Control of Plastidial Isoprenoid Precursor Supply: Divergent 1-Deoxy- d -Xylulose 5-Phosphate Synthase (DXS) Isogenes Regulate the Allocation to Primary or Secondary Metabolism

Walter, Michael H.; Floß, Daniela S.; Paetzold, Heike; Manke, Kerstin; Vollrath, Jessica; Brandt, Wolfgang; Strack, Dieter

doi:10.1007/978-1-4614-4063-5_17

Cited by 3 publications

(1 citation statement)

References 65 publications

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“…DXS (EC 2.2.1.7) is the first entry point of the MEP pathway and a well-known rate-limiting enzyme in bacteria and plants [157,179,180]. In plants, based on sequence similarity, three different classes of DXS enzymes have been proposed: class 1 contains essential enzymes to synthesize terpenoids for photosynthesis, class 2 DXS is correlated with secondary terpenoids biosynthesis, and class 3 DXS are involved in the synthesis of isoprenoids (phytohormones) [181,182]. Manipulating the activity of DXS has been considered as an effective strategy to fine-tune the biosynthesis of terpenoids (i.e., chlorophyll, carotenoids, tocopherols, abscisic acid, or gibberellin), as demonstrated in several plants, such as Arabidopsis [183][184][185], tomato [186,187], ginkgo [188], potato [189] and carrot [190].…”

Section: Engineering Approaches For Increasing the Metabolic Flux Thrmentioning

confidence: 99%

Strategies for the production of biochemicals in bioenergy crops

Lin

Eudes

2020

Biotechnol Biofuels

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Industrial crops are grown to produce goods for manufacturing. Rather than food and feed, they supply raw materials for making biofuels, pharmaceuticals, and specialty chemicals, as well as feedstocks for fabricating fiber, biopolymer, and construction materials. Therefore, such crops offer the potential to reduce our dependency on petrochemicals that currently serve as building blocks for manufacturing the majority of our industrial and consumer products. In this review, we are providing examples of metabolites synthesized in plants that can be used as bio-based platform chemicals for partial replacement of their petroleum-derived counterparts. Plant metabolic engineering approaches aiming at increasing the content of these metabolites in biomass are presented. In particular, we emphasize on recent advances in the manipulation of the shikimate and isoprenoid biosynthetic pathways, both of which being the source of multiple valuable compounds. Implementing and optimizing engineered metabolic pathways for accumulation of coproducts in bioenergy crops may represent a valuable option for enhancing the commercial value of biomass and attaining sustainable lignocellulosic biorefineries.

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Section: Engineering Approaches For Increasing the Metabolic Flux Thrmentioning

confidence: 99%

Strategies for the production of biochemicals in bioenergy crops

Lin

Eudes

2020

Biotechnol Biofuels

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Metabolic Engineering of Isoprenoid Production: Reconstruction of Multistep Heterologous Pathways in Tractable Hosts

Maury

Asadollahi

Formenti

et al. 2012

Isoprenoid Synthesis in Plants and Microorganisms

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Analysis of a new cluster of genes involved in the synthesis of the unique volatile organic compound sodorifen ofSerratia plymuthica4Rx13

Domik¹,

Magnus²,

Piechulla³

2016

FEMS Microbiology Letters

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The rhizobacterium Serratia plymuthica 4Rx13 emits the novel and unique volatile sodorifen (C16H26), which has a polymethylated bicyclic structure. Transcriptome analysis revealed that gene SOD_c20750 (annotated as terpene cyclase) is involved in the biosynthesis of sodorifen. Here we show that this gene is located in a small cluster of four genes (SOD_c20750 - SOD_c20780), and the analysis of the knockout mutants demonstrated that SOD_c20760 (annotated as methyltransferase) and SOD_c20780 (annotated as isopentenyl pyrophosphate (IPP) isomerase) are needed for the biosynthesis of sodorifen, while a sodorifen-negative phenotype was not achieved with the SOD_c20770 (annotated as deoxy-xylulose-5-phosphate (DOXP) synthase) mutant. Altogether, the function of this new gene cluster was assigned to the biosynthesis of this structurally unusual volatile compound sodorifen.

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Control of Plastidial Isoprenoid Precursor Supply: Divergent 1-Deoxy- d -Xylulose 5-Phosphate Synthase (DXS) Isogenes Regulate the Allocation to Primary or Secondary Metabolism

Cited by 3 publications

References 65 publications

Strategies for the production of biochemicals in bioenergy crops

Strategies for the production of biochemicals in bioenergy crops

Metabolic Engineering of Isoprenoid Production: Reconstruction of Multistep Heterologous Pathways in Tractable Hosts

Analysis of a new cluster of genes involved in the synthesis of the unique volatile organic compound sodorifen ofSerratia plymuthica4Rx13

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