Controlled drug release from coated floating ion exchange resin beads

Atyabi, Fatemeh; Sharma, H.L.; Mohammad, Hussain; Fell, John T.

doi:10.1016/0168-3659(96)01343-0

Cited by 76 publications

(31 citation statements)

References 6 publications

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“…Shishu et al (2007a) developed a FDDS using gasforming agents, like sodium bicarbonate, citric acid, and hydrocolloids, like hydroxypropyl methylcellulose (HPMC) and Carbopol 934P. The results of the in vitro release studies showed that the optimized formulation could sustain drug release for 24 h and remain buoyant for 16 h. Nakagawa et al (2006) developed a novel intra-gastric FDDS by pulsed plasma-irradiation on the doublecompressed tablet of 5-Fluorouracil as a core material with outer layer composed of a 68/17/15 weight ratio of Povidone, Eudragit RL, and sodium bicarbonate, and the result showed that the release of 5-Fluorouracil from the tablet was sustained by occurrence of a plasma-induced cross-link reaction on the outer layer of the tablet Atyabi et al (1996) prepared ion exchange resin beads loaded with bicarbonate and coated with a semipermeable membrane. These prepared beads exhibit prolonged gastric residence due to the release of carbon dioxide which is trapped inside the coating of the beads.…”

Section: Effervescent Systemsmentioning

confidence: 99%

Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems

et al. 2010

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Section: Effervescent Systemsmentioning

confidence: 99%

Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems

et al. 2010

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“…The drug release from the uncoated resinate was rapid and complete in 2.5 hours. Although drug release from Dowex 2 Â 10 resin has been reported to be slower in SGF than in SIF because of the larger size of the exchanging phosphate anion and the lower affinity of the functional groups of the resin for phosphate, 22 in the present study the drug release from the Indion 254 resin-drug complex was found to be independent of pH. The release of drug from the microcapsules was slower than that from the uncoated resinate, and the retardation of drug release was influenced by the formulation parameters.…”

Section: Drug Release From Microcapsulesmentioning

confidence: 99%

Preparation and in vitro evaluation of polystyrene-coated diltiazem-resin complex by oil-in-water emulsion solvent evaporation method

Halder

2006

AAPS PharmSciTech

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The purpose of this study was to examine the suitability of polystyrene-coated (PS-coated) microcapsules of drug-resin complex for achieving prolonged release of diltiazem-HCl, a highly water-soluble drug, in simulated gastric and intestinal fluid. The drug was bound to Indion 254, a cation-exchange resin, and the resulting resinate was microencapsulated with PS using an oil-in-water emulsion-solvent evaporation method. The effect of various formulation parameters on the characteristics of the microcapsules was studied. Mean diameter and encapsulation efficiency of the microcapsules rose with an increase in the concentration of emulsion stabilizer and the coat/core ratio, while the same characteristics tended to decrease with an increase in the volume of the organic disperse phase. The desorption of drug from the uncoated resinate was quite rapid and independent of the pH of the dissolution media. On the other hand, the drug release from the microcapsules was prolonged for different periods of time depending on the formulation parameters and was also found to be independent of the pH of the dissolution media. Both the encapsulation efficiency and the retardation of drug release were found to be dependent on the uniformity of coating, which in turn was influenced by the formulation parameters. Kinetic studies revealed that the desorption of drug from the resinate obeyed the typical particle diffusion process, whereas the drug release from the microencapsulated resinate followed the diffusioncontrolled model in accordance with the Higuchi equation. PS appeared to be a suitable polymer to provide prolonged release of diltiazem independent of the pH of the dissolution media.

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“…In a study by Atyabi et al, microparticles loaded with theophylline and bicarbonate were prepared (Atyabi et al, 1996a). The ion-exchange resin beads (Amberlite IRA-400 ® and Dowex 2X10 ® ) were coated with a semi-permeable membrane (Eudragit RS).…”

Section: Floating Microparticlesmentioning

confidence: 99%

Gastroretentive microparticles for drug delivery applications

Adebisi

Conway

2011

Journal of Microencapsulation

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Many strategies have been proposed to explore the possibility of exploiting gastroretention for drug delivery. Such systems would be useful for local delivery, for drugs that are poorly soluble at higher pH or primarily absorbed from the proximal small intestine. Generally, the requirements of such strategies are that the vehicle maintains controlled drug release and exhibits prolonged residence time in the stomach. Despite widespread reporting of technologies, many have an inherent drawback of variability in transit times. Microparticulate systems, capable of distributing widely through the GI tract, can potentially minimize this variation. While being retained in the stomach, the drug content is released slowly at a desired rate,

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Controlled drug release from coated floating ion exchange resin beads

Cited by 76 publications

References 6 publications

Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems

Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems

Preparation and in vitro evaluation of polystyrene-coated diltiazem-resin complex by oil-in-water emulsion solvent evaporation method

Gastroretentive microparticles for drug delivery applications

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