Controlled drug delivery from porous hydroxyapatite grafts: An experimental and theoretical approach

Palazzo, Barbara; Sidoti, M. C.; Roveri, Norberto; Tampieri, Anna; Sandri, Monica; Bertolazzi, L.; Galbusera, Fabio; Dubini, Gabriele; Vena, Pasquale; Contro, R.

doi:10.1016/j.msec.2005.01.011

Cited by 82 publications

(39 citation statements)

References 17 publications

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“…As already pointed out, [27][28][29] the adsorption and release of bioactive molecules are strongly affected not only by the chemical properties of the drug molecule but also by the chemical and structural characteristics of the HA substrates. Thus, in this paper we have investigated the adsorption and release of cisplatin (Fig.…”

Section: Introductionmentioning

confidence: 91%

Biomimetic Hydroxyapatite–Drug Nanocrystals as Potential Bone Substitutes with Antitumor Drug Delivery Properties

Palazzo

Iafisco

Laforgia

et al. 2007

Adv Funct Materials

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326

234

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This Full Paper investigates the adsorption and desorption of the anticancer drugs cis‐diamminedichloroplatinum(II) (CDDP, cisplatin) and the new platinum(II) complex di(ethylenediamineplatinum)medronate (DPM), as well as the clinically relevant bisphosphonate alendronate, towards two biomimetic synthetic HA nanocrystalline materials with either plate‐shaped (HAps) or needle‐shaped (HAns) morphologies and different chemico‐physical properties. The adsorption and desorption kinetics are dependent on the specific properties of the drugs and the morphology of the HA nanoparticles. Adsorption of the platinum complexes occurs with retention of the nitrogen ligands but the chloride ligands of cisplatin are displaced. Despite their opposite charges, the negatively charged alendronate bisphosphonate and the positively charged aquated cisplatin are strongly adsorbed, while the neutral DPM complex shows lower affinity towards the negatively charged apatitic surface. The data suggest that adsorption of the two platinum complexes is driven by electrostatic attractions, while interaction between the alendronate and the HA surface takes place by ligand exchange in which the two phosphonate groups of the drug molecule replace two surface phosphate groups. Significantly, adsorption of positively charged hydrolysis species of cisplatin is more favored on the phosphate‐rich HAns surface while adsorption of negatively charged alendronate is more favored on the calcium‐rich HAps surface. The latter type of short‐range electrostatic interactions also appear to dominate the desorption kinetics; consequently, drug release is greater for neutral DPM than for charged alendronate and aquated cisplatin. Moreover, while the release per unit area of charged species is the same for the two types of HAs, the release of DPM is faster from HAns, which is lower in surface calcium, than for HAps. Overall, this work demonstrates that the properties of HA nanocrystals can be modulated in such a way to produce HA/biomolecule conjugates tailored for specific therapeutic applications.

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Section: Introductionmentioning

confidence: 91%

Biomimetic Hydroxyapatite–Drug Nanocrystals as Potential Bone Substitutes with Antitumor Drug Delivery Properties

Palazzo

Iafisco

Laforgia

et al. 2007

Adv Funct Materials

Self Cite

326

234

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“…Several groups have designed different types of porous calcium phosphates for drug delivery accordingly. Palazzo et al [21] tested their porous HA device with a bimodal porosity degree (60% and 40%) as controlled drug delivery devices for antiinflammatory drugs. Another device with a bimodal porosity have been introduced for a controlled delivery of an anti-phlogistic, hydrocortisone acetate [29].…”

Section: Applications Of Porous Hamentioning

confidence: 99%

Porous hydroxyapatite for artificial bone applications

Sopyan

Mel

Ramesh

et al. 2007

Science and Technology of Advanced Materials

362

164

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Hydroxyapatite (HA) has been used clinically for many years. It has good biocompatibility in bone contact as its chemical composition is similar to that of bone material. Porous HA ceramics have found enormous use in biomedical applications including bone tissue regeneration, cell proliferation, and drug delivery. In bone tissue engineering it has been applied as filling material for bone defects and augmentation, artificial bone graft material, and prosthesis revision surgery. Its high surface area leads to excellent osteoconductivity and resorbability providing fast bone ingrowth. Porous HA can be produced by a number of methods including conversion of natural bones, ceramic foaming technique, polymeric sponge method, gel casting of foams, starch consolidation, microwave processing, slip casting, and electrophoretic deposition technique. Some of these methods have been combined to fabricate porous HA with improved properties. These combination methods have yielded some promising results. This paper discusses briefly fundamental aspects of porous HA for artificial bone applications as well as various techniques used to prepare porous HA. Some of our recent results on development of porous HA will be presented as well. r

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“…Many studies have demonstrated that HA ceramics can be used to deliver steroids, antibiotics, proteins, hormones, anticancer drugs. Porous ceramics closely mimicking spongy bone morphology have been synthesized by impregnation of cellulosic sponges with poorly crystalline HA water suspension ( Figure 5) (Palazzo et al, 2005). These porous ceramics have been tested as controlled drug delivery bone grafts to evaluate the fundamental parameters that control release kinetics.…”

Section: Preparation Of Biomimetic Hydroxyapatitesmentioning

confidence: 99%

The Biomimetic Approach to Design Apatites for Nanobiotechnological Applications

Roveri¹,

Iafisco²

2011

Advances in Biomimetics

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Controlled drug delivery from porous hydroxyapatite grafts: An experimental and theoretical approach

Cited by 82 publications

References 17 publications

Biomimetic Hydroxyapatite–Drug Nanocrystals as Potential Bone Substitutes with Antitumor Drug Delivery Properties

Biomimetic Hydroxyapatite–Drug Nanocrystals as Potential Bone Substitutes with Antitumor Drug Delivery Properties

Porous hydroxyapatite for artificial bone applications

The Biomimetic Approach to Design Apatites for Nanobiotechnological Applications

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