Controllable biodegradability, drug release behavior and hemocompatibility of PTX-eluting magnesium stents

Lü, Ping; Fan, Hainan; Liu, Yin; Cao, Lei; Wu, Xiang-Feng; Xu, Xinhua

doi:10.1016/j.colsurfb.2010.10.038

Cited by 70 publications

(46 citation statements)

References 21 publications

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“…[21][22][23] The observed stimulation of HCAEC proliferation in a concentration range of 6.25-25 mM magnesium emphasizes the demand for controlled magnesium stent corrosion and the related magnesium ion release. Potential approaches in this direction may be magnesium stent coatings based on corrosion inhibiting ceramics or hydrophobic polymers, as recently suggested by Lu et al 38,39 …”

Section: Resultsmentioning

confidence: 96%

Magnesium used in bioabsorbable stents controls smooth muscle cell proliferation and stimulates endothelial cells in vitro

et al. 2011

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Magnesium-based bioabsorbable cardiovascular stents have been developed to overcome limitations of permanent metallic stents, such as late stent thrombosis. During stent degradation, endothelial and smooth muscle cells will be exposed to locally high magnesium concentrations with yet unknown physiological consequences. Here, we investigated the effects of elevated magnesium concentrations on human coronary artery endothelial and smooth muscle cell (HCAEC, HCASMC) growth and gene expression. In the course of 24 h after incubation with magnesium chloride solutions (1 or 10 mM) intracellular magnesium level in HCASMC raised from 0.55 ± 0.25 mM (1 mM) to 1.38 ± 0.95 mM (10 mM), while no increase was detected in HCAEC. Accordingly, a DNA microarray-based study identified 69 magnesium regulated transcripts in HCAEC, but 2172 magnesium regulated transcripts in HCASMC. Notably, a significant regulation of various growth factors and extracellular matrix components was observed. In contrast, viability and proliferation of HCAEC were increased at concentrations of up to 25 mM magnesium chloride, while in HCASMC viability and proliferation appeared to be unaffected. Taken together, our data indicate that magnesium halts smooth muscle cell proliferation and stimulates endothelial cell proliferation, which might translate into a beneficial effect in the setting of stent associated vascular injury.

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Section: Resultsmentioning

confidence: 96%

Magnesium used in bioabsorbable stents controls smooth muscle cell proliferation and stimulates endothelial cells in vitro

et al. 2011

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“…19 Since biodegradable or bioresorbable implants with sufficient tenacity are crucial, study for biodegradable metals such as Mg and Mg alloys are increasing. 20 Ping Lua 21 with colleagues reported controllable biodegradability PTX-eluting magnesium stents by fabricating a micro-arc-oxidation/poly-l-lactic acid composite coating on the magnesium alloy AZ81 substrate. However, this kind of magnesium alloy, such as AZ91 and AZ81, contain several percents of Al, whose ions may cause Alzheimer's disease.…”

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confidence: 99%

Electrochemical Deposition of Cisplatin on Pure Magnesium

Lai

Lin

Hsu

et al. 2018

J. Electrochem. Soc.

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In this research, the cisplatin has been successfully deposited on pure Mg specimen, degradable and promising for the tumor treatment by its local sustained release to prevent the cancer from metastasis and even to achieve its apoptosis. The cathodic polarization tests coupled with electrochemical reactions in various concentrations of cisplatin solutions were qualitatively and quantitatively analyzed to speculate the deposition mechanism of cisplatin by UV visible spectrometer, Fourier transform infrared spectroscopy, field emission scanning electron microscope coupled with energy-dispersive spectroscopy, focused ion beam, and X-ray diffractometer. The drug, cisplatin, is deposited on the pure Mg through exchanging Cl − with OH − , produced by the electrochemical method, to form strong hydrogen bonds for attracting one another. The FESEM images of cisplatin coated Mg specimens reveal that the diameter of cisplatin particle is around 50-150 nm with sphere-like shape. While that on cisplatin/HAp composite is less than 30 nm. Due to the high porosity, the drug loading on cisplatin/HAp coated one can be enhanced from 34.65 to 84.93 μg/cm 2 . Also, the drug release duration can be elongated from one day burst to 3 weeks sustained release, which is promising for future clinical applications. There are many ways to treat cancer, including surgery, chemotherapy, radiotherapy, targeted therapy and so on. Among all these therapeutic methods, the conventional drug administration method, chemotherapy, is an indispensable choice for its high efficiency. Though widely utilized, it causes severe complications. In fact, chemotherapy affects people systemically, which kills not only tumor cells but also normal cells like immune cells. In many situations, people can't help but stop chemotherapy treatment before cancer cells eradicated due to severe side effects including mouth sores, hypersensitivity reactions, nausea, vomiting, diarrhea, low blood counts and hair loss.1 Current development of carriers to release drugs locally at controlled rate, which are more specific and safe due to dramatic reducing the side effects, are interesting and spotlighted. 2-5Over the last 40 years, platinum-based drugs become the significant medicines for cancer therapy, approximately half of cancer patients undergo platinum-based drugs chemotherapeutic treatment. Cisplatin and carboplatin are two major platinum-based drugs used in chemotherapy.5 Cis-diamminedichloroplatinum (II) (CDDP), commonly called cisplatin, is the first anticancer drug, which was discovered in 1965 and approved for clinical use in 1978. 6 It is the preferred medicine for a variety of solid tumors, such as testicular and ovarian cancers, and is also used for treating bladder, cervical, esophageal, and small cell lung cancer. The success in cisplatin-based chemotherapy drugs strongly depends on how careful the drug's dosages are monitored in order to reduce severe side-effects. 5,7 This show how important the localized cancer treatment is through sustaining drug release, ac...

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“…The low corrosion potential of Mg and its alloys makes them susceptible to dissolution in aqueous solutions, particularly in electrolytes containing chloride ions [1,2]. The Mg alloys used in biomedical materials have received much attention in recent years because of their excellent degradability, which afford alternative biomedical materials for treating cardiovascular diseases [3][4][5].…”

Section: Introductionmentioning

confidence: 99%