Abstract:In the yeast plasma membrane, phospholipids are asymmetrically distributed between the inner and outer leaflets. The outer leaflet contains predominantly phosphatidylcholine (PtdCho) and sphingolipids, whereas the inner leaflet is enriched in phosphatidylserine (PtdSer), phosphatidylethanolamine (PtdEth), phosphatidylinositol (PtdIns), and a phosphoinositide (PtdIns4,5P2). Five genes encode type 4 P‐ATPase implicated in translocating PtdSer, PtdEth and PtdCho. In particular, Dnf1 and Dnf2 catalyze inward movem… Show more
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