Control of Tourette’s Syndrome With Topiramate

A randomised, double-blind, placebo-controlled study of topiramate in the treatment of Tourette syndrome

“…There were also improvements in other components of the YGTSS (table 2) and in CGI and premonitory CGI. Our results are consistent with a report describing two adult TS patients whose symptoms apparently improved with topiramate (50–200 mg/day) while previous medications were tapered and discontinued during the first 2 weeks of treatment 8. Topiramate in our study was well tolerated, but some of the commonly observed topiramate adverse effects, such as somnolence, cognitive problems and weight loss, may not have been evident because the trial duration was relatively short.…”

Topiramate for the Treatment of Chronic Corneal Pain

“…27,28 It is also advocated for the treatment of cluster headaches, 29 essential tremor, 30 bingeeating disorder, 31 acute mania, 32 and Tourette syndrome. 33 Topiramate has not been found to be effective for central pain secondary to brain or spinal cord injury. 34 Topiramate blocks voltage-dependent sodium channels, potentiates gamma-aminobutyric acid-mediated chloride currents, and blocks kainate but not N-methyl-D-aspartate glutamate receptors.…”

Mood and Anxiety Symptoms in An Adolescent with Pervasive Developmental Disorder Not Otherwise Specified and Moderate Mental Retardation

“…Alternatively, topiramate has been studied as both a monotherapy and an adjunctive treatment for bipolar disorder in children and adolescents (Barzman et al 2005;DelBello et al 2002a;DelBello et al 2005). Advantages of topiramate might be some beneficial effects on tics/repetitive behaviors as well as mood (Nelson et al 2007;Abuzzahab et al 2001). Possible negative but reversible impact on language function or cognition would require monitoring.…”