectroscopy, as well as voltammetry techniques, showed that the ErGO was more efficiently reduced, had a higher C/O ratio, showed a smaller crystallite size of the sp2 lattice, and was more stable during measurement. It was also revealed that the electro-deposition of the AuNPs was more successful on the ErGO surface due to the higher At% of Au on the ErGO electrode. Therefore, the ErGO/AuNPs electrode was used to develop biosensors to detect the ds-MGMT gene. PNA, which acts as a bio-recognition element, was used to form a self-assembled monolayer (SAM) on the ErGO/AuNPs surface via the amine-AuNPs interaction, recognizing the ds-MGMT gene sequence by its invasion of the double-stranded DNA and the formation of a triple helix. The methylation was then detected using biotinylated-anti-5mC, which was then measured using the amperometric technique. The selectivity study showed that the proposed biosensor was able to distinguish between blank, non-methylated, non-complementary, and target dsDNA spiked in mouse plasma. The LOD was calculated to be 0.86 pM with a wide linear range of 1 pM to 50 µM. To the best of our knowledge, this is the first report on using PNA to detect ds-methylated DNA. This sandwich design can be modified to detect other methylated genes, making it a promising platform to detect ds-methylated biomarkers.

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Section: Resultsmentioning

confidence: 99%

Detection of a Double-Stranded MGMT Gene Using Electrochemically Reduced Graphene Oxide (ErGO) Electrodes Decorated with AuNPs and Peptide Nucleic Acids (PNA)

Safarzadeh

Pan

2022

Biosensors

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“…Поверхность электродов модифицируют гидроталькитом [158], углеродными нанотрубками [155], наночастицами металлов [156,157], полимерными [152,163,164], гибридными [159,160] материалами или иммобилизируют различными ферментами (например, лизиноксилаза и тирозин) с применением кросс-сшивки ферментного слоя глутаровым альдегидом [148,149,151].…”

Section: электрохимические методы определенияunclassified

Benzoic and Salicylic acids concentration and determination in food and water mediums

Sukhanov¹,

Savvina²,

Кушнир³

et al. 2018

АиК

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Приведен обзор литературы по современным методам пробоподготовки и определения бензойной (БК) и салициловой кислот (СК) в различных водных средах и продуктах питания. Обсуждается применение органо-неорганических полимерных композиционных материалов на основе глин (бентонит, монтмориллонит, вермикулиты), коммерческих гранулированных активных углей, биоуглей, полимерных сорбентов природного и синтетического происхождения для концентрирования БК и СК из водных сред, в том числе из сточных вод и почвенных растворов. Описаны схемы получения и модифицирования сорбентов поверхностно-активными веществами, наночастицами и катионами металлов. Приведены значения предельной сорбции, уровни концентраций сорбируемых соединений, время достижения сорбционного равновесия, а также способы определения в концентратах сорбатов. Изложены способы выделения, изолирования, концентрирования или экстракции БК и СК из продуктов питания (алкогольные и безалкогольные напитки, молоко и молочные продукты, сиропы, крупы, овощи, фрукты и т.д.). Для определения БК и СК в различных объектах рекомендуются хроматографические (высокоэффективная жидкостная, ионная, газовая, тонкослойная хроматография), электрохимические, спектрометрические методы анализа и капиллярный электрофорез. Приведены условия детектирования аналитов, применяемые подвижные и неподвижные фазы, условия элюирования, составы фоновых растворов, характеристики электрохимического определения, а также пределы обнаружения в различных матрицах, содержащих БК и СК. Ключевые слова: бензойная кислота, салициловая кислота, концентрирование, определение, пищевые продукты, водные среды.

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“…Owing to these unique features, several attempts have been made to prepare different REMs including GdHCF [7], NdHCF [8], EuHCF [9], HoHCF [4], ErHCF [10], and YbHCF [11]. In our group, we have prepared several MHCFs such as DyHCF, NdHCF, YHCF, LuHCF and SmHCF [12][13][14][15][16] to fabricate modified electrodes that have great potential in electrochemical sensor applications. In a recent report, Cerium hexacyanoferrate (CeHCF) has been prepared and studied in detail [3].…”

Section: Introductionmentioning

confidence: 99%

An electrochemical approach: Switching Structures of rare earth metal Praseodymium hexacyanoferrate and its application to sulfite sensor in Red Wine

Devadas

Sivakumar

Chen

et al. 2015

Electrochimica Acta

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Controlled electrochemical synthesis of new rare earth metal lutetium hexacyanoferrate on reduced graphene oxide and its application as a salicylic acid sensor

Abstract: A controlled electrochemical synthesis of new rare earth metal lutetium hexacyanoferrate on reduced graphene oxide and its application as a salicylic acid sensor.

Cited by 15 publications

References 60 publications

Detection of a Double-Stranded MGMT Gene Using Electrochemically Reduced Graphene Oxide (ErGO) Electrodes Decorated with AuNPs and Peptide Nucleic Acids (PNA)

Detection of a Double-Stranded MGMT Gene Using Electrochemically Reduced Graphene Oxide (ErGO) Electrodes Decorated with AuNPs and Peptide Nucleic Acids (PNA)

Benzoic and Salicylic acids concentration and determination in food and water mediums

An electrochemical approach: Switching Structures of rare earth metal Praseodymium hexacyanoferrate and its application to sulfite sensor in Red Wine

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