Control over spinal nociception as quantified by the nociceptive flexor reflex (<scp>RIII</scp> reflex) can be achieved under feedback of the <scp>RIII</scp> reflex

Ruscheweyh, Ruth; Weinges, Fabian; Schiffer, Manuela; Bäumler, Maximilian; Feller, M.; Krafft, Stefanie; Straube, Andreas; Sommer, Jens; Marziniak, Martin

doi:10.1002/ejp.570

Cited by 15 publications

(34 citation statements)

References 39 publications

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“…1). Subjects in the sham feedback group believed that they received feedback on their RIII reflex size, but instead received feedback corresponding to the reflex size course of a subject from the previous study, 28 who had successfully learned to suppress his reflex to an average of 74% of control. During task blocks, indicated on the feedback screen by green bars and a blinking downward arrow, subjects had the task to use cognitive and/or emotional strategies with the aim to reduce their RIII reflex size.…”

Section: Methodsmentioning

confidence: 99%

“…28 Feedback training was performed in 3 sessions (8.5 6 9.2 days apart), which consisted of one 8-minute stabilization run (not analyzed), one SEP painless run, 2 sham or true feedback training runs, and one heat pain rating run (Fig. 1).…”

Section: Methodsmentioning

confidence: 99%

“…In the sham feedback group, procedures and instructions were identical, but subjects inadvertently received a false feedback, corresponding to the RIII reflex area course of a subject who had successfully learned to suppress his RIII reflex in the previous study. 28 Somatosensory evoked potentials were recorded in parallel to the RIII reflex during feedback runs. Thirteen subjects who had an average RIII reduction during task block of ,80% of pretask participated in an additional session, where F-waves were recorded at the middle of each block.…”

Section: Methodsmentioning

confidence: 99%

“…30,32 Our hypothesis therefore is that during RIII feedback training, subjects learn to use cognitive-emotional strategies to activate their descending pain inhibitory systems, which might be an interesting new option for pain treatment. 28 However, it remains to be shown that learned suppression of the RIII reflex indeed affects supraspinal nociception. To address this issue, in this study, we recorded late somatosensory evoked potentials (SEPs) in parallel with the RIII reflex.…”

Section: Introductionmentioning

confidence: 99%

“…5,34,35 In a recent study, we showed that healthy young subjects can learn to use cognitive-emotional strategies to suppress their nociceptive flexor reflex (RIII reflex), when given feedback about this parameter. 28 The RIII reflex is considered a measure of spinal nociceptive transmission. 30,32 Our hypothesis therefore is that during RIII feedback training, subjects learn to use cognitive-emotional strategies to activate their descending pain inhibitory systems, which might be an interesting new option for pain treatment.…”

Section: Introductionmentioning

confidence: 99%

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Learned control over spinal nociception reduces supraspinal nociception as quantified by late somatosensory evoked potentials

Ruscheweyh

Bäumler²,

Feller³

et al. 2015

Pain

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We have recently shown that subjects can learn to use cognitive-emotional strategies to suppress their spinal nociceptive flexor reflex (RIII reflex) under visual RIII feedback and proposed that this reflects learned activation of descending pain inhibition. Here, we investigated whether learned RIII suppression also affects supraspinal nociception and whether previous relaxation training increases success. Subjects were trained over 3 sessions to reduce their RIII size by self-selected cognitive-emotional strategies. Two groups received true RIII feedback (with or without previous relaxation training) and a sham group received false feedback (15 subjects per group). RIII reflexes, late somatosensory evoked potentials (SEPs), and F-waves were recorded and pain intensity ratings collected. Both true feedback groups achieved significant (P < 0.01) but similar RIII suppression (to 79% ± 21% and 70% ± 17% of control). Somatosensory evoked potential amplitude (100-150 milliseconds after stimulation) was reduced in parallel with the RIII size (r = 0.57, P < 0.01). In the sham group, neither RIII size nor SEP amplitude was significantly reduced during feedback training. Pain intensity was significantly reduced in all 3 groups and also correlated with RIII reduction (r = 0.44, P < 0.01). F-wave parameters were not affected during RIII suppression. The present results show that learned RIII suppression also affects supraspinal nociception as quantified by SEPs, although effects on pain ratings were less clear. Lower motor neuron excitability as quantified by F-waves was not affected. Previous relaxation training did not significantly improve RIII feedback training success.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Learned control over spinal nociception reduces supraspinal nociception as quantified by late somatosensory evoked potentials

Ruscheweyh

Bäumler²,

Feller³

et al. 2015

Pain

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Learned control over spinal nociception in patients with chronic back pain

Krafft

Göhmann

Sommer

et al. 2017

European Journal of Pain

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Drug Discovery and Evaluation: Methods in Clinical Pharmacology

Hock¹,

Gralinski²

2020

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Despite many advances in the last decades in understanding pain, the development of new analgesic compounds has not followed at the same pace. The development of more targeted analgesic compounds with fewer side effects is therefore essential. With an increased demand to demonstrate pharmacodynamic effects of new analgesic compounds, the importance of human evoked pain models is now higher than ever.Pharmacodynamic evaluation with human evoked pain models offers the possibility to determine the dose ranges at which new analgesics exert their pharmacological effect. Pain models may also aid in the choice of target population, determine which modality of pain a new drug is expected to be most suitable, help to differentiate between a central or more peripheral mode of action of new drugs, and help determine which other effects contribute to its mode of action, e.g., sedation.Human evoked pain models are conducted in standardized laboratories where factors like

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Control over spinal nociception as quantified by the nociceptive flexor reflex (RIII reflex) can be achieved under feedback of the RIII reflex

Cited by 15 publications

References 39 publications

Learned control over spinal nociception reduces supraspinal nociception as quantified by late somatosensory evoked potentials

Learned control over spinal nociception reduces supraspinal nociception as quantified by late somatosensory evoked potentials

Learned control over spinal nociception in patients with chronic back pain

Drug Discovery and Evaluation: Methods in Clinical Pharmacology

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