Controlled dose confirmation study of a 2% moxidectin equine gel against equine internal parasites in The Netherlands

Eysker, M.; Boersema, J.H.; Grinwis, Guy C. M.; Kooyman, F.N.J.; Poot, Jacqueline

doi:10.1016/s0304-4017(96)01135-1

Cited by 23 publications

(16 citation statements)

References 7 publications

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“…2006). It should be noted, however, that variable efficacy of MOX against EL3 has been reported in the literature; for example Eysker et al . (1997) and Xiao et al .…”

Section: Anthelminticsmentioning

confidence: 99%

An update on cyathostomins: Anthelmintic resistance and diagnostic tools

Stratford

McGorum

Pickles

et al. 2011

Equine Veterinary Journal

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SummaryCyathostomins represent a potential cause of equine morbidity and have become the main focus of endoparasite control in managed horses. All grazing horses are at risk of infection with cyathostomins; therefore, the application of appropriate management measures is essential. Anthelmintics currently comprise the main method of control for equine nematodes and the ready availability of these products in some countries has resulted in their use becoming dissociated from veterinary involvement. This is concerning given the levels of anthelmintic resistance that have been recorded in cyathostomin populations. It is important that veterinarians re-establish control over the implementation of parasite control programmes, a major objective of which should be the preservation of anthelmintic efficacy. This article details the principles of cyathostomin control in horses with particular reference to anthelmintic resistance, and the use and interpretation of diagnostic tests for detecting cyathostomins and identifying anthelmintic resistance.

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“…2006). It should be noted, however, that variable efficacy of MOX against EL3 has been reported in the literature; for example Eysker et al . (1997) and Xiao et al .…”

Section: Anthelminticsmentioning

confidence: 99%

An update on cyathostomins: Anthelmintic resistance and diagnostic tools

Stratford

McGorum

Pickles

et al. 2011

Equine Veterinary Journal

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“…(1995) demonstrated that ivermectin had an efficacy of 77% against developing larvae and, in the same study, no EL3 could be recovered by digestion. Recent studies have shown that moxidectin is consistently active against developing cyathostome larvae; against EL3 results vary from ineffective to a good efficacy (Xiao et al., 1994; Monahan et al., 1996; Eysker et al., 1997). The protocols for all these studies have been variable.…”

Section: Introductionmentioning

confidence: 99%

Treatment and Follow‐Up of Clinical Cyathostominosis in Horses*

Deprez¹,

Vercruysse

2003

Journal of Veterinary Medicine Series A

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The results of the treatment with moxidectin or ivermectin of 20 horses with clinical cyathostominosis were studied during a 3-week observation period. Both treatments were effective in completely eliminating larvae from the faeces within 1 or 2 weeks, but no significant improvement in body weight or clinical parameters could be demonstrated over the observation period. The poor short time results of the treatment support the need for an adequate prevention of cyathostominosis in horses.

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“…However, one major difference is that MOX is licensed for high efficacy (for example, 90.8%) against EL3 at a single dose (Bairden et al 2001). It should be noted, however, that these data were in contrast to earlier results that suggested a lower efficacy of MOX against these stages (Xiao et al 1994;Eysker et al 1997). The differences between these studies have never been entirely resolved, but may be due to variation in time scale that the horses were necropsied after MOX treatment.…”

Section: Macrocyclic Lactone Resistancementioning

confidence: 86%

An update on cyathostomins: Anthelmintic resistance and worm control

Matthews

2008

Equine Veterinary Education

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Summary Intestinal nematodes are an important cause of equine disease. Of these parasites, the Cyathostominae are the most important group, both in terms of their prevalence and their pathogenicity. Cyathostomin infections are complex and control is further complicated by ever‐increasing levels of resistance to some of the commonly used anthelmintics. There are no new equine anthelmintics under development, so it is imperative that the efficacy of any currently‐effective drug classes be maintained for as long as possible. It is believed that the proportion of refugia (i.e. the percentage of parasites not exposed to a drug at each treatment) is one of the most crucial factors in determining the rate at which anthelmintic resistance develops. It is important, therefore, that levels of refugia be taken into account when designing nematode control programmes for horses. This can be assisted by knowledge of the local epidemiology of the infection, supplemented by faecal egg count analysis to identify those animals that are making the major contribution to pasture contamination. This type of rational nematode control requires equine veterinary surgeons to get involved in designing and implementing deworming programmes. The advice given must be based on a combination of knowledge of cyathostomin biology and epidemiology as well as an awareness of the parasite population's current drug sensitivity and a sound history of husbandry at the establishment. As anthelmintic resistance will be the major constraint on the future control of cyathostomins, researchers are now actively investigating this area. Studies are underway to develop tests that will enable earlier detection of anthelmintic resistance and an assay that will help identify those horses that require anthelmintic treatments targeted at intestinal wall larvae.

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Controlled dose confirmation study of a 2% moxidectin equine gel against equine internal parasites in The Netherlands

Cited by 23 publications

References 7 publications

An update on cyathostomins: Anthelmintic resistance and diagnostic tools

An update on cyathostomins: Anthelmintic resistance and diagnostic tools

Treatment and Follow‐Up of Clinical Cyathostominosis in Horses*

An update on cyathostomins: Anthelmintic resistance and worm control

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