Control of regional decidualization in implantation: Role of FoxM1 downstream of Hoxa10 and cyclin D3

Gao, Fei; Bian, Fenghua; Ma, Xing-Hong; Kalinichenko, Vladimir V.; Das, Sanjoy K.

doi:10.1038/srep13863

Cited by 37 publications

(33 citation statements)

References 64 publications

(125 reference statements)

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“…7A and B; P<0.01). Cyclin D1 and MMP2 are not targets of miR-149, but they have been demonstrated to be regulated by FOXM1 (10,11). Thus, these results may partly explain the anticancer mechanisms of miR-149 in NSCLC.…”

Section: Mir-149 Inhibits Nsclc Tumor Growth and Metastasis In Vivomentioning

confidence: 94%

miR-149 suppresses human non-small cell lung cancer growth and metastasis by inhibiting the FOXM1/cyclinï¿½D1/MMP2 axis

et al. 2017

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Valid evidence has demonstrated that microRNAs have critical functions in cancer genesis and tumor progression. In the present study, aberrant expression of microRNA-149 (miR-149) was confirmed in non-small cell lung cancer (NSCLC) tissues. Low expression of miR-149 was associated with malignant clinical features and poor survival. Gain- and loss-of-function experiments demonstrated that miR-149 inhibited NSCLC tumor growth and metastasis in vitro and in vivo. Furthermore, oncogenic transcription factor FOXM1 was confirmed as a direct target of miR-149 in NSCLC. Cyclin D1 and MMP2 served as downstream targets of FOXM1 and were also inhibited by miR-149. In summary, the present study indicated that downregulation of miR-149 in NSCLC predicted poor clinical outcomes. miR-149 suppresses tumor growth and metastasis in NSCLC by inhibiting the FOXM1/cyclin D1/MMP2 signaling pathway.

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Section: Mir-149 Inhibits Nsclc Tumor Growth and Metastasis In Vivomentioning

confidence: 94%

miR-149 suppresses human non-small cell lung cancer growth and metastasis by inhibiting the FOXM1/cyclinï¿½D1/MMP2 axis

et al. 2017

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“…Mice were sacrificed on D8 between 9:00 and 10:00 a.m. and tissues were collected for the subsequent experiments. Quantitative analyses of regional decidual development were according to the previously described method [15]. There were 15 mice sacrificed in each group.…”

Section: Methodsmentioning

confidence: 99%

Positive Regulation of Decidualization by l-Type Amino Acid Transporter 1 (lat1) in Pregnant Mice

Wang

Tan

et al. 2016

Nutrients

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Amino acids have an important role in the pre and post implantation of placenta and embryo development. l-type amino-acid transporter 1 (lat1) is responsible for the transportation of large neutral amino acids and is mainly expressed in human fetal liver, placenta, brain, etc. This study is the first to investigate the expression of lat1 in the early pregnancy of mouse uteri and its role in the process of decidualization. Endometrial stromal cells of a mouse model were used to evaluate decidualization from Day 4–8 of pregnancy in vitro followed by lat1 knock down by small interfering RNA and by a competitive inhibitor of Leucine transport 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH). The effects of lat1 on decidualization in vivo were assessed by injecting BCH into the uterine horns. The mRNA and protein expressions of lat1 in the implantation sites were higher than that in the inter-implantation sites and were localized in the luminal and gland epithelium, stromal and decidual cells. Its increased expression (p < 0.05) was associated with artificial decidualization as well as activation of prl expression. Down-regulation of lat1 expression in these cells by siRNA and BCH inhibited the decidual progression in vitro. Inhibition of lat1 transportation by BCH controlled decidual progression in vivo also accompanied the down-regulation of prl, lat1 expression in the decidual area and embryo size on Day 8 of pregnancy. In conclusion, these results revealed that lat1 might play an important role in the decidual progression both in vitro and in vivo.

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“…A recent genomic study using these cells identified P response element in the HOXA10 gene promoter, implying that HOXA10 is a direct target of PR in endometrial stromal cells . Interestingly, it has been reported recently that FoxM1 functions downstream of Hoxa10 to control stromal cell proliferation in the mouse and it directs the expression of STAT3 during human endometrial stromal cell differentiation …”

Section: Control Of Uterine Receptivity and Decidualization By Pr‐regmentioning

confidence: 99%

Progesterone‐Regulated Endometrial Factors Controlling Implantation

Bhurke

Bagchi

2016

American J Rep Immunol

126

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The steroid hormone progesterone (P), acting via the progesterone receptor (PR) isoforms, PR-A and PR-B, exerts a profound influence on uterine functions during early gestation. In recent years, chromatin immunoprecipitation-sequencing in combination with microarray-based gene expression profiling analyses have revealed that the PR isoforms control a substantially large cistrome and transcriptome during endometrial differentiation in the human and the mouse. Genetically engineered mouse models have established that several PR-regulated genes, such as Ihh, Bmp2, Hoxa10, and Hand2, are essential for implantation and decidualization. PR-A and PR-B also collaborate with other transcription factors, such as FOS, JUN, C/EBPβ and STAT3, to regulate the expression of many target genes that function in concert to properly control uterine epithelial proliferation, stromal differentiation, angiogenesis, and local immune response to render the uterus ‘receptive’ and allow embryo implantation. This review article highlights recent work describing the key PR-regulated pathways that govern critical uterine functions during establishment of pregnancy.

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Control of regional decidualization in implantation: Role of FoxM1 downstream of Hoxa10 and cyclin D3

Cited by 37 publications

References 64 publications

miR-149 suppresses human non-small cell lung cancer growth and metastasis by inhibiting the FOXM1/cyclinï¿½D1/MMP2 axis

miR-149 suppresses human non-small cell lung cancer growth and metastasis by inhibiting the FOXM1/cyclinï¿½D1/MMP2 axis

Positive Regulation of Decidualization by l-Type Amino Acid Transporter 1 (lat1) in Pregnant Mice

Progesterone‐Regulated Endometrial Factors Controlling Implantation

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