Controlled Clinical Trials: Comparison The efficacy of some Single Topical Scabies Treatment Modalities versus Combined Topical Modalities

Ibraheem, Nisreen M.

doi:10.5958/0974-360x.2019.00229.4

Cited by 1 publication

(3 citation statements)

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“…Scabies is among the commonest transmissible diseases round the globe. 1 It is a parasitic infection of the skin which is caused by a mite named Sarcoptes scabiei. 1 It is transmissible by direct contact and is characterized by intense itching and formation of nodules, papules and vesicles over the skin.…”

Section: Introductionmentioning

confidence: 99%

“…1 It is a parasitic infection of the skin which is caused by a mite named Sarcoptes scabiei. 1 It is transmissible by direct contact and is characterized by intense itching and formation of nodules, papules and vesicles over the skin. 1 In few cases, specifically in immunocompromised patients, it can lead to formation of crusts over the skin and hyperinfestation that leads to superimposed bacterial infection which is associated with high rates of morbidity as well as mortality due to septicemia.…”

Section: Introductionmentioning

confidence: 99%

“…1 It is transmissible by direct contact and is characterized by intense itching and formation of nodules, papules and vesicles over the skin. 1 In few cases, specifically in immunocompromised patients, it can lead to formation of crusts over the skin and hyperinfestation that leads to superimposed bacterial infection which is associated with high rates of morbidity as well as mortality due to septicemia. 2 According to the study on the Global Burden of Disease, it was revealed that scabies was prevalent in 200 million people, globally.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and safety of oral ivermectin combined with topical permethrin in treatment of scabies.

Saman Iqbal Goraya,

Safoora Aamir,

Beenish Jabeen Bajwa

et al. 2023

TPMJ

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Objective: To determine the efficacy and safety of oral ivermectin and topical permethrin when given either alone or in combination in patients with scabies. Study Design: Randomized Controlled Trial. Setting: Department of Dermatology, Sheikh Zayed Hospital, Lahore. Period: April, 2022 to September, 2022. Material & Methods: A total of 369 patients with scabies, age 18-60 years and both genders were enrolled after taking written informed consent and were randomly and equally divided into three groups. Group A received 5% topical permethrin, Group B received oral Ivermectin and Group C received a combination of topical permethrin and oral ivermectin. Efficacy and safety was assessed over 3 weeks. Results: The mean age of the patients was 4110.9. There were 164 (44.4%) males and 205 (55.6%) females. The treatment in Group A, B and C was efficacious in 70.7%, 67.5% and 84.6% patients respectively and there was a significant difference between Group A versus C (p=0.009) and Group B versus C (p=0.002). In terms of side effects, 11.4% patients in Group A, 13% in Group B and 17% in Group C experienced side effects. Conclusion: The combination therapy was more efficacious than either treatment alone in patients with scabies, however, the side effects were more compared to single agent.

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Section: Introductionmentioning

confidence: 99%