Controlled Comparison of Tianeptine, Alprazolam and Mianserin in the Treatment of Adjustment Disorders with Anxiety and Depression

Abstract

A multicentre study compared tianeptine (37.5 mg/day), an original psychotropic compound characterized by both antidepressant and anxiolytic potentials, with a reference antidepressant, mianserin (60 mg/day) and a reference anxiolytic, alprazolam (1.5 mg/day), in the treatment of 152 patients fulfilling DSM-III-R criteria for adjustment disorder with mixed emotional features (anxiety and depression). The study used a double-blind parallel design over a 6-week period. Clinical assessments included the Clinical Global Impressions (CGI), the Montgomery and Asberg depression rating scale (MADRS), the Hamilton anxiety rating scale, a visual analogue scale, and the somatic scale of the system developed by the Association for the Methodology and Documentation in Psychiatry (AMDP). Results showed very similar improvement in the three treatment groups on all rating instruments. Moreover, the number of patients exhibiting adverse events did not differ among the three groups. Therefore, these results show similar antidepressant and anxiolytic activity for tianeptine, mianserin and alprazolam in patients suffering from adjustment disorder with mixed emotional features. These promising findings should however be confirmed in a placebo-controlled trial.

Mechanisms by Which Physical Activity Modulates the Wnt/β-catenin Pathway to Alleviate Anxiety-like Depression

“…The sleep deprivation caused by the fast pace of life and increased stress has led to the increasing prevalence of "sleep deficit" and sleep insufficiency related diseases, which has brought more and more serious physiological and psychological burdens to human beings [15][16].Sleep deprivation(SD) means that the sleep time is less than the average level of the population [17].The acute sleep deprivation (ASD) of individuals deprived of more than 24-48 hours of sleep at one time and the chronic sleep deprivation (CSD) of individuals which deprives individuals of less than 5-6 hours of sleep every day for a long period of time, are two main patterns of sleep deprivation. SD is closely related to cancer [18], hypertension [19], coronary heart disease [20], diabetes [21], and stress reaction [22].…”

Pharmacotherapy of adjustment disorder: A review

“…A first comparative trial for adjustment disorder compared mianserin (an antidepressant, at 60 mg/day), alprazolam (a benzodiazepine, at 1.5 mg/day) and tianeptine (a psychotropic with both antidepressant and anxiolytic properties, at 37.5 mg/day) (Ansseau et al 1996). One hundred and fifty-two patients with DSM-III-R adjustment disorder with mixed emotional features (anxiety and depression) were studied over 6 weeks.…”