Control of pore structure in a porous gold nanoparticle for effective cancer cell damage

Hua, Wei-Hsiang; Cai, Cheng-Jin; Chou, Keng-Ping; Tsai, Yu Lin; Low, Meng Chun; Tu, Charng-Gan; Chen, Chien‐Yu; Ni, Chia-Chun; Kiang, Yean‐Woei; Yang, C. C.; Hsu, Yih-Chih

doi:10.1088/1361-6528/aae8c4

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…In fact, porous gold nanoparticles exhibit extraordinary electrocatalytic activity and stronger plasmon resonance compared to smooth gold nanoparticles [20]. In some cases, plasmon resonance has been reported to be correlated with the porosity of nanoparticles [25]. Notably, porous gold nanoparticles have been synthesized following protocols that were previously listed for PG films [26].…”

Section: Introductionmentioning

confidence: 99%

Porous Gold: A New Frontier for Enzyme-Based Electrodes

Bollella

2020

Nanomaterials

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Porous gold (PG) layers modified electrodes have emerged as valuable enzyme support to realize multiple enzyme-based bioelectrochemical devices like biosensors, enzymatic fuel cells (EFCs), smart drug delivery devices triggered by enzyme catalyzed reactions, etc. PG films can be synthesized by using different methods such as dealloying, electrochemical (e.g., templated electrochemical deposition, self-templated electrochemical deposition, etc.) self-assembly and sputter deposition. This review aims to summarize the recent findings about PG synthesis and electrosynthesis, its characterization and application for enzyme-based electrodes used for biosensors and enzymatic fuel cells (EFCs) development.

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Section: Introductionmentioning

confidence: 99%

Porous Gold: A New Frontier for Enzyme-Based Electrodes

Bollella

2020

Nanomaterials

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A DM1-doped porous gold nanoshell system for NIR accelerated redox-responsive release and triple modal imaging guided photothermal synergistic chemotherapy

Wang

Yang

et al. 2021

J Nanobiotechnol

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Background Although many treatments for breast cancer are available, poor tumour targeting limits the effectiveness of most approaches. Consequently, it is difficult to achieve satisfactory results with monotherapies. The lack of accurate diagnostic and monitoring methods also limit the benefits of cancer treatment. The aim of this study was to design a nanocarrier comprising porous gold nanoshells (PGNSs) co-decorated with methoxy polyethylene glycol (mPEG) and trastuzumab (Herceptin®, HER), a therapeutic monoclonal antibody that binds specifically to human epidermal receptor-2 (HER2)-overexpressing breast cancer cells. Furthermore, a derivative of the microtubule-targeting drug maytansine (DM1) was incorporated in the PGNSs. Methods Prepared PGNSs were coated with mPEG, DM1 and HER via electrostatic interactions and Au–S bonds to yield DM1-mPEG/HER-PGNSs. SK-BR-3 (high HER2 expression) and MCF-7 (low HER2) breast cancer cells were treated with DM1-mPEG/HER-PGNSs, and cytotoxicity was evaluated in terms of cell viability and apoptosis. The selective uptake of the coated PGNSs by cancer cells and subsequent intracellular accumulation were studied in vitro and in vivo using inductively coupled plasma mass spectrometry and fluorescence imaging. The multimodal imaging feasibility and synergistic chemo-photothermal therapeutic efficacy of the DM1-mPEG/HER-PGNSs were investigated in breast cancer tumour-bearing mice. The molecular mechanisms associated with the anti-tumour therapeutic use of the nanoparticles were also elucidated. Result The prepared DM1-mPEG/HER-PGNSs had a size of 78.6 nm and displayed excellent colloidal stability, photothermal conversion ability and redox-sensitive drug release. These DM1-mPEG/HER-PGNSs were taken up selectively by cancer cells in vitro and accumulated at tumour sites in vivo. Moreover, the DM1-mPEG/HER-PGNSs enhanced the performance of multimodal computed tomography (CT), photoacoustic (PA) and photothermal (PT) imaging and enabled chemo-thermal combination therapy. The therapeutic mechanism involved the induction of tumour cell apoptosis via the activation of tubulin, caspase-3 and the heat shock protein 70 pathway. M2 macrophage suppression and anti-metastatic functions were also observed. Conclusion The prepared DM1-mPEG/HER-PGNSs enabled nanodart-like tumour targeting, visibility by CT, PA and PT imaging in vivo and powerful tumour inhibition mediated by chemo-thermal combination therapy in vivo. In summary, these unique gold nanocarriers appear to have good potential as theranostic nanoagents that can serve both as a probe for enhanced multimodal imaging and as a novel targeted anti-tumour drug delivery system to achieve precision nanomedicine for cancers.

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