Control of postprandial hyperglycaemia by galactosyl maltobionolactone and its novel anti-amylase effect in mice

Murai, Atsushi; Iwamura, Koji; Takada, Masayasu; Ogawa, Koichi; Usui, Taichi; Okumura, J.

doi:10.1016/s0024-3205(02)01844-1

Cited by 63 publications

(34 citation statements)

References 23 publications

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“…Inflammatory bowel disease is a relative contraindication (4). There are also reports of an increased of renal tumors occurrence and serious hepatic injury and acute hepatitis (46).…”

Section: Phytoconstituents With -Amylase Inhibitory Activitymentioning

confidence: 99%

α-Amylase Inhibitors: A Review of Raw Material and Isolated Compounds from Plant Source

et al. 2012

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-Inhibition of α-amylase, enzyme that plays a role in digestion of starch and glycogen, is considered a strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity, as well as, dental caries and periodontal diseases. Plants are an important source of chemical constituents with potential for inhibition of α-amylase and can be used as therapeutic or functional food sources. A review about crude extracts and isolated compounds from plant source that have been tested for α-amylase inhibitory activity has been done. The analysis of the results shows a variety of crude extracts that present α-amylase inhibitory activity and some of them had relevant activity when compared with controls used in the studies. Amongst the phyto-constituents that have been investigated, flavonoids are one of them that demonstrated the highest inhibitory activities with the potential of inhibition related to number of hydroxyl groups in the molecule of the compound. Several phyto-constituents and plant species as α-amylase inhibitors are being reported in this article. Majority of studies have focused on the anti-amylase phenolic compounds.

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“…Inflammatory bowel disease is a relative contraindication (4). There are also reports of an increased of renal tumors occurrence and serious hepatic injury and acute hepatitis (46).…”

Section: Phytoconstituents With -Amylase Inhibitory Activitymentioning

confidence: 99%

α-Amylase Inhibitors: A Review of Raw Material and Isolated Compounds from Plant Source

et al. 2012

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“…Commercially available antidiabetic drugs such as sitagliptin and saxagliptin are used for DPP-IV inhibition (Bharti et al 2012). Although powerful synthetic α-amylase, α-glucosidase and DPP-IV inhibitors including acarbose, voglibose, sitagliptin and saxagliptin are available, they are known to cause hepatic disorders and other gastrointestinal symptoms (Murai et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic potential of marine algae by inhibiting key metabolic enzymes

Unnikrishnan

Suthindhiran

Jayasri

2015

Frontiers in Life Science

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Two edible seaweeds, Sargassum polycystum and Sargassum wightii, were investigated for their antidiabetic potential using in vitro enzyme inhibitory assays. Among the various extracts, petroleum ether and ethyl acetate extracts of S. wightii showed significant inhibitory effects against α-amylase (IC 50 378.3 μg/ml) and α-glucosidase (IC 50 314.8 μg/ml). Methanol extract of S. wightii showed the highest inhibition against dipeptidyl peptidase-IV (DPP-IV) (IC 50 38.27 μg/ml) and moderate antioxidant activity was observed in acetone extract of S. wightii (44%). Similarly, ethyl acetate extract of S. polycystum showed the highest inhibition against α-amylase (IC 50 438.5 μg/ml) and methanol extract of S. polycystum showed maximum inhibition against α-glucosidase (IC 50 289.7 μg/ml) and DPP-IV (36.94 μg/ml). The antioxidant activity was poor (22%). The extracts were investigated for in vitro cytotoxicity, DNA fragmentation in macrophages and haemolytic activity against erythrocytes, but no notable toxicity was observed with any of the tested extracts. Gas chromatography-mass spectrometry revealed the presence of the antidiabetic compound fucosterol and other major bioactive compounds, giving an insight into the antidiabetic and antioxidant properties of these algae. This study reveals the possible mechanisms of antidiabetic action in vitro, and these two seaweeds may also have an antidiabetic action in vivo.

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“…Although powerful synthetic α-glucosidase inhibitors (e.g., Voglibose) are available, they can cause hepatic disorders and other negative gastrointestinal symptoms (Holman, 1998). Hence, natural α-glucosidase inhibitors from food sources have become attractive therapeutic approach for treating postprandial hyperglycemia (Murai et al, 2002;De Melo et al, 2006). Mulberry, Morus genus, is a deciduous tree native to warm and subtropical regions of Asia, Africa, North America, and southern Europe (PereZ-Gregorio et al, 2011).…”

Section: Changes Of Anti-glucosidase Content and Some Other Charactermentioning

confidence: 99%

Changes of anti-glucosidase content and some other characteristics in mulberry juice during fermentation withLeuconostoc mesenteroides

Zheng¹,

Yu²,

Xiao³

et al. 2014

Acta Alimentaria

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Changes in microbial population, pH, sugar, organic acid, anthocyanins, total soluble phenolics, and anti-glucosidase contents were measured during fermentation of mulberry juice at 30 °C by probiotic Leuconostoc mesenteroides showing rapid growth after an approximately 1-day lag phase and reaching a maximum of 8.6 log CFU ml -1 after 4 d. During the rapid growth phase, the main mulberry juice sugars, glucose and fructose, were largely consumed, and the acidic metabolites, lactic acid and acetic acid, were produced accordingly. A slow decrease in the concentration of the main organic acid, citric acid, was also observed during fermentation. After 4 d fermentation, anthocyanin content showed a 44.4% reduction, but the total amount of soluble phenolics and α-glucosidase inhibitory activity showed no significant changes (P>0.05). This suggests that L. mesenteroides fermentation of mulberry juice is a good strategy to enhance its probiotic value and to decrease the sugar content without changing the anti-glucosidase activity, which is required to reduce postprandial rise in blood glucose.

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Control of postprandial hyperglycaemia by galactosyl maltobionolactone and its novel anti-amylase effect in mice

Cited by 63 publications

References 23 publications

α-Amylase Inhibitors: A Review of Raw Material and Isolated Compounds from Plant Source

α-Amylase Inhibitors: A Review of Raw Material and Isolated Compounds from Plant Source

Antidiabetic potential of marine algae by inhibiting key metabolic enzymes

Changes of anti-glucosidase content and some other characteristics in mulberry juice during fermentation withLeuconostoc mesenteroides

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