2011
DOI: 10.4049/jimmunol.1003410
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Control of TNF-Induced Dendritic Cell Maturation by Hybrid-Type N-Glycans

Abstract: The activity of α-1,2-mannosidase I is required for the conversion of high-mannose to hybrid-type (ConA reactive) and complex-type N-glycans (Phaseolus vulgaris-leukoagglutinin [PHA-L] reactive) during posttranslational protein N-glycosylation. We recently demonstrated that α-1,2-mannosidase I mRNA decreases in graft-infiltrating CD11c+ dendritic cells (DCs) prior to allograft rejection. Although highly expressed in immature DCs, little is known about its role in DC functions. In this study, analysis of surfac… Show more

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Cited by 8 publications
(7 citation statements)
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“…However, recent studies showed that Dectin-2 also recognizes lipomannan, mannoprotein and mannosylated O-antigen that contain terminal mannose [9, 11, 23]. Interestingly, in vertebrates, high mannose-type N-linked glycans are also found on particular type of DC [24]. Gusb is known to contain high mannose type glycans [18].…”
Section: Discussionmentioning
confidence: 99%
“…However, recent studies showed that Dectin-2 also recognizes lipomannan, mannoprotein and mannosylated O-antigen that contain terminal mannose [9, 11, 23]. Interestingly, in vertebrates, high mannose-type N-linked glycans are also found on particular type of DC [24]. Gusb is known to contain high mannose type glycans [18].…”
Section: Discussionmentioning
confidence: 99%
“…A vast amount of data indicate that TNF-α induces the maturation of immature DCs and, moreover, that it induces transcellular migration of DCs, which depends on the production of IL-8. 53,54 The migratory DCs activate T-cells and subsequently initiate the adaptive immune response against invading bacteria and viruses. 55 However, recruitment of TRIF associated with TLR4 results in the activation and nuclear translocation of IRF3, an essential transcription factor generally involved in induction of type I IFN and pro-inflammatory cytokines, such as IL-12, IL-18 and IL-23, in wild type DCs.…”
Section: Discussionmentioning
confidence: 99%
“…FACS data were analyzed using FlowJo software (TreeStar Inc., OR, USA). For proinflammatory cytokine-induced maturation of DCs, BMDCs were treated with CCNVs and recombinant TNF-α (100 ng/ml) and IFN-γ (20 ng/ml) (BioLegend) 34 , 35 . Then, the BMDCs were detached and stained with the following antibodies: APC-Cy7 anti-mouse CD11c antibody, PE anti-mouse CD80 antibody and APC anti-mouse CD86 antibody (BioLegend).…”
Section: Methodsmentioning
confidence: 99%