Controlled drug release characteristics and antibacterial influence of streptomycin sulfate-loaded PMMA/PEO/bis-chalcone derivatives-based fibers

Maşlakcı, Neslihan Nohut; Eren, Esin; Kocer, Kadinsah Nur; Cevikbas, Halime; Ulusoy, Seyhan; Biçer, Abdullah; Cin, Günseli Turgut; Öksüz, Ayşegül Uygun

doi:10.1016/j.mtcomm.2022.103784

Cited by 2 publications

(4 citation statements)

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“…Regarding FTIR of CD, the O–H stretching vibrational modes corresponding to distinct −OH groups (primary and secondary groups) and HOH are detected in the 3500–3000 cm –1 range and the C–H stretching bands appeared at 2921 cm –1 . In the literature, the STP’s typical peaks are 2352 and 2364 cm –1 due to C–O, CC stretching, and 1969 cm –1 due to −OH stretching . Infrared investigations revealed that the −CO, −OH, and −NH groups make up the majority of STP functional group assignments.…”

Section: Results and Discussionmentioning

confidence: 93%

“…Notably, the controlled release of STP at pH 7.4 (8.5 μg/mL) over 260 min closely resembled the release profile observed at pH 5.5 (5.5 μg/mL). It is essential to acknowledge that the soluble nature of CHN at lower pH values contributed to the favorable CHN-released profile at pH 5.5. , The accelerated release (%) observed in PVA/CHN/β-CD@STP can be attributed to its more concentrated polymeric chain, featuring porous structures, smaller fiber diameter, and shorter distances that facilitate rapid diffusion of STP, thereby expediting its release. ,, …”

Section: Results and Discussionmentioning

confidence: 99%

“… 46 In the literature, the STP’s typical peaks are 2352 and 2364 cm –1 due to C–O, C=C stretching, and 1969 cm –1 due to −OH stretching. 47 Infrared investigations revealed that the −C=O, −OH, and −NH groups make up the majority of STP functional group assignments. These functional groups overlapped with the nanofibers polymers and may be attributed to the total encapsulation of STP into the polymer’s matrix.…”

Section: Results and Discussionmentioning

confidence: 99%

“…54,55 The accelerated release (%) observed in PVA/CHN/β-CD@STP can be attributed to its more concentrated polymeric chain, featuring porous structures, smaller fiber diameter, and shorter distances that facilitate rapid diffusion of STP, thereby expediting its release. 37,47,56 3.5. Cytocompatibility.…”

Section: In Vitro Detection Of Drug Loading and Release Studymentioning

confidence: 99%

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Synthesis of Cross-Linked and Sterilized Water-Soluble Electrospun Nanofiber Biomatrix of Streptomycin-Imbedded PVA/CHN/β-CD for Wound Healing

Mohsen,

Abdel Gaber,

Shoueir

et al. 2024

ACS Omega

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The diagnosis and prognosis of chronic wounds are demanding and require objective assessment. Because of their potential medicinal applications, the syntheses of biopolymeric chitosan (CHN) structure and PVA-based mixed electrospun nanofibers with biomimetic features were thoroughly investigated. This study created different formulas, including a guest molecule and capping agent, using supporting PVA as a vehicle. CHN was used as a biomodifier, and beta-cyclodextrin (ß-CD) as a smoother and more efficiently entraps streptomycin (STP) compared with the silver sheet wound dressing. The relevant analyses showed that the size distribution increased with the incorporation of PVA, CHN, and ß-CD to 120.3, 161.9, and 192.02 nm. The webs boosted particle size and released content stability to 96.4% without compromising the nanofiber structure. Examining the synergistic effects of the PVA/CHN/STP/ß-CD nanoformulation against pathogenic strains of S. aureus, P. aeruginosa, and Aspergillus niger, clean zones were 47 ± 3.4, 45 ± 3.0, and 49 ± 3.7 mm were produced. PVA/CHN/STP/ß-CD formula exhibited a 98.9 ± 0.6% cell viability and wound closure of 100% at 72 h. The results reveal that the PVA/CHN/STP/ß-CD formula is promising for medical applications, especially in wound healing, compared with the silver sheet.

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Section: Results and Discussionmentioning

confidence: 93%