Controlled, Blindly Rated, Direct-Interview Family Study of a Prepubertal and Early-Adolescent Bipolar I Disorder Phenotype

Geller, Barbara; Tillman, Rebecca; Bolhofner, Kristine; Zimerman, Betsy; Strauss, Nancy A.; Kaufmann, Patricia

doi:10.1001/archpsyc.63.10.1130

Cited by 87 publications

(87 citation statements)

References 88 publications

(117 reference statements)

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“…Our data also support findings in generally younger samples (Geller, et al, 2006, Wozniak, et al, 1995 of the substantial clinical impairment in adolescents with BPD in terms of other cognitive and psychiatric comorbidities. Adolescent-onset BPD, more conduct symptoms and higher rates of cycling distinguished BPD youth with and without SUD.…”

Section: Discussionsupporting

confidence: 89%

“…The literature also documents the concurrent, face, and predictive validity of BPD in childhood (Biederman, et al, 2003). Recent work suggests that pediatric onset BPD may represent a unique developmental type of BPD characterized by a chronic course, mixed presentations, and high levels of severe irritability , Biederman, et al, 2003, Carlson, 1984, Geller, et al, 2006, Geller, et al, 2004, Wozniak, et al, 1995. For instance, two ongoing multisite, National Institute of Mental Health (NIMH) funded studies show that children and adolescents with BPD maintain a functionally impaired status characterized by a highly relapsing and remitting course , Birmaher, 2004, Geller, et al, 2006, Geller, et al, 2004.…”

Section: Introductionmentioning

confidence: 99%

“…Recent work suggests that pediatric onset BPD may represent a unique developmental type of BPD characterized by a chronic course, mixed presentations, and high levels of severe irritability , Biederman, et al, 2003, Carlson, 1984, Geller, et al, 2006, Geller, et al, 2004, Wozniak, et al, 1995. For instance, two ongoing multisite, National Institute of Mental Health (NIMH) funded studies show that children and adolescents with BPD maintain a functionally impaired status characterized by a highly relapsing and remitting course , Birmaher, 2004, Geller, et al, 2006, Geller, et al, 2004. BPD is a substantial cause of psychiatric morbidity among youth including high rates of hospitalization, disruption of the family environment, and psychosocial disability (Akiskal, et al, 1985, Geller, et al, 2002a, Weller, et al, 1995, West, et al, 1996, Wozniak, et al, 1993.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study

Wilens

Biederman

Adamson

et al. 2008

Drug and Alcohol Dependence

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study

Wilens

Biederman

Adamson

et al. 2008

Drug and Alcohol Dependence

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“…Depression in mothers has been identified as a major environmental risk factor for ODD and CD symptoms independent of the presence of ADHD in the children [21,59]. The suggested comorbidity of ADHD and bipolar disorder [6,30] is not supported by a recent family study indicating that bipolar disorder-I in children and adults are the same diathesis, and ADHD is another, unrelated disorder [35].…”

Section: Mdd/anxietymentioning

confidence: 99%

Phenotypic and measurement influences on heritability estimates in childhood ADHD

Freitag

Rohde

Lempp

et al. 2010

Eur Child Adolesc Psychiatry

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Twin studies described a strongly heritable component of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. However, findings varied considerably between studies. In addition, ADHD presents with a high rate of comorbid disorders and associated psychopathology. Therefore, this literature review reports findings from population-based twin studies regarding the influence of subtypes, assessment instruments, rater effects, sex differences, and comorbidity rates on ADHD heritability estimates. In addition, genetic effects on the persistence of ADHD are discussed. By reviewing relevant factors influencing heritability estimates more homogeneous subtypes relevant for molecular genetic studies can be elicited. A systematic search of population-based twin studies in ADHD was performed, using the databases PubMed and PsycInfo. Results of family studies were added in case insufficient or contradictory findings were obtained in twin studies. Heritability estimates were strongly influenced by rater effects and assessment instruments. Inattentive and hyperactiveimpulsive symptoms were likely influenced by common as well as specific genetic risk factors. Besides persistent ADHD, ADHD accompanied by symptoms of conduct or antisocial personality disorder might be another strongly genetically determined subtype, however, family environmental risk factors have also been established for this pattern of comorbidity.

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“…In particular, prepubertal-onset BPD may represent a distinct form of the disorder that is genetically related to disruptive behavior disorders, particularly attention-deficit/hyperactivity disorder (Spencer et al, 2001). In one controlled family study (Geller et al, 2006), the prevalence of either bipolar I disorder or recurrent MDD was as high as 46.5% among first-degree relatives of prepubertal/early-adolescent onset BPD probands. In addition, relatives with ADHD were at increased risk of BPD; this is consistent with other studies suggesting that comorbid BPD and ADHD is a familial phenotype (Faraone et al, 2003).…”

mentioning

confidence: 99%

Genetics of bipolar disorder

Smoller

Gardner-Schuster²

2007

Curr Psychiatry Rep

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Bipolar disorder is a mood disorder characterized by impairing episodes of mania and depression. Twin studies have established that bipolar disorder is among the most heritable of medical disorders and efforts to identify specific susceptibility genes have intensified over the past two decades. The search for genes influencing bipolar disorder has been complicated by a paucity of animal models, limited understanding of pathogenesis, and the genetic and phenotypic complexity of the syndrome. Linkage studies have implicated several chromosomal regions as harboring relevant genes, but results have been inconsistent. It is now widely accepted that the genetic liability to bipolar disorder reflects the action of many genes of individually small effect, a scenario for which linkage studies are poorly suited. Thus, association studies, which are more powerful for the detection of modest effect loci, have become the focus of gene-finding research. A large number of candidate genes, including biological candidates derived from hypotheses about the pathogenesis of the disorder and positional candidates derived from linkage and cytogenetic studies, have been evaluated. Several of these genes have been associated with the disorder in independent studies (including BDNF, DAOA, DISC1, GRIK4, SLC6A4, and TPH2), but none has been established. The clinical heterogeneity of bipolar disorder and its phenotypic and genetic overlap with other disorders (especially schizophrenia, schizoaffective disorder, and major depressive disorder) has raised questions about the optimal phenotype definition for genetic studies. Nevertheless, genomewide association analysis, which has successfully identified susceptibility genes for a variety of complex disorders, has begun to implicate specific genes for bipolar disorder (DGKH, CACNA1C, ANK3). The polygenicity of the disorder means that very large samples will be needed to detect the modest effect loci that likely contribute to bipolar disorder. Detailed genetic dissection of the disorder may provide novel targets (both pharmacologic and psychosocial) for intervention.Bipolar disorder (BPD) is a common and serious mental disorder characterized by severe mood symptoms, including episodes of mania or hypomania and depression, occurring with a typically cyclical course. Lifetime risk for BPD has typically been reported to be approximately 1%, though recent estimates are as high as 4%. (Kessler et al., 2005). The personal and societal costs of BPD are enormous: even among adequately-treated individuals, relapse is common and the disorder can be profoundly disabling, resulting in serious economic burden (Kessler et al., 2006) Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production pr...

show abstract

Controlled, Blindly Rated, Direct-Interview Family Study of a Prepubertal and Early-Adolescent Bipolar I Disorder Phenotype

Abstract: Findings support that PEA-BP-I and adult BP-I are the same diathesis, 7 to 8x greater familiality in child vs adult BP-I, and family study validation of PEA-BP-I, including its differentiation from ADHD.

Cited by 87 publications

References 88 publications

Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study

Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study

Phenotypic and measurement influences on heritability estimates in childhood ADHD

Genetics of bipolar disorder

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