Controlled delivery of antibodies from injectable hydrogels

Fletcher, Nathan A.; Babcock, Lyndsey; Murray, Ellen A.; Krebs, Melissa D.

doi:10.1016/j.msec.2015.10.096

Cited by 37 publications

(31 citation statements)

References 16 publications

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“…Nevertheless, note that an inflammatory response has been observed due to the presence of GP (i.e., an increase of macrophage and lymphocyte concentrations, which decreased 3 weeks after injection). Antibodies (immunoglobulin, IgG) or antibodies fragments (Fab antibodies fragments) have also been incorporated into CS/alginate physical hydrogels [106]. These biomacromolecules (incorporated before gelation process) could be slowly released by a diffusion process.…”

Section: Tissue Engineering Applicationsmentioning

confidence: 99%

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Chitosan hydrogels for sustained drug delivery

Peers

Montembault

Ladavière

2020

Journal of Controlled Release

284

148

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Section: Tissue Engineering Applicationsmentioning

confidence: 99%

“…Figure 7. Cumulative release of immunoglobulin (IgG) from hydrogels with various alginate/CS ratios[106] …”

mentioning

confidence: 99%

Chitosan hydrogels for sustained drug delivery

Peers

Montembault

Ladavière

2020

Journal of Controlled Release

284

148

View full text Add to dashboard Cite

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“…The combination of nano-encapsulation and BDC improved the efficiency of 5-FU in the treatment of colorectal cancer [ 29 ]. With the development of nano-biomaterials, these properties have been increasingly applied in microstructure technology [ 16 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ].…”

Section: Alginic Acid and Its Derivativesmentioning

confidence: 99%

The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems

et al. 2020

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In recent years, researchers across various fields have shown a keen interest in the exploitation of biocompatible natural polymer materials, especially the development and application of seaweed polysaccharides. Seaweed polysaccharides are a multi-component mixture composed of one or more monosaccharides, which have the functions of being anti-virus, anti-tumor, anti-mutation, anti-radiation and enhancing immunity. These biological activities allow them to be applied in various controllable and sustained anti-inflammatory and anticancer drug delivery systems, such as seaweed polysaccharide-based nanoparticles, microspheres and gels, etc. This review summarizes the advantages of alginic acid, carrageenan and other seaweed polysaccharides, and focuses on their application in gel drug delivery systems (such as nanogels, microgels and hydrogels). In addition, recent literature reports and applications of seaweed polysaccharides are also discussed.

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“…The application of such technology for antibodies remains absent clinically, but has generated much research interest [ 225 ]. Controlled release of immunoglobulin over a period of weeks has been demonstrated with microspheres [ 226 ] and thermoresponsive hydrogels [ 225 ]. The challenge remains that the generally high concentrations required for SC-administered antibodies [ 227 ] are likely to cause aggregation within a delivery system, especially one expected to deliver the antibody over a period of months.…”

Section: Polypeptide Deliverymentioning

confidence: 99%

Injectables and Depots to Prolong Drug Action of Proteins and Peptides

et al. 2020

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Proteins and peptides have emerged in recent years to treat a wide range of multifaceted diseases such as cancer, diabetes and inflammation. The emergence of polypeptides has yielded advancements in the fields of biopharmaceutical production and formulation. Polypeptides often display poor pharmacokinetics, limited permeability across biological barriers, suboptimal biodistribution, and some proclivity for immunogenicity. Frequent administration of polypeptides is generally required to maintain adequate therapeutic levels, which can limit efficacy and compliance while increasing adverse reactions. Many strategies to increase the duration of action of therapeutic polypeptides have been described with many clinical products having been developed. This review describes approaches to optimise polypeptide delivery organised by the commonly used routes of administration. Future innovations in formulation may hold the key to the continued successful development of proteins and peptides with optimal clinical properties.

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Controlled delivery of antibodies from injectable hydrogels

Cited by 37 publications

References 16 publications

Chitosan hydrogels for sustained drug delivery

Chitosan hydrogels for sustained drug delivery

The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems

Injectables and Depots to Prolong Drug Action of Proteins and Peptides

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