Controlled Drug Release and Antibacterial Properties of Levofloxacin-Loaded Silk/Chitosan Green Composite for Wound Dressing

Suhail, Zarmeen; Shoukat, Hifza; Sanbhal, Noor; Chowdhry, Narinder P.; Bhutto, Muhammad Aqeel; Soomro, Suhail Ahmed; Ansari, Abdul Qadir; Memon, None Rashid Hussain

doi:10.1007/s44174-022-00048-7

Cited by 4 publications

(5 citation statements)

References 30 publications

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“…Suhail et al, reported antibacterial properties of silk/chitosan green composite for wound dressing. The author mentioned that as the amount of chitosan increased the inhibition zone decreased [45]. We observed results in same trend as the amount of chitosan decreased the inhibition zone increased.…”

Section: Antibacterial Activitysupporting

confidence: 77%

“…Hemp fiber-based products, such as powders, hemp textiles, and extracts, can be employed as the latest form of natural antibacterial material [35] Secondly, the physical application of antibiotics is a far better choice to reduce the infection of the wound without any side effects on the body. The work has been done on different composites, such as silk/chitosan [36] or cyclodextrin [37] based composites. Many biomedical textile materials have been utilized for biomedical devices such as hernia mesh devices, stents [38,39] and composites [40,41].…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial activity of cellulose/chitosan green composite for wound healing

Sanbhal,

Solangi,

Memon

et al. 2023

Mehran Univ. res. j. eng. technol.

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Cellulosic antibacterial fibers have great importance in the manufacturing of healthcare products. In this research work, antibacterial hemp and bamboo fibers were selected for manufacturing two green composite for wound healing. The chitosan was selected to get gel formation and behave as carrier in the manufacturing of cellulosic/chitosan green composite. Moreover, a water-soluble levofloxacin was included to give a release of antibacterial properties. The hemp and bamboo fibers were cleaned and fiber-to-fiber separation was done with a manual comber machine. The chitosan was solubilized using acetic acid and stirred for 12 hours to get a completely clear and viscous gel. Afterward, powder ground hemp and bamboo fibers were separately poured into two separate beakers. Two different types of composites (hemp/chitosan) and Bamboo/chitosan were transferred into petri dishes and dried in the oven at 400C for 24 hours. The samples were loaded with a levofloxacin antimicrobial agent. Both composites (hemp/chitosan, and bamboo/chitosan) were characterized for surface morphology, structural changes and antimicrobial testing against gram-positive and gram-negative bacteria. It was analyzed that without levofloxacin both cellulose/chitosan composites resisted bacteria growth and did not show inhibition zone, but samples loaded with levofloxacin displayed good antibacterial activity and showed excellent zone of inhibition against gram-positive and gram-negative bacteria. Futhermore, FTIR evidenced that there was no formation of cross linking composites, but composites were held together due to chitosan and fibers gel formation.

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Section: Antibacterial Activitysupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of cellulose/chitosan green composite for wound healing

Sanbhal,

Solangi,

Memon

et al. 2023

Mehran Univ. res. j. eng. technol.

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“…Inverted phase contrast and fluorescence microscopy were used to watch and photograph the cell movement and regeneration. We measured initial injury and cell movement in the scratched region using Image J at 24-, 48-, and 72-h. We measured the overall quantity of cell migration three times to ensure accuracy [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

“…In addition, levofloxacin-induced pregnane X receptor stimulation has been linked to accelerated wound healing. In addition, the drug was effectively used for oral therapy of diabetic foot osteomyelitis [ 36 ]. Levofloxacin incorporated ZIF-8-based nanoparticles for abdominal surgery after wound healing, which was the present study's primary topic.…”

Section: Introductionmentioning

confidence: 99%

Design and development of pH-responsive levofloxacin-loaded metal-organic framework for the promising treatment of pediatric abdominal wound repair

Wang,

Li,

Shao

et al. 2024

Regenerative Therapy

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“…Levofloxacin, classified as a fluoroquinolone antibiotic, exhibits broad-spectrum activity against various bacterial pathogens. Levofloxacin is also approved by the FDA for the treatment of several medical conditions and has been used in wound dressings as a therapeutic approach to the treatment of infected wounds, highlighting its potential role in the healing of infected wounds [ 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Development of an In Situ Photo-Crosslinking Antimicrobial Collagen Hydrogel for the Treatment of Infected Wounds

Wu,

Tsai

2023

Polymers

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Antimicrobial hydrogels have received considerable attention in the treatment of bacteria-infected wounds. Herein, we develop a neutral, soluble collagen via modification with maleic anhydride, serving as a hydrogel precursor. Maleic anhydride-modified collagen (ColME) could form a gel after exposure to UV light and be loaded with the antimicrobial agents, nisin and levofloxacin, to acquire antimicrobial ability. The ColME hydrogel containing nisin and levofloxacin had good cytocompatibility and effectively killed pathogenic bacterial strains, such as Escherichia coli and Staphylococcus aureus. The antimicrobial ColME hydrogels effectively supported the healing of a full-thickness skin wound infected with S. aureus in a mouse model. Our results demonstrate the potential of antimicrobial hydrogels as effective wound dressings via in situ photogelation for the healing of infected wounds.

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Controlled Drug Release and Antibacterial Properties of Levofloxacin-Loaded Silk/Chitosan Green Composite for Wound Dressing

Cited by 4 publications

References 30 publications

Antibacterial activity of cellulose/chitosan green composite for wound healing

Antibacterial activity of cellulose/chitosan green composite for wound healing

Design and development of pH-responsive levofloxacin-loaded metal-organic framework for the promising treatment of pediatric abdominal wound repair

Development of an In Situ Photo-Crosslinking Antimicrobial Collagen Hydrogel for the Treatment of Infected Wounds

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