Control of the unified rhythm of the heart

Mazurov, M. E.

doi:10.1134/s0006350909010126

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…However, recent studies [49,50] have shown that the rhythmic activity of the self-oscillating elements in the group which form the body of the pacemaker is synchronized by more complex laws, and the ascertained earlier variant of synchronization from the element with the highest frequency of the oscillations is only a special case. The problem of the control of cardiac rhythm has been considered in terms of the general theory of the synchronization of relaxation systems, and, as result, the main pathways of the control of cardiac rhythm have been revealed: (1) control with regard for the features of synchronization of relaxation systems during the formation of the unified heart rhythm due to the acceleration of the slow diastole depolarization phase; (2) control by gradual integral increase in the duration of the slow diastole depolarization phase; (3) subsequent synchronization of the rhythm as a delay of the slow diastole depolarization phase.…”

Section: Pacemakersmentioning

confidence: 99%

Basic Mechanisms of Cardiac Arrhythmias

Jalife

Delmar

Anumonwo

et al. 2009

Basic Cardiac Electrophysiology for the Clinician

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Section: Pacemakersmentioning

confidence: 99%

Basic Mechanisms of Cardiac Arrhythmias

Jalife

Delmar

Anumonwo

et al. 2009

Basic Cardiac Electrophysiology for the Clinician

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“…Indisputable evidence for this is the intrinsic rhythmical excitation of the heart (Baruscotti and Robinson 2007;Abramochkin et al 2009;Bradd 2012;Grigoriev and Babich 2015;Murphy and Lazzara 2016;van Weerd and Christoffels 2016;Filyukova 2018). However, from the standpoint of the traditional theory (intercellular interaction due to nexuses and electrotonic influence), it is unlikely to give reasons for combining PC pools (Mazurov 2006(Mazurov , 2009.…”

Section: Introductionmentioning

confidence: 99%

The influence of the vagus nerve and indole derivative SS-68 on excitation processes in the SA node

Nechepurenko,

Galenko-Yaroshevsky,

Pokrovskiy

et al. 2023

RRP

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Introduction: Atrial fibrillation (AF) is the most common form of cardiac arrhythmias. Studying the pathogenesis of this pathological process will make it possible to look for new methods of treating AF and to predict its occurrence in a more targeted way. The aim of the study was to identify the components of the takeover process of central rhythmogenesis by the SA node in the conditions of atrial fibrillation when stimulating the vagus nerve and using substance SS-68. Materials and Methods: The experiments were conducted on 30 frogs and 90 cats. In frogs, the activity of the regions of the medulla oblongata synchronous with the heart rhythm was determined in a high-frequency electromagnetic field. In cats, proximal and distal foci of luminescence in the vagus nerve (VN) and pools of pacemaker cells (PCs) in the sinoatrial node were visualized under topical and general anesthesia, using a KELSY scanner with a microscope video capture unit while stimulating VN and using SS-68. Results and Discussion: The stimulation of VN with volleys of electrical impulses and the introduction of SS-68 increase the foci of luminescence in the nerve and unite the PC pools. This way, under general anesthesia in comparison with topical anesthesia, the area of the proximal focus of VN luminescence decreased by 83.8%, and the distal focus – by 44.9%. Against the background of general anesthesia, the area of the proximal focus of luminescence when stimulating VN with volleys of electrical impulses was by 76.0% larger than before stimulation, and the distal focus – by 72.5%. After the administration of SS-68, there was an increase in the foci of luminescence: under general anesthesia, when compared with topical anesthesia, the area of the proximal foci of luminescence decreased by 86.8%, and the distal one – by 67.1%. Under general anesthesia, the area of the proximal focus of luminescence under conditions of stimulating VN with volleys of electrical impulses was by 82.2% larger than before stimulation and the distal one – by 78.2%. When signals from the brain arrive simultaneously through VN at the PC pools, they are absorbed by the PC pools; the focus of early depolarization becomes wide, which prevents the development of AF. The increased synchronizing influence of VN may be one of the methods for treating autonomic AF, and if its influence decreases, it can be a prognostic factor for the occurrence of recurrent AF. Conclusion: The tonic effect of VN on the heart rhythm through electrical stimulation of the former and the use of SS-68 is manifested in a decreased heart rate: the difference between the initial heart rhythm and the minimal synchronization range boundary. A decrease in the heart rate under the influence of VN prevents paroxysms of AF, but does not completely eliminate the influence of ectopic foci on it.

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“…Las células del marcapasos después de alcanzar el potencial de acción inician un proceso de despolarización autónomo, que al alcanzar el nivel de umbral, dispara de nuevo la generación del potencial de acción. Lo anterior se logra a través de los intercambios de iones de sodio, potasio y calcio, que junto con un complejo mecanismo de canales iónicos dependientes de tiempo y voltaje permiten, además de la autorritmicidad, que el periodo (i.e., frecuencia cardiaca) sea modulado a través de los neurotransmisores depositados por el sistema nervioso autónomo en rangos que pueden variar hasta un 300% de la frecuencia basal (Mazurov, 2008).…”

Section: Análisis De Las Fluctuaciones Morfológicas Cardiacas a Escal...unclassified

Utilización y adaptación de técnicas de la física estadística para el análisis de las fluctuaciones cardiacas

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Control of the unified rhythm of the heart

Cited by 4 publications

References 5 publications

Basic Mechanisms of Cardiac Arrhythmias

Basic Mechanisms of Cardiac Arrhythmias

The influence of the vagus nerve and indole derivative SS-68 on excitation processes in the SA node

Utilización y adaptación de técnicas de la física estadística para el análisis de las fluctuaciones cardiacas

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