Control of RNA processing by a large non-coding RNA over-expressed in carcinomas

Lin, Rui; Roychowdhury-Saha, Manami; Black, Chris; Watt, Andrew T.; Marcusson, Eric G.; Freier, Susan M.; Edgington, Thomas S.

doi:10.1016/j.febslet.2011.01.030

Cited by 75 publications

(56 citation statements)

References 21 publications

(36 reference statements)

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“…There is compelling experimental evidence supporting a functional role for Malat1 in the regulation of cell growth. For instance, partial Malat1 silencing suppresses tumor growth by inhibiting the proliferation and migration of a variety of cancer cells (10,19). Given its important and novel role in promoting cancer cell proliferation and migration, it is surprising that Malat1 has not been well characterized in other mammalian cell types.…”

Section: Discussionmentioning

confidence: 99%

Myostatin-induced inhibition of the long noncoding RNA Malat1 is associated with decreased myogenesis

Watts

Johnsen

Shearer

et al. 2013

American Journal of Physiology-Cell Physiology

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Section: Discussionmentioning

confidence: 99%

Myostatin-induced inhibition of the long noncoding RNA Malat1 is associated with decreased myogenesis

Watts

Johnsen

Shearer

et al. 2013

American Journal of Physiology-Cell Physiology

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“…(Gupta et al 2010), liver (Z. , colorectal (Kogo et al 2011), gastrointestinal (Niinuma et al 2012), and pancreatic (Kim et al 2012) cancers and is proposed to increase tumor invasiveness and metastasis (Gupta et al 2010). MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), another lncRNA associated with various cancers and metastasis (Ji et al 2003;Lin et al 2011), is found to affect the transcriptional and post-transcriptional regulation of cytoskeletal and extracellular matrix genes (Tano et al 2010). lincRNA-p21 (named for its vicinity to the CDKN1A/p21 locus) is upregulated by p53 upon DNA damage and implicated in downstream repressive effects of the p53 pathway, particularly on genes regulating apoptosis, possibly by directing the recruitment of hnRNP-K to its genomic targets (Huarte et al 2010).…”

Section: Implications In Cancermentioning

confidence: 99%

Long Noncoding RNAs: Past, Present, and Future

2013

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Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been implicated in a range of developmental processes and diseases, but knowledge of the mechanisms by which they act is still surprisingly limited, and claims that almost the entirety of the mammalian genome is transcribed into functional noncoding transcripts remain controversial. At the same time, a small number of well-studied lncRNAs have given us important clues about the biology of these molecules, and a few key functional and mechanistic themes have begun to emerge, although the robustness of these models and classification schemes remains to be seen. Here, we review the current state of knowledge of the lncRNA field, discussing what is known about the genomic contexts, biological functions, and mechanisms of action of lncRNAs. We also reflect on how the recent interest in lncRNAs is deeply rooted in biology's longstanding concern with the evolution and function of genomes.T HE past several years have witnessed a steep rise of interest in the study of lncRNAs. Almost on a weekly basis, it seems that a new lncRNA is found to be up-or downregulated in a particular disease, or a new class of noncoding transcripts is uncovered by a transcriptomic study, or a new article heralds a paradigm shift that lncRNAs will bring to our understanding of biology. Without a doubt, the advent of sensitive, high-throughput genomic technologies such as microarrays and next-generation sequencing (NGS) has resulted in an unprecedented ability to detect novel transcripts, the vast majority of which seem not to be derived from annotated protein-coding genes. Despite this explosion of data, however, surprisingly little is known about how lncRNAs function, how many different types of lncRNAs exist, or even whether most of them carry biological significance.In this review, we focus on recently discovered lncRNAs of .200 nt, place these new discoveries in historical context, and outline areas where additional work is needed. The review does not cover "classic" ncRNAs such as ribosomal (r) RNAs, ribozymes, transfer (t)RNAs, small nuclear (sn)RNAs, small nucleolar (sno)RNAs, and telomere-associated RNAs (TERC, TERRA); nor does it cover small ncRNAs such as microRNAs (miRNAs), endogenous small interfering (endo-si)RNAs that participate in RNA interference (RNAi), and Piwi-associated (pi)RNAs. We refer readers to the many

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“…Lin et al 31) found that perturbation of lncRNA RNA (human MALAT1) altered splicing activity of genes that encode the RNA-binding proteins serine/arginine rich (SR) proteins and heterogeneous nuclear ribonucleoproteins (hnRNPs), which themselves participate in RNA processing. Souquere et al 32,33) found that lncRNA-NEAT1 transcripts could constrain the geometry of paraspeckle bodies (PSPs), which prompt nuclear retention of mRNAs with A-I edition at the 3´ end noncoding regions, preventing mRNA translation into protein.…”

Section: Post-transcriptional Regulationmentioning

confidence: 99%