Controlled depth of needling using simple injection needles

AlJasser, Mohammed I.; Altalhab, Saad

doi:10.1016/j.jaad.2020.02.068

Cited by 2 publications

(7 citation statements)

References 2 publications

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“…Pain 14, erythema (13) Not satisfied (4), slight satisfied (6), satisfied (7), very satisfied (8) Giorgio et al Note: 5 grade scale*: G0: no repigmentation, poor response; G1: up to 25% repigmentation, satisfactory response; G2: 25% to 50% repigmentation, good response; G3: 50% to 75% repigmentation, very good response; and G4: >75% repigmentation, excellent response. Abbreviations: 5FU, 5 fluorouracil; acral, hands and feet; CR, clinical response; IGA, investigator's global assessment; NB-UVB, narrowband ultraviolet B; PDT, photodynamic therapy; PGA: Physician's Global Assessment; TCA, trichloroacetic acid.…”

Section: Microneedling With Latanoprost and Nb-uvbmentioning

confidence: 99%

“…8,9 Microneedling is better than simple injection needle in controlling depth of penetration and thus preventing excessive pain during injection. 8 It causes a microinflammation in the epidermal layer, which enhances melanocytes and keratinocytes migration and stimulates repigmentation of vitiligo areas. 10 Additionally, it provides successful melanocytes grafting from pigmented to unpigmented areas and enhances the penetration of topical agents into the skin.…”

Section: Introductionmentioning

confidence: 99%

“…A recent approach using needling showed favorable degrees of repigmentation 7 . It can be done using simple injection needles or microneedling devices such as: manual roller, dermarollers, automated needle pen devices, and microneedling fractional radiofrequency devices 8,9 . Microneedling is better than simple injection needle in controlling depth of penetration and thus preventing excessive pain during injection 8 .…”

Section: Introductionmentioning

confidence: 99%

“…It can be done using simple injection needles or microneedling devices such as: manual roller, dermarollers, automated needle pen devices, and microneedling fractional radiofrequency devices 8,9 . Microneedling is better than simple injection needle in controlling depth of penetration and thus preventing excessive pain during injection 8 . It causes a microinflammation in the epidermal layer, which enhances melanocytes and keratinocytes migration and stimulates repigmentation of vitiligo areas 10 .…”

Section: Introductionmentioning

confidence: 99%

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Microneedling in vitiligo: A systematic review

Salloum

Bazzi

Maalouf

et al. 2020

Dermatologic Therapy

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Microneedling was initially introduced for skin rejuvenation; however, this minimally invasive procedure is now being used for the treatment of multiple dermatological conditions. Recent reports have shown its efficacy in the treatment of vitiligo. This review analyzes the current literature on microneedling techniques, efficacy, and safety for vitiligo treatment. An extensive PubMed was done to identify the literature on microneedling treatment for vitiligo. Case reports, case series, and clinical trials were included in this review. All 14 articles evaluated showed improvement of vitiligo lesions after microneedling treatment. The combination of microneedling and topical tacrolimus, 5-fluorouracil, topical calcipotriol and betamethasone, narrowband ultraviolet B with or without photodynamic therapy, and triamcinolone acetonide solution yielded more efficacy than microneedling monotherapy. Microneedling is a safe and efficient technique in the treatment of vitiligo. Thus, it can be an alternative treatment for vitiligo especially when the latter is resistant to conventional therapies.

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Section: Microneedling With Latanoprost and Nb-uvbmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Microneedling in vitiligo: A systematic review

Salloum

Bazzi

Maalouf

et al. 2020

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

“…The recent use of needles has shown favorable degrees of repigmentation [8] and this physical trauma can be done using simple injection needles or microneedling devices like dermaroller, automated dermapen and microneedling radiofrequency devices. Microneedling is superior to simple injection needles as it controls the depth of penetration and maintains uniformity and also reduces the pain during injection [9]. It produces micro-inflammation in the epidermal layers, which stimulates and enhances the melanocytes and keratinocytes to migrate and help in vitiligo repigmentation [10].…”

mentioning

confidence: 99%

A single blind active controlled study to compare the efficacy of microneedling and microneedling with 5-flurouracil in treatment of stable vitiligo

Jartarkar¹,

Manjunath²,

Harini³

et al. 2021

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Introduction: Microneedling, a tool for transdermal delivery of drugs, improves the skin permeability to various therapeutic agents. 5-fluorouracil is a chemotherapeutic agent, a pyrimidine analogue, used in various combination chemotherapy regimens. It has been noticed that following topical 5-fluorouracil cream application, patients developed localized hyperpigmentation and this has gained the attention towards use of 5-fluorouracil in repigmentation of vitiliginous patches. Objective: To assess the effectiveness of topical 5-fluorouracil following microneedling and to compare its results with microneedling alone in patients with stable vitiligo. Material and methods: Forty patients with localized stable vitiligo were randomly divided into 2 groups of 20 each. In group A, patients were treated with microneedling alone and in group B, microneedling was followed by 5-flurouracil cream application every two weeks for 2 months and patients were followed up for 4 months after the last session. Repigmentation was assessed by grades ranging from grade 0 (G0) as no response to G4 as excellent response with > 75% repigmentation and any side effects were noted. Results: Microneedling followed by 5-fluorouracil application showed better response than needling alone with minimal side effects and the results were statistically significant. Conclusions: Microneedling with 5-fluorouracil yields positive therapeutic results in localized stable vitiligo.

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Controlled depth of needling using simple injection needles

Cited by 2 publications

References 2 publications

Microneedling in vitiligo: A systematic review

Microneedling in vitiligo: A systematic review

A single blind active controlled study to compare the efficacy of microneedling and microneedling with 5-flurouracil in treatment of stable vitiligo

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