Control of poly(A) tail length

Eckmann, Christian R.; Rammelt, Christiane; Wahle, Elmar

doi:10.1002/wrna.56

Cited by 232 publications

(261 citation statements)

References 138 publications

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“…Another example of this type of regulators is PABPN1. In addition to its well-characterized functions in polyadenylation and poly(A) tail length control (Eckmann et al 2011), PABPN1 has recently been shown to suppress the usage of proximal PAS globally . As mentioned earlier, proximal PASs tend to lack consensus PAS sequences, such as the AAUAAA hexamer.…”

Section: Insights From Global Studies Of Apamentioning

confidence: 99%

Alternative polyadenylation: New insights from global analyses

Shi

2012

RNA

193

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Recent studies have revealed widespread mRNA alternative polyadenylation (APA) in eukaryotes and its dynamic spatial and temporal regulation. APA not only generates proteomic and functional diversity, but also plays important roles in regulating gene expression. Global deregulation of APA has been demonstrated in a variety of human diseases. Recent exciting advances in the field have been made possible in a large part by high throughput analyses using newly developed experimental tools. Here I review the recent progress in global studies of APA and the insights that have emerged from these and other studies that use more conventional methods.

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Section: Insights From Global Studies Of Apamentioning

confidence: 99%

Alternative polyadenylation: New insights from global analyses

Shi

2012

RNA

193

187

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“…In both animal and plant development, alternative 39 end cleavage sites are widely used to regulate gene expression by modulating the length of the poly(A) tails on mRNAs in the cytoplasm (Eckmann et al, 2011) to influence the stability, nuclear export, and translational efficiency of the mRNAs (Hunt, 2008).…”

Section: A Role For Mrna Maturating Complexes In the Regulation Of Dementioning

confidence: 99%

“…The poly(A) tail at the 39 untranslated region (UTR) is an essential feature of virtually all eukaryotic mRNAs that influences stability, nuclear export, and translational efficiency of the mRNA (Eckmann et al, 2011). It is synthesized after RNA polymerase II has transcribed past the cleavage and polyadenylation site and associated signal sequences.…”

mentioning

confidence: 99%

The Polyadenylation Factor Subunit CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR30: A Key Factor of Programmed Cell Death and a Regulator of Immunity in Arabidopsis

et al. 2014

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Programmed cell death (PCD) is essential for several aspects of plant life, including development and stress responses. Indeed, incompatible plant-pathogen interactions are well known to induce the hypersensitive response, a localized cell death. Mutational analyses have identified several key PCD components, and we recently identified the mips1 mutant of Arabidopsis (Arabidopsis thaliana), which is deficient for the key enzyme catalyzing the limiting step of myoinositol synthesis. One of the most striking features of mips1 is the light-dependent formation of lesions on leaves due to salicylic acid (SA)-dependent PCD, revealing roles for myoinositol or inositol derivatives in the regulation of PCD. Here, we identified a regulator of plant PCD by screening for mutants that display transcriptomic profiles opposing that of the mips1 mutant. Our screen identified the oxt6 mutant, which has been described previously as being tolerant to oxidative stress. In the oxt6 mutant, a transfer DNA is inserted in the CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR30 (CPSF30) gene, which encodes a polyadenylation factor subunit homolog. We show that CPSF30 is required for lesion formation in mips1 via SA-dependent signaling, that the prodeath function of CPSF30 is not mediated by changes in the glutathione status, and that CPSF30 activity is required for Pseudomonas syringae resistance. We also show that the oxt6 mutation suppresses cell death in other lesion-mimic mutants, including lesion-simulating disease1, mitogen-activated protein kinase4, constitutive expressor of pathogenesis-related genes5, and catalase2, suggesting that CPSF30 and, thus, the control of messenger RNA 39 end processing, through the regulation of SA production, is a key component of plant immune responses.

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“…8.1c ¢ ). A crucial aspect of cytoPAPs is that, 8 Translational Control in the Caenorhabditis elegans Germ Line contrary to nuclear PAP, the enzyme lacks a predictable RNA-binding domain (Eckmann et al 2011 ) . They associate with mRNA targets via other mRNP components and, therefore, are also referred to as noncanonical poly(A) polymerases (Wang et al 2002 ) .…”

Section: Poly(a)-tail Length Controlmentioning

confidence: 99%

Translational Control in the Caenorhabditis elegans Germ Line

Nousch

Eckmann

2012

Advances in Experimental Medicine and Biology

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Translational control is a prevalent form of gene expression regulation in the Caenorhabditis elegans germ line. Linking the amount of protein synthesis to mRNA quantity and translational accessibility in the cell cytoplasm provides unique advantages over DNA-based controls for developing germ cells. This mode of gene expression is especially exploited in germ cell fate decisions and during oogenesis, when the developing oocytes stockpile hundreds of different mRNAs required for early embryogenesis. Consequently, a dense web of RNA regulators, consisting of diverse RNA-binding proteins and RNA-modifying enzymes, control the translatability of entire mRNA expression programs. These RNA regulatory networks are tightly coupled to germ cell developmental progression and are themselves under translational control. The underlying molecular mechanisms and RNA codes embedded in the mRNA molecules are beginning to be understood. Hence, the C. elegans germ line offers fertile grounds for discovering post-transcriptional mRNA regulatory mechanisms and emerges as great model for a systems level understanding of translational control during development.

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Control of poly(A) tail length

Cited by 232 publications

References 138 publications

Alternative polyadenylation: New insights from global analyses

Alternative polyadenylation: New insights from global analyses

The Polyadenylation Factor Subunit CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR30: A Key Factor of Programmed Cell Death and a Regulator of Immunity in Arabidopsis

Translational Control in the Caenorhabditis elegans Germ Line

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