Controlled Delivery of Drugs from Alginate Matrix

Shilpa, Anu; Agrawal, Shikha; Ray, Alok R.

doi:10.1081/mc-120020160

Cited by 183 publications

(94 citation statements)

References 142 publications

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“…(George & Abraham, 2006), which are the monovalent form of alginic acid belonging to the family of linear copolymers, composed of two monomeric units, β-D-mannuronic acid (M) and α-L-guluronic acid (G). These residues are arranged in homopolymeric blocks (GG and MM) and heteropolymeric blocks (MG) (Smidsrod & Draget, 1996 (Davis et al, 2003;Shilpa et al, 2003). Though alginates have mucoadhesive property, but, the cross-linked alginate beads are usually fragile (Kroll et al, 1996;Llanes et al, 2000).…”

Section: Original Articlesmentioning

confidence: 99%

Novel tamarind seed polysaccharide-alginate mucoadhesive microspheres for oral gliclazide delivery:in vitro–in vivoevaluation

Pal¹,

Nayak²

2012

Drug Delivery

148

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Novel tamarind seed polysaccharide (TSP)-alginate mucoadhesive microspheres were prepared using TSP and alginate as blend in different ratios with different calcium chloride (CaCl 2 ) concentration as a cross linker by ionotropic gelation. The prepared microspheres were of spherical shape having rough surfaces, and average particle sizes within the range of 752.12 ± 6.42 to 948.49 ± 20.92 µm. The drug entrapment efficiency of these microspheres were within the range between 58.12 ± 2.42 to 82.78 ± 3.43% w/w. Fourier transform infrared (FTIR) studies indicated that there were no reactions between gliclazide, and polymers (TSP, and sodium alginate) used. Different formulations of gliclazide loaded TSP-alginate microspheres showed prolonged in vitro release profiles of gliclazide over 12 hours in both stomach pH (pH 1.2), and intestinal pH (pH 7.4). It was found that the gliclazide release in gastric pH was comparatively slow and sustained than intestinal pH. These TSP-alginate microspheres also exhibited good mucoadhesivity. The in vivo studies on alloxan-induced diabetic rats (Animal Ethical Committee registration number: IFTM/837ac/0160) demonstrated the significant hypoglycemic effect of selected formulation of TSP-alginate mucoadhesive microspheres containing gliclazide on oral administration. This developed gliclazide loaded new TSPalginate mucoadhesive microspheres may be very much useful for prolonged systemic absorption of gliclazide for proper maintaining blood glucose level and advanced patient compliance.

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Section: Original Articlesmentioning

confidence: 99%

Novel tamarind seed polysaccharide-alginate mucoadhesive microspheres for oral gliclazide delivery:in vitro–in vivoevaluation

Pal¹,

Nayak²

2012

Drug Delivery

148

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“…These characteristics have enabled alginate to be used as matrix for protein delivery. Alginate is a polyanionic copolymer of guluronic and manuronic acids that can form hydrogel beads through ionotropic gelation by the addition of divalent cations in aqueous liquid [8]. Besides proteins [9,10], the other bioactive agents that can be entrapped into alginate matrices are including cells and DNA [11,12].…”

Section: Introductionmentioning

confidence: 99%

Development of Alginate–Gum Arabic Beads for Targeted Delivery of Protein

Mohamed¹,

Mustafa²,

Fitrianto³

et al. 2017

J Biomol Res Ther

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Controlled release beads were prepared by using the combination of alginate and gum Arabic through ionotropic gelation method. Bovine serum albumin was used as model protein for in vitro assessments. The effect of amount of sodium alginate and gum Arabic as the factor affecting protein encapsulation efficiency and protein release were optimized and analyzed by using RSM-FCCD. It was observed that protein encapsulation efficiency was increased and protein release was decreased with the increase of both of the amount of sodium alginate and gum Arabic, used as polymer blend. The optimized beads showed high encapsulation efficiency (87.5 ± 3.65%) with suitable protein release (100% protein release after almost 4 hrs). The swelling of beads were highly influenced by pH of dissolution medium. These beads were also characterized by FT-IR spectroscopy, SEM and TA for protein-excipients interaction, beads surface morphology and beads strength, respectively. These calcium alginate/gum Arabic beads have good potential to be used as delivery vehicle for protein drugs.

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“…Ultimately a simple, mild, aqueous-based gel is formed by the inonotropic gelling action. [1][2][3][4][5][6][7][8] Theophylline was selected as a model drug for incorporation in electrolyte-alginate beads. Theophylline, an alkaloid found in leaves of Camelia sinensis is used clinically as a bronchodilator in the management of Chronic Obstructive Pulmonary Disease (COPD).…”

Section: Introductionmentioning

confidence: 99%

Effect of Various Electrolytes on Theophylline Loaded Sodium Alginate Beads Prepared by Ionic Cross Linking Technique

Jahan

Mohammad

Sadat

et al. 2013

Dhaka Univ. J. Pharm. Sci

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ABSTRACT:The purpose of t h e present research work was to prepare alginate beads containing water soluble drug theophylline using ionic cross linking technique, with electrolyte type and concentration as variables. In this study, the beads were characterized and evaluated in respect of their surface morphology, swelling index and in vitro kinetics. The comparative study among the three polyvalent cationic cross linking agents CaCl 2 , BaCl 2 and Al 2 (SO 4 ) 3 were investigated based on their cationic charges. Divalent cation, Ca 2+ and Ba 2+containing beads showed simultaneous decrease in drug release with increasing electrolyte amount. In case of Al 3+-alginate beads, the delay in release was due to the ability of Al 3+ to form three dimensional bonding structure with the sodium alginate inside the beads. As a result, swelling of beads is delayed leading to slow disintegration. Scanning electron microscope (SEM) photomicrographs revealed that with the increase in the electrolyte concentration the density of the cross link is also increased. When the electrolyte concentration is 5 % then the beads surface is rough and rod shape drug is visible. But when the electrolyte concentration is increased from 10 % to 15 % the surface is comparatively smoother and both the swelling property and in vitro drug release are decreased. Most of the formulations followed Higuchi drug release model.

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Controlled Delivery of Drugs from Alginate Matrix

Cited by 183 publications

References 142 publications

Novel tamarind seed polysaccharide-alginate mucoadhesive microspheres for oral gliclazide delivery:in vitro–in vivoevaluation

Novel tamarind seed polysaccharide-alginate mucoadhesive microspheres for oral gliclazide delivery:in vitro–in vivoevaluation

Development of Alginate–Gum Arabic Beads for Targeted Delivery of Protein

Effect of Various Electrolytes on Theophylline Loaded Sodium Alginate Beads Prepared by Ionic Cross Linking Technique

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