Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases

Vyas, Suresh P.; Sihorkar, Vaibhav; Mishra, Vijay

doi:10.1046/j.1365-2710.2000.00261.x

Cited by 112 publications

(84 citation statements)

References 103 publications

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“…3 Therapeutic approaches include surgical techniques and mechanical debridement of the root surfaces and/or treatment of the infection with systemic or local antibiotics. 4 Local delivery of antimicrobial agents is becoming more prevalent since it leads to higher concentration of the drug at the intended site of action using a lower dose with an associated reduction in side effects relative to systemic administration. Mucoadhesive tablets, 2 dentifrices, mouth rinses, dental gels, fibers, compacts, injectable semisolid systems, 3 irrigation devices, 5 films, 6 inserts, 7 and microspheres 8 are local delivery systems that have been tried in the treatment of periodontal diseases.…”

Section: Introductionmentioning

confidence: 99%

Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases

2007

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The main objective of this study was to develop a local, oral mucoadhesive metronidazole benzoate (MET) delivery system that can be applied and removed by the patient for the treatment of periodontal diseases. Mucoadhesive micromatricial chitosan/poly(ε-caprolactone) (CH/PCL) films and chitosan films were prepared. Thermal behavior, morphology, and particle size measurements were used to evaluate the prepared films. The effect of different molar masses of CH and different ratios of medium Mwt molar mass chitosan (MCH):PCL on water absorption, in vitro bioadhesion, mechanical properties, and in vitro drug release was examined. In vivo performance of the selected formulation was also evaluated. Differential scanning calorimetry examination revealed that MET existed mainly in amorphous form. Under microscopic examination, PCL microparticles were homogeneously dispersed in the films. The use of different molar masses of CH and different ratios of (MCH):PCL affected the size of the entrapped particles. Addition of PCL significantly decreased percentage water uptake and bioadhesion force compared with pure CH film. With regard to mechanical properties, the 2-layered film containing 1:0.625 MCH:PCL had the best tensile properties. At fixed CH:PCL ratio (1:1.25), the slowest drug release was obtained from films containing high molar mass CH. On the other hand, the 2-layered film that consisted of 1:0.625 MCH:PCL had the slowest MET release. In vivo evaluation of the selected film revealed that metronidazole concentration in saliva over 6 hours ranged from 5 to 15 μg/mL, which was within and higher than the reported range of minimum inhibitory concentration for metronidazole. A significant in vitro/in vivo correlation under the adopted experimental conditions was obtained.

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Section: Introductionmentioning

confidence: 99%

Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases

2007

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“…Magnetite nanoparticles were synthesized inside the vesicles, i.e., the chemical reaction among FeCI 2 , FeCI} and NH} occurred in the core of the newly formed liposomes. The first step was to hydrate the pre-liposomal powder with the solution of the two chlorides (23).…”

Section: Incorporation Of Magnetic Nanoparticles Into Liposomesmentioning

confidence: 99%

Sub-Micrometric Liposomes as Drug Delivery Systems in the Treatment and Periodontitis

Turi

Riggio

Vittorio

et al. 2012

Int J Immunopathol Pharmacol

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Periodontitis is a complex disease and bacterial infection is one of the most common factors involved in this disease. Current strategies for the local delivery of antibiotics do not allow a complete clearance of bacteria filling dentinal tubules and this limits their therapeutic efficacy. Therefore, there is a strong need for the development of new delivery strategies aimed at improving the efficacy of antibiotic therapy for periodontitis with special reference to their ability to penetrate into the tubules. The aim of the present study is to develop liposome-based delivery systems of sub-micron dimension, able to diffuse into the dentinal tubules. A further aim of the research is to develop a protocol for enhanced diffusion based on the use of magnetic liposomes and magnetic fields. Liposomes were produced by hydration of a pre-liposomal formulation. The vesicles were stabilised with PEG and their re-sizing was achieved by extrusion. Magnetite nanoparticles were synthesized inside the vesicles, i.e., the chemical reaction involving FeCI 2 , FeCl 3 and NH 3 occurred within the core of the newly formed liposomes. Dynamic Light Scattering analysis was performed for size characterization. A mathematical model was implemented to predict the diffusion ofthe liposomes in dentinal tubules. Ex-vivo validation was performed on extracted human teeth. We produced PEG-ylated liposomes (average size 204.3 nm) and PEG-ylated magnetic liposomes (average size 286 nm) and an iron content of 4.2f1g/ml. Through mathematical modelling, we deduced that sub-micrometer vesicles are able to penetrate into dentinal tubules. This penetration is considerably more effective when the vesicles are magnetized and subjected to an external magnetic field which accelerates their movement within the tubules. The liposome-based delivery systems developed by the present study are able to penetrate deeply into the tubules, sometimes reaching their terminal ends.Periodontitis is a chronic infectious disease of supporting tissue of the teeth (1). As a consequence of bacterial infection, the periodontal tissue becomes inflamed and is slowly destroyed by the inflammatory process. If left untreated, the teeth lose their ligamentous support to the alveolar bone, become loose and are eventually detached (2). In the early phase of the disease (gingivitis),

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“…Several approaches to treat periodontitis range from mechanical debridement of tooth surfaces to systemic or local administration of antimicrobial agents [2,3]. Because of significant side effects associated with the systemic administration of antibiotics, this approach of treatment should only be used in patients who respond poorly to mechanical treatment [4].…”

Section: Introductionmentioning

confidence: 99%

Development and Physical Characterization of a Periodontal Bioadhesive Gel of Gatifloxacin

2017

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Objective: The aim of this study was to develop a bioadhesive gel of gatifloxacin for the treatment of periodontal diseases.Methods: Periodontal gels of gatifloxacin were prepared using different hydrophilic polymers such as carbopol 940 (CP 940), carboxymethyl cellulose (CMC) and hydroxypropylmethyl cellulose (HPMC) in varied concentrations, either alone or as a combination. The prepared gels were evaluated for their physical appearance, pH, drug content, viscosity, bioadhesiveness and in vitro drug release profile. The influence of the type and the concentration of polymer on the drug release as well as on viscosity and mucoadhesiveness of prepared gels were investigated. Results:The prepared gels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value. Using different polymer types at different concentrations, as well as different polymer combinations, play a significant role in the variation of overall characteristics of formulations. Increasing the concentration of polymer increased the viscosity as well as mucoadhesion, and reduced drug release rate. Formulation F 11 (1 % CP 940 and 5 % CMC) was selected as the formula of choice based on the data of various evaluation parameters such as pH, drug content, viscosity, spreadability and bioadhesion as well as its ability to show a prolonged drug release pattern. Conclusion:The obtained results show that a bioadhesive periodontal gel of gatifloxacin can be prepared using hydrophilic polymers, and by using a combination of polymers the viscosity, mucoadhesiveness, spreadability and release behavior can be optimized.

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Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases

Cited by 112 publications

References 103 publications

Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases

Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases

Sub-Micrometric Liposomes as Drug Delivery Systems in the Treatment and Periodontitis

Development and Physical Characterization of a Periodontal Bioadhesive Gel of Gatifloxacin

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