Controllable encapsulation of α-mangostin with quaternized β-cyclodextrin grafted chitosan using high shear mixing

Phunpee, Sarunya; Suktham, Kunat; Surassmo, Suvimol; Jarussophon, Suwatchai; Rungnim, Chompoonut; Soottitantawat, Apinan; Puttipipatkhachorn, Satit; Ruktanonchai, Uracha

doi:10.1016/j.ijpharm.2017.12.016

Cited by 22 publications

(18 citation statements)

References 46 publications

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“…After 3 h, there was almost total inhibition (95%). 80 Additionally, nanoparticles of a water-soluble β-CD and α-mangostin presented cytotoxic activities against A549 lung cancer cells, with an IC 50 of 2.34 µg/mL. 81…”

Section: Polymeric Nanoparticles Of α-Mangostinmentioning

confidence: 99%

“…The nanomicelle uptake was mediated by endocytosis, a finding that indicated intracellular delivery of α-mangostin that could be associated with potential cytotoxicity (IC 50 of 8.9 ± 0.2 μg/mL). 82 Chitosan, PLGA Colloidal extraction solvent evaporation [75] PEG, PLA Emulsion/solvent evaporation techniques [76] PLGA Double emulsion solvent evaporation method [42] EC-MC Spray drying [77] Chitosan, alginate and genipin Ionotropic gelation method [78] β-cyclodextrin Inclusion complex technique [79] β-cyclodextrin-chitosan Inclusion complex [80] β-cyclodextrin Inclusion complex [81] Nanomicelles PVP Solvent evaporation method [82] MPEG and PLA Single-step self-assembly method [83] MPEG and PCL Self-assembly method [84] Liposome nanoparticles Transferrin Thin film hydration [85] Soya lecithin Phase separation coacervation method [86] Cholesterol, Tween 60 and ethanol Film hydration method [87] Solid lipid nanoparticles Lavender essential oil and cetyl palmitate Hot and high-pressure homogenisation techniques [88] PLGA and CD44 thioaptamer Nanoprecipitation combined with self-assembly [89] Nanofibres Thiolated chitosan Electrospinning [90] PVP Electrospinning [91] Metal nanoparticles Ag (silver) Chemical reaction by using silver nitrate (AgNO3) [92] Gold, PEI, cyclodextrin and tanshinone Chemical reaction using polyethyleneimine (PEI) [93] Emulsion nanoparticle Captex 200 P, Tween 80, carbopol 90 and silica Solid self-emulsification [94] Oleic acid, isopropyl myristate, Cremophor EL, Tween 80, carboxymethylcellulose sodium Self-microemulsion [31] In another study, α-mangostin nanomicelles with methoxypoly(ethylene glycol)-poly(lactide) (MPEG-PLA) were developed by a single-step self-assembly method for malignant glioma. In vitro and in vivo assays showed that the α-mangostin/MPEG-PLA nanoparticles inhibited cell growth and induced apoptosis-with cleaved caspase expression, DNA fragmentation, downregulation of antiapoptotic molecules and up-regulation of apoptotic molecules.…”

Section: Nanomicellesmentioning

confidence: 99%

“…Several types of nanoparticles have been formulated for the α-mangostin compound, including nanolipids, nanopolymerics, nanomicelles, nanoliposomes, nanofibers and metal nanoparticles. 19,20,[30][31][32][33][34] The results are substantial, with significantly improved solubility for α-mangostin. Therefore, controlled and targeted drug delivery systems can be created by modified nanoparticle technology.…”

Section: Introductionmentioning

confidence: 99%

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<p>Nanoparticle Drug Delivery Systems for α-Mangostin</p>

