Control of pesticide residues by liquid chromatography‐mass spectrometry to ensure food safety

Abstract

Liquid chromatography-mass spectrometry (LC-MS) has become an invaluable technique for the control of pesticide residues to ensure food safety. After an introduction about the regulations that highlights its importance to meet the official requirements on analytical performance, the different mass spectrometers used in this field of research, as well as the LC-MS interfaces and the difficulties associated with quantitative LC-MS determination, are discussed. The ability to use practical data for quantifying pesticides together with the option of obtaining structural information to identify target and non-target parent compounds and metabolites are discussed. Special attention is paid to the impact of sample preparation and chromatography on the ionization efficiency of pesticides from food. The last section is devoted to applications from a food safety point of view. (c) 2006 Wiley Periodicals, Inc.

Multiresidue analysis of 47 pesticides in cooked wheat flour and polished rice by liquid chromatography with tandem mass spectrometry

“…More recently, liquid chromatography coupled to tandem mass spectroscopy (LC-MS/MS) was found to be far superior to the LC-MS technique for analysis of pesticide residues in a variety of food samples. It has a number of inherent properties that are advantageous for this application, including high selectivity and sensitivity, minimization of sample cleanup steps, and easy and reliable identification and quantification of pesticide residues at even very low levels (Picó et al, 2006). A number of multiresidue methods using LC-MS/MS for residue determination have been reported (Jansson et al, 2004;Ortelli et al, 2004;Cavaliere et al, 2005;Sancho et al, 2005;Hernández et al, 2006;Chen and Chen, 2007;Mertz et al, 2007;Sannino, 2007).…”

A workflow for multiclass determination of 256 pesticides in essential oils by liquid chromatography tandem mass spectrometry using evaporation and dilution approaches: Application to lavandin, lemon and cypress essential oils

“…The possibility to determine several hundred of pesticides in drinking or rinsing water by LC-MS/MS has been often reported in literature. [21][22][23][24] In this context some of us have shown the advantages in terms of data points per peaks, reproducibility, signal-to-noise ratio and number of SRM transitions, of using the sSRM algorithm available on a hybrid quadrupole linear ion trap (QLIT) mass spectrometer by comparison to the classical SRM mode.…”

“…The possibility to determine several hundred of pesticides in drinking or rinsing water by LC-MS/MS has been often reported in literature. [21][22][23][24] In this context some of us have shown the advantages in terms of data points per peaks, reproducibility, signal-to-noise ratio and number of SRM transitions, of using the sSRM algorithm available on a hybrid quadrupole linear ion trap (QLIT) mass spectrometer by comparison to the classical SRM mode.[25] For more complex matrixes such as EOs, the challenge is not only related to the number of residue to be detected and quantified but also to the sample preparation to consider for obtaining the best results in terms of limit of detection (LOD) and quantification (LOQ) and recovery rate. In fact, as highlighted in a recent review, [19] relatively few papers are dedicated to pesticides analysis in EOs and the available methods are quite limited in terms of LODs and number of simultaneously analyzed pesticides.…”

Capillary electrophoresis with immobilized quantum dot fluorescence detection for rapid determination of organophosphorus pesticides in vegetables

“…net/) and the requirements of the MRL values have been lowering down in recent years from ppm to sub-ppm levels to satisfy the increasing demand for public health protection. Various methods based on GC and HPLC have been developed to determine pesticides in food [2][3][4]. The GC procedures are suitable for the determination of volatile organochlorine pesticides.…”