Controlled Drug Release by the Pore Structure in Polydimethylsiloxane Transdermal Patches

Mikolaszek, Barbara; Kazlauske, Jurgita; Larsson, Anette; Sznitowska, Małgorzata

doi:10.3390/polym12071520

Cited by 15 publications

(12 citation statements)

References 29 publications

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“…Applying a single-layer material to a metal surface forms a membrane with excellent waterproofing properties that comprehensively protects against the harmful effects of weather conditions. Therefore, one can conclude that a carefully selected hydrophilic materials can provide such properties [ 2 , 3 ]. Silicone coatings are resistant to discoloration, so they are often used to protect many kinds of external surfaces against the effects of ultraviolet radiation and does not actuate by electrical stimulation [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Zinc Waste Filler on the Tribological and Mechanical Properties of Silicone-Based Composites

et al. 2021

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Silicones are often used for various types of coatings, but due to their poor mechanical properties, they often require modification to meet specific requirements. At the same time, various production processes throughout the world generate different types of waste, the disposal of which is harmful to the environment. One possible solution is to use production waste as a filler. In this paper, the authors investigated how the use of metallurgical production waste products as fillers changed the mechanical properties of silicone composites prepared by casting. Composite samples were characterized using tensile tests, resilience, pin-on-disc, Schopper–Schlobach abrasion, hardness, and density measurements. Based on the obtained results, the authors assessed the effect of each of the fillers used in different weight proportions. The results showed that the silicone composite filled with 5 wt% zinc dust showed the lowest decrease in tensile strength and Young’s modulus, with a simultaneous significant reduction in abrasion compared with the reference sample. This research shows that zinc waste can be successfully introduced into a silicone matrix in cases where it is important to reduce abrasive wear.

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Section: Introductionmentioning

confidence: 99%

The Influence of Zinc Waste Filler on the Tribological and Mechanical Properties of Silicone-Based Composites

et al. 2021

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“…Prepared patches have a highly porous morphology ( Figure 5 , Figure 6 and Figure 7 ) and hydrophilic groups in their structure thanks to their modification with amino acids ( Figure 2 ). In general, it is known that hydrogels are superior to other polymeric materials in diffusion-controlled drug delivery systems [ 17 , 25 , 26 , 27 , 30 , 37 , 39 , 40 ]. They have a great affinity to aquatic solution.…”

Section: Resultsmentioning

confidence: 99%

“…The term hydrogel in this case refers to the 3D, highly porous structure which can be swollen with aquatic medium. 27,30,37,39,40]. They have a great affinity to aquatic solution.…”

Section: Swelling Abilities Studymentioning

confidence: 99%

Development of Stimuli-Responsive Chitosan/ZnO NPs Transdermal Systems for Controlled Cannabidiol Delivery

et al. 2021

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One of the most common neurological diseases is epilepsy, which not only negatively affects the quality of people’s life but also may lead to life-threatening situations when its symptoms such as seizures cannot be controlled medically. A very serious problem to be overcame is the untreatable form of this disease, which cannot be cured by any currently available medicines. Cannabidiol, which is a natural product obtained from Cannabis Sativa, brings a new hope to people suffering from drug-resistant epilepsy. However, the hydrophobic character of this compound significantly lowers its clinical efficiency. One of the promising methods of this substance bioactivity increase is delivery through the skin tissue. In this article, a new type of advanced transdermal systems based on chitosan and ZnO nanoparticles (NPs) has been developed according to Sustained Development principles. The chemical modification of the biopolymer confirmed by FT-IR method resulted in the preparation of the material with great swelling abilities and appropriate water vapor permeability. Obtained nanoparticles were investigated over their crystalline structure and morphology and their positive impact on drug loading capacity and cannabidiol controlled release was proved. The novel biomaterials were confirmed to have conductive properties and not be cytotoxic to L929 mouse fibroblasts.

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“…This could result in an engineered release system allowing drug application over a predetermined time. [ 48,49 ]…”

Section: Discussionmentioning

confidence: 99%

Self‐Adhesive Silicone Microstructures for the Treatment of Tympanic Membrane Perforations

Lana

Sorg

Wenzel

et al. 2021

Advanced NanoBiomed Research

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Inspired by the gecko foot, polymeric microstructures have demonstrated reliable dry adhesion to both stiff objects and sensitive surfaces such as skin. Microstructured silicone patches are proposed, herein, for the treatment of tympanic membrane perforations with the aim of serving as an alternative for current surgical procedures that require anesthesia and ear canal packing. Sylgard 184 PDMS micropillars of 20 μm in diameter and 60 μm in length are topped by a Soft Skin Adhesive (SSA) MG7‐1010 terminal layer, of about 25 μm thickness. The adhesion is evaluated by specially designed tack tests against explanted murine eardrums and, for comparison, against a rigid substrate. Functional effects are evaluated using auditory brainstem responses (ABRs) and distortion product otoacoustic emissions (DPOAE). The adhesion strength of the microstructure and unstructured controls to explanted murine tympanic membranes is comparable (typically 12 kPa), but the microstructured patches are easier to handle by the surgeon. For the first time, partial recovery of hearing performance is measured immediately after patch application. The novel patches adhere without the need for further fixation, removing the need for ear canal packing. The proposed material design holds great promise for improving clinical treatments of tympanic membrane perforations.

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Controlled Drug Release by the Pore Structure in Polydimethylsiloxane Transdermal Patches

Cited by 15 publications

References 29 publications

The Influence of Zinc Waste Filler on the Tribological and Mechanical Properties of Silicone-Based Composites

The Influence of Zinc Waste Filler on the Tribological and Mechanical Properties of Silicone-Based Composites

Development of Stimuli-Responsive Chitosan/ZnO NPs Transdermal Systems for Controlled Cannabidiol Delivery

Self‐Adhesive Silicone Microstructures for the Treatment of Tympanic Membrane Perforations

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