Wathoni¹,

Rusdin²,

Motoyama³

et al. 2020

NSA

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α-Mangostin, a xanthone derivative from the pericarp of Garcinia mangostana L., has numerous bioactivities and pharmacological properties. However, α-mangostin has low aqueous solubility and poor target selectivity in the human body. Recently, nanoparticle drug delivery systems have become an excellent technique to improve the physicochemical properties and effectiveness of drugs. Therefore, many efforts have been made to overcome the limitations of α-mangostin through nanoparticle formulations. Our review aimed to summarise and discuss the nanoparticle drug delivery systems for α-mangostin from published papers recorded in Scopus, PubMed and Google Scholar. We examined various types of nanoparticles for α-mangostin to enhance water solubility, provide controlled release and create targeted delivery systems. These forms include polymeric nanoparticles, nanomicelles, liposomes, solid lipid nanoparticles, nanofibers and nanoemulsions. Notably, nanomicelle modification increased α-mangostin solubility increased more than 10,000 fold. Additionally, polymeric nanoparticles provided targeted delivery and significantly enhanced the biodistribution of α-mangostin into specific organs. In conclusion, the nanoparticle drug delivery system could be a promising technique to increase the solubility, selectivity and efficacy of α-mangostin as a new drug candidate in clinical therapy.

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Section: Polymeric Nanoparticles Of α-Mangostinmentioning

confidence: 99%

Section: Nanomicellesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

<p>Nanoparticle Drug Delivery Systems for α-Mangostin</p>

Wathoni¹,

Rusdin²,

Motoyama³

et al. 2020

NSA

View full text Add to dashboard Cite

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“…Interestingly, α-mangostin also has been conjugated or modified to be more soluble and potent against bacteria/fungi. Phunpee et al (2018) revealed that α-mangostin forming inclusion complex with quaternized β-tD grafted-chitosan (QCD-g-CS) was able to inhibit Streptococcus mutans ATCC 25177 and Candida albicans ATCC 10231 growth with MIC values of 6.4 and 25.6 mg/mL, respectively. The soluble inclusion complex also possessed higher anti-inflammatory response than free α-mangostin (Phunpee et al 2018), suggesting solubility may be critical in determining the compound effectiveness.…”

Section: Anti-microbesmentioning

confidence: 99%

“…Phunpee et al (2018) revealed that α-mangostin forming inclusion complex with quaternized β-tD grafted-chitosan (QCD-g-CS) was able to inhibit Streptococcus mutans ATCC 25177 and Candida albicans ATCC 10231 growth with MIC values of 6.4 and 25.6 mg/mL, respectively. The soluble inclusion complex also possessed higher anti-inflammatory response than free α-mangostin (Phunpee et al 2018), suggesting solubility may be critical in determining the compound effectiveness. Furthermore, α-mangostin has also been synthetically modified to several analogs particularly at the functional phenolic and iso-prenyl hydroxy groups PeerJ reviewing PDF | (2018:09:30985:1:1:NEW 30 Nov 2018)…”

Section: Anti-microbesmentioning

confidence: 99%

Peer Review #2 of "Recent updates on metabolite composition and medicinal benefits of mangosteen plant (v0.2)"

2019

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Background. Mangosteen (Garcinia mangostana L.) fruit has unique sweet-sour taste and rich in beneficial compounds such as xanthones. Mangosteen has been originally used in various folk medicines to treat diarrhea, wound and fever. More recently, it has been used as a major component in health supplement products for weight loss and promoting general health. This is perhaps due to its known medicinal benefits including as anti-oxidant and anti-inflammation. Interestingly, the publications related to mangosteen has surged in recent years suggesting its popularity and usefulness in research laboratories. However, there is still no updated reviews (up to 2018) in this booming research area, particularly on its metabolite composition and medicinal benefits. Method. In this review, we have covered recent articles within the year of 2016 to 2018, which focuses on several aspects including the latest findings on compound composition from mangosteen fruit as well as its medicinal usages. Result. Mangosteen has been vastly used in medicinal area including as anti-cancer, anti-microbial and anti-diabetes treatments. Furthermore, we have also described the benefits of mangosteen extract in protecting various human organs such as liver, skin, joint, eye, neuron, bowel and cardiovascular tissues against disorders and diseases. Conclusion. All in all, this review describes the numerous manipulations of mangosteen extracted compounds in medicinal areas and highlights the current trend of its research. This will be important for future directed research and may allow researchers to tackle the next big challenge in mangosteen study; drug development and human applications.

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