Controllable polymerization of n-butyl cyanoacrylate using a high-gravity rotating packed bed

Luo

et al. 2020

Ind. Eng. Chem. Res.

The rotating packed bed (RPB) reactor with a lab-scale mesh-pin rotor (MPR) displays the great potential for the chemical processes with viscosity reactants or solid products. However, the scale-up research of the RPB reactor with MPR needs to be taken into consideration, which is the foundation for pilot-scale and industrial application. In this work, the scale-up principles of MPR were proposed for the first time, and the hydrodynamic study was conducted by using a high-speed camera. The liquid flow patterns, impaction–disintegration modes of the droplet with the pin, and droplet diameter and velocity in different zones were investigated. The droplet diameter correlations of different zones were fitted, and the experimental measurements were effectively predicted by the correlations with deviations generally within ±10%. A semiempirical model of droplet velocity was established and validated. The hydrodynamic results were employed to optimize the mass transfer model and illustrate the antiblockage mechanism of the RPB reactor with scale-up MPR.

Section: Scale-up Principlementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Scale-Up of a Rotating Packed Bed Reactor with a Mesh-Pin Rotor: (I) Hydrodynamic Studies

Luo

et al. 2020

Ind. Eng. Chem. Res.

“…High-gravity level β, an important parameter, describes the strength of the high-gravity field, which also represents the intensification degree of the mass transfer and micromixing. 28 The β has a few effects on the droplet size, firstly, the size decreased a little with the β increase; then, it kept almost unchanged when the β continuously increased (Figure 3). Because the oil droplets are so soft, they are easily broken up into smaller droplets in the high-gravity field.…”

Section: Preparation Of the Nanoemulsion By Rpbmentioning

confidence: 98%

<p>Engineering of Long-Term Stable Transparent Nanoemulsion Using High-Gravity Rotating Packed Bed for Oral Drug Delivery</p>

Wang

et al. 2020

IJN

Self Cite

Background: Oil-in-water drug nanoemulsion forms drug delivery systems with high oral bioavailability. The conventional fabrication methods of nanoemulsion are low energy emulsification methods and high energy emulsification methods. However, both two methods are not ideal for industrial production. The problem of low energy emulsification methods is the high dosage of surfactant and co-surfactant which has potential biosecurity issues. What is more, high energy emulsification methods have some disadvantages, like the destruction of drug components, the price of equipment and the difficulties of industrial production. Hence, there have been a few commercial drug nanoemulsions so far. Methods: In this work, we reported a novel method for the fabrication of stable and transparent drug nanoemulsion which contains hydrophilic drug rosuvastatin (ROS) calcium or hydrophobic drug silybinin (SYN) by using high-gravity rotating packed bed (RPB). The drug nanoemulsion was systematically characterized by droplet size, size distribution, stability and in vitro drug release as well as Caco-2 cells permeability. Results: Compared with the self-emulsification method (SE), high-gravity technology could reduce 75% amount of mixed surfactants. The as-prepared nanoemulsion exhibited a very narrow droplet size distribution with a size of 13.53 ± 0.53 nm and a polydispersity index of 0.073 ± 0.018. Meanwhile, the drug nanoemulsion was physicochemically stable at 25°C and 4°C for one-year storage. Furthermore, both ROS and SYN nanoemulsion displayed higher cell permeability and in vitro dissolution than that of commercial formulations. Conclusion: These results demonstrate that RPB can be a potential device to facilitate the industrial production of drug nanoemulsion.

“…Rotating packing bed (RPB) is a novel process intensification device with many applications in absorption [1,2], distillation [3,4], polymerization [5] and waste treatment [6,7], due to its potential to increase the gas-liquid mass transfer [8]. With the characteristics of large gas capacity, low pressure drop and lack of flooding limitation, cross-flow RPB is seen as a promising candidate for the industry application among the clean tail gas with hydrogen sulfide and dust removal than countercurrent-flow RPB [9].…”

Section: Introductionmentioning

confidence: 99%

CFD Simulation of Dry Pressure Drop in a Cross-Flow Rotating Packed Bed

et al. 2021

The cross-flow rotating packed bed (RPB) has attracted wide attention in recent years because of its advantages of large gas capacity, low pressure drop and lack of flooding limitation. However, the complex structure of the packing makes it difficult to obtain the gas flow characteristics in the cross-flow RPB by experiments. In this study, the dry pressure drop in the cross-flow RPB was investigated by computational fluid dynamics (CFD). The packing was modeled by the porous media model and the rotation of the packing was simulated by the sliding mesh model. The simulation results obtained by three turbulence models were compared with experimental results, and the RNG k-ε model was found to best describe the turbulence behaviors in the cross-flow RPB. Then, the effects of gas flow rate and rotating speed on dry pressure drop in different parts of the cross-flow RPB were analyzed. The results of this study can provide important insights into the design and scale-up of cross-flow RPB.