2018
DOI: 10.1016/j.cub.2018.10.048
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Control of Xenopus Tadpole Locomotion via Selective Expression of Ih in Excitatory Interneurons

Abstract: SummaryLocomotion relies on the coordinated activity of rhythmic neurons in the hindbrain and spinal cord and depends critically on the intrinsic properties of excitatory interneurons. Therefore, understanding how ion channels sculpt the properties of these interneurons, and the consequences for circuit function and behavior, is an important task. The hyperpolarization-activated cation current, Ih, is known to play important roles in shaping neuronal properties and for rhythm generation in many neuronal networ… Show more

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Cited by 25 publications
(36 citation statements)
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(82 reference statements)
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“…Dysregulation of intrinsic plasticity affects the network dynamics (Tien and Kerschensteiner, 2018), and can lead to a loss of function (Marcelin et al, 2009). And yet, with the possible exception of oscillatory networks (Marder and Taylor, 2011;Picton et al, 2018), the exact ways in which intrinsic plasticity contributes to network tuning, remain unclear. We know that neurons adjust their spikiness to match the levels of synaptic activation they experience (Aizenman et al, 2003;Titley et al, 2017), but we also know that intrinsic properties can affect more subtle neuronal tuning to different temporal patterns of activation (Azouz and Gray, 2000;Branco et al, 2010;Fontaine et al, 2014;Jarvis et al, 2018;Ohtsuki and Hansel, 2018;Zbili et al, 2019).…”
Section: Introductionmentioning
confidence: 99%
“…Dysregulation of intrinsic plasticity affects the network dynamics (Tien and Kerschensteiner, 2018), and can lead to a loss of function (Marcelin et al, 2009). And yet, with the possible exception of oscillatory networks (Marder and Taylor, 2011;Picton et al, 2018), the exact ways in which intrinsic plasticity contributes to network tuning, remain unclear. We know that neurons adjust their spikiness to match the levels of synaptic activation they experience (Aizenman et al, 2003;Titley et al, 2017), but we also know that intrinsic properties can affect more subtle neuronal tuning to different temporal patterns of activation (Azouz and Gray, 2000;Branco et al, 2010;Fontaine et al, 2014;Jarvis et al, 2018;Ohtsuki and Hansel, 2018;Zbili et al, 2019).…”
Section: Introductionmentioning
confidence: 99%
“…The model was a single CPG composed of two inhibitory half centres, with IPump, Ih, and INaP currents. We derived these parameters from insights based on studies on the dynamic roles of the IPump in the regulation of the leech heartbeat (Kueh et al, 2016;Tobin and Calabrese, 2005) and Xenopus tadpole locomotor CPGs (Picton et al, 2018;Zhang et al, 2015;Zhang and Sillar, 2012).…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, in the Xenopus tadpole spinal cord CPG, Ih is expressed only in glutamatergic rhythmgenerating interneurons (dINs), where it opposes and cancels out the inhibitory IPump. Further, blockade of Ih disrupts STMM (Picton et al, 2018), suggesting that a balance between IPump and Ih is required for STMM. IPump also interacts with Ih in leech heartbeat neurons, which accounts for the paradoxical speeding up of the rhythm when IPump is increased experimentally with monensin (Kueh et al, 2016).…”
Section: Dynamic Mechanisms Lead To Transitions Between Episodic and mentioning
confidence: 98%
